Telefon:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antikoerper-online.de

GNAT3 Produkte

(Guanine Nucleotide Binding Protein, alpha Transducing 3, GNAT3)

Kategorien

Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase\; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Ausgewählte GNAT3 Kategorien

GNAT3 Antikörper

High quality antibodies with extensive validation data.

GNAT3 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene GNAT3 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätHuman
ApplikationFACS, IHC (p), WB
Validierungen
  • collections(3)
Kat. Nr.ABIN654441
Menge400 μL
ReaktivitätHuman
ApplikationEIA, FACS, IHC (p), WB
Validierungen
  • collections(3)
Kat. Nr.ABIN952565
Menge0.4 mL
ReaktivitätHuman
ApplikationELISA, IHC
Validierungen
  • collections(1)
Kat. Nr.ABIN335139
Menge100 μg

Empfohlene GNAT3 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätMouse
SourceInsect Cells
Validierungen
  • collections(1)
Kat. Nr.ABIN3135127
Menge1 mg
ReaktivitätHuman
SourceInsect Cells
Validierungen
  • collections(1)
Kat. Nr.ABIN3092787
Menge1 mg
ReaktivitätHuman
SourceHEK-293 Cells
Validierungen
  • collections(1)
Kat. Nr.ABIN2722098
Menge20 μg

Neueste Publikationen zu unseren GNAT3 Produkten

Jang, Kokrashvili, Theodorakis, Carlson, Kim, Zhou, Kim, Xu, Chan, Juhaszova, Bernier, Mosinger, Margolskee, Egan: "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 38, pp. 15069-74, 2007 (PubMed).

Ma, Sheng, Zhang, Zhang, He, Huang, Chen, Sultz, Adegboyega, Zhang, Xie: "Hedgehog signaling is activated in subsets of esophageal cancers." in: International journal of cancer. Journal international du cancer, Vol. 118, Issue 1, pp. 139-48, 2005 (PubMed).

Synonyme und alternative Namen zu GNAT3

G protein subunit alpha transducin 3 (GNAT3), guanine nucleotide binding protein, alpha transducing 3 (Gnat3), G protein subunit alpha transducin 3 (Gnat3), GDCA, Ggust, gnat-3, Gtn

Gen-IDs für verschiedene Spezies

GENE ID SPEZIES
427851 Gallus gallus
472426 Pan troglodytes
100012963 Monodelphis domestica
100387752 Callithrix jacchus
100431387 Pongo abelii
100600721 Nomascus leucogenys
346562 Homo sapiens
491406 Canis lupus familiaris
242851 Mus musculus
286924 Rattus norvegicus
100511528 Sus scrofa
516262 Bos taurus

Bezeichner auf Proteinebene für GNAT3

  • guanine nucleotide-binding protein G(t) subunit alpha-3
  • gustducin
  • guanine nucleotide binding protein, alpha transducing 3
  • guanine nucleotide-binding protein G(t) subunit alpha-3-like
  • gustducin alpha-3 chain
  • alpha-gustducin
Sie sind hier:
help Kundenservice