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Collectively, these data indicate that Syn4 suppresses the cellular proliferation during neurogenesis and is crucial for the formation of caudal primary axons during zebrafish embryogenesis.
We show here that sdc2 (zeige SDC2 Proteine),sdc3 (zeige SDC3 Proteine) and sdc4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
cell adhesion properties of syndecan-4 are consistent across the vertebrate spectrum and reflect an early acquisition of specialization after syndecan (zeige SDC1 Proteine) gene duplication events at the invertebrate/early chordate boundary
Dynamic changes in syndecan-4- and glypican-1 (zeige GPC1 Proteine)-positive satellite cells indicate that they are differentially expressed during myogenesis.
The cytoplasmic domain of syndecan-4 is required for cell migration and RhoA (zeige RHOA Proteine) activation in skeletal muscle satellite cells.
results suggest that syndecan-4 and its side chains play important roles in regulating FAK (zeige PTK2 Proteine) activity, and PKCalpha (zeige PKCa Proteine) and beta1-integrin cell membrane localization, but not cell apoptosis and vinculin (zeige VCL Proteine)-containing focal adhesion formation in satellite cells
These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 (zeige GPC1 Proteine) and syndecan-4 during satellite cell proliferation and differentiation, and Pax7 (zeige PAX7 Proteine) expression is influenced by glypican-1 (zeige GPC1 Proteine).
syndecan-1 (zeige SDC1 Proteine), syndecan-4, or glypican-1 (zeige GPC1 Proteine) differentially affect the processes of turkey muscle cell proliferation and differentiation, and can regulate these developmental stages in an FGF2 (zeige FGF2 Proteine)-independent manner
studies are required to show if syndecan-4 concentrations can be marker for prognosis assessment or disease progression
Data provide evidence that SDC4 plays important roles in normal physiology of intervertebral disc and cartilage through controlling growth factor signaling and matrix homeostasis. However, several studies to date clearly show that in diseased joints, SDC4 and inflammatory cytokines IL-1beta (zeige IL1B Proteine) and TNF-alpha (zeige TNF Proteine) form a positive feedback loop, wherein they control each other's expression and/or activity. [review]
This study demonstrates that the shedding of synd4 from Endothelial progenitor cells (EPCs) plays a key role in advanced glycation end products-mediated dysfunction of EPC (zeige TCF21 Proteine) migration and homing.
the Ser179Glu mutant of SDC-4 binds strongly Tiam1 (zeige TIAM1 Proteine), a Rac1-GEF (zeige SLC2A4RG Proteine) reducing Rac1-GTP (zeige AK3 Proteine) by 3-fold in MCF-7 breast adenocarcinoma cells.
Syndecan 4 is the biomarker independently distinguishing Heart Failure with preserved ejection fraction and Heart Failure with reduced ejection fraction.
The upregulation of syndecan-4 in the eutopic endometrium of endometriosis patients may facilitate the pathogenetic process by promoting invasive cell growth via Rac1, MMP3 (zeige MMP3 Proteine), and ATF-2 (zeige ATF2 Proteine).
Sdc4 has been identified as a mycobacterial attachment receptor on alveolar epithelial cells.
Study has demonstrated that SDC-4 expression was increased in sera and skin of atopic dermatitis (AD) patients, suggesting that SDC-4 may contribute to the development of AD.
the present study demonstrated that synd4 was involved in the chemotactic migration of ECs in vitro and in vivo.
results suggest that SDC4 alleles affect lipid profile in elderly subjects and may in part mediate the link between LDL-C and longevity.
Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4.
Syndecan-4 is essential for the compensated hypertrophy and the maintenance of cardiac function during the process of heart failure following pressure overload.
Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.
SDC4 thus controls flow-induced lymphatic endothelial cell polarization via regulation of VANGL2 (zeige VANGL2 Proteine) expression.
loss of N-sulfation leads to the disruption of the pattern of distribution of Sdc-4 within the glomeruli of Ndst1 (zeige NDST1 Proteine)-/- mutants
Synd4 shedding from vascular endothelial cells played an important role in the diabetes-related impairment of angiogenesis.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (zeige NFE2L2 Proteine)-mediated control of SLPI (zeige SLPI Proteine) and syndecan 4.
Syndecan-4 mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR (zeige EGFR Proteine).
TGF-beta1 (zeige TGFB1 Proteine) modulates the expression of syndecan-4 in cultured vascular endothelial cells in a biphasic manner.
Findings suggest that syndecan-4 may be involved in acquisition of resistance to detachment-induced cell death (anoikis resistance) in endothelial cells, thus contributing to cell transformation.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22.
, ryudocan core protein
, syndecan 4 like
, heparan sulfate proteoglycan
, syndecan 4 (amphiglycan, ryudocan)
, ryudocan amphiglycan
, syndecan proteoglycan 4
, Ryudocan/syndecan 4