anti-HtrA Serine Peptidase 1 (HTRA1) Antikörper

Zebrafish HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

1. HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.

Rhesus Monkey HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

1. Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.

2. Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR of ARMS2 to be associated with drusen.

3. As in humans, one variant within LOC387715/ARMS2 and one in HTRA1 were significantly associated with age-related macular degeneration.

Human HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

1. Heterozygous HTRA1 mutations account for 2.08% (7 of 337) of cerebral small vessel disease in Taiwan. The clinical and neuroradiological features of HTRA1-related SVD and sporadic SVD are similar.

2. proteomics study to correlate the abundance of proteins and HTRA1 levels in various cell cycle phases using label-free-quantification mass spectrometry.

3. a novel regulator involved in controlling the canonical Wnt cascade

4. The HTRA1 rs11200638 single nucleotide polymorphismis associated with neovascular age-related macular degeneration and response to ranibizumab among Malaysians.

5. The association of the SNP at the ARMS2/HTRA1 locus with subretinal/sub-RPE hemorrhage and poorer visual acuity and of SNPs at the CFH locus with drusen area may provide new insights in pathophysiological pathways underlying different stages of age-related macular degeneration.

6. description of three cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) families carrying novel null HTRA1 mutations and also the notable phenotypes among the heterozygotes

7. a structural explanation for HtrA1-defective pathologies as well as mechanistic insights into the degradation of complex extracellular fibrils such as tubulin, amyloid beta and tau that belong to the repertoire of HtrA1.

8. the integration of HtrA1 in the toolkit of mammalian cells against protein misfolding and the implications of defects in HtrA1 in proteostasis.

9. HtrA1 cleavage of thrombospondin-1 generates a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.

10. High HtrA1 expression is associated with the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuroblastoma neurite growth.

11. Nuclear downregulation of HtrA1 is associated with a better prognosis in women with high grade serous ovarian carcinoma.

12. Case Report: Novel compound heterozygous mutations in HTRA1 causing CARASIL in Chinese patient.

13. regulates odontoblastic differentiation of dental pulp cells through activation of the TGF-beta1/Smad signaling pathway

14. the aberrant expression of HTRA1 or HTRA4 may be involved in the onset of preeclampsia, and increased HTRA1 or HTRA4 expression may affect trophoblast functions.

15. HtrA1 contributes to the development of keloid lesions as matrix protease by remodelling keloid-specific ECM or cell surface molecules.

16. Studies indicate a significantly different high-temperature requirement factor A1 (HtrA1) expression in cancer and non-cancer tissue [Meta-analysis].

17. HtrA1 overexpression further leads to impaired apical processes and decreased phagocytosis, an essential function for photoreceptor survival.

18. Results suggest that HTRA1 is involved in the pathogenesis of scars through regulating activation of latent TGF-beta1 in keloid fibroblasts.

19. the CADASIL-like family disease may be caused by heterozygous HTRA1 gene mutation, which leads to autosomal dominant hereditary cerebral small vessel disease.

20. Case Report/Review: novel missense mutation in HTRA1 associated with phenotype of CARASIL.

Mouse (Murine) HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

1. Inhibition of HTRA1 in the tumor stroma impaired tumor progression by deregulating angiogenesis.

2. transfection of cells with a constitutively active rapamycin-resistant p70S6K mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.

3. Increased expressions of Tgf-beta1, p-Smad2/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.

4. In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta pathway activation.

5. HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone

6. The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD

7. the inhibitory effect of IFN-gamma on HTRA1 expression was evidenced in collagen-induced arthritis (CIA) mouse models and in human RA synovial cells.

8. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

9. Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2-induced Smad1/5/8, ERK1/2 and p38 phosphorylation in pre-osteoblasts.

10. This study offers new insights into the regulation of HTRA-1 expression via LPS/TLR-4 and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.

11. suggest a critical role for LRP1 in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor protein levels.

12. a critical role of HTRA1 in the regulation of angiogenesis via TGF-beta signaling and identified GDF6 as a novel disease gene for AMD.

13. showed that increased HTRA1 induced cardinal features of polypoidal choroidal vasculopathy, including branching networks of choroidal vessels, polypoidal lesions, severe degeneration of the elastic laminae, and tunica media of choroidal vessels

14. HtrA1 may disrupt the pericellular matrix network, resulting in alteration of chondrocyte metabolisms. This eventually leads to osteoarthritis.

15. HtrA1 has a role in promoting anoikis by attenuating activation of EGFR/AKT pathway that may contribute to its metastasis suppression capacity

16. During embryo development, HtrA1 was expressed in specific areas where signaling by Tgfbeta family proteins plays important regulatory roles

17. HtrA1 and HtrA3 show similar expression patterns and share the same inhibitory activity on TGF-beta signaling

18. HtrA1 as a protease potentially important for trophoblast differentiation/invasion and uterine decidual regression during placental development

19. bone matrix shows a high level of HtrA1 protein deposition akin to that of TGF-beta, suggesting a close functional interaction between TGF-beta and HtrA1

20. highly upregulated during mucosal mast cell differentiation

Xenopus laevis HtrA Serine Peptidase 1 (HTRA1) Interaktionspartner

1. The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.