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anti-Human GPC5 Antikörper:
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Human Monoclonal GPC5 Primary Antibody für CyTOF, FACS - ABIN4899914
Williamson, Selfe, Gordon, Lu, Pritchard-Jones, Murai, Jones, Workman, Shipley: Role for amplification and expression of glypican-5 in rhabdomyosarcoma. in Cancer research 2007
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Hotair promoted Gastric Cancer development by promoting GCP5 expression via sponging miR-217.
Our results showed that GPC5 was lowly expressed in PCa cell lines.
Taken together, our results suggest GPC5 as a tumor suppressor in PDAC and its expression is possibly regulated by miR-4295. Our study indicates that the miR-4295/GPC5 axis may play an important role in the pathogenesis of PADC and has potential applications for the development of PDAC therapy.
Suggest that GPC5 is able to suppress the lung adenocarcinoma metastasis by competitively binding to Wnt3a and inactivating the Wnt/beta-catenin signaling pathway.
GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits tumor growth by suppressing Wnt/beta-catenin signaling in lung adenocarcinoma.
GPC5 protein expression showed a close correlation with the tumorigenesis and tumor progression of prostate cancer, and that might be applied as a novel biomarker for the prediction of diagnosis and prognosis of prostate cancer.
These results suggest that miR-297 acted as an oncogenic miRNA, partly by targeting GPC5, adenocarcinoma of the lung.
Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.
miR-709 may positively regulate invasion and metastasis of hepatocellular carcinoma through targeting GPC5.
gene variants in IRF5, IRF8 and GPC5 were not associated with risk of relapse or disease progression in multiple sclerosis
GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma.
Variants in the 50-upstream region of GPC5 confer risk of lung cancer in never smokers
These results indicate that GPC5 polymorphisms would be useful genetic indicators for Inflammatory demyelinating diseasess, including neuromyelitis optica and multiple sclerosis .
The IL7R, TNFRSF1A, and GPC5 polymorphisms tended to be associated with having a second event of Multiple sclerosis within a year.
Shh binds to HSPG co-receptors containing a glypican 5 core and 2-O-sulfo-iduronic acid to promote neural precursor proliferation.
Data suggest that glypican-5 (GPC5) is a metastasis suppressor gene in non-small cell lung cancer (NSCLC) and may be a potential biomarker that predicts NSCLC metastasis.
GPC5 is a gene required for normal neural tube development.
findings suggested that SNP rs2352028 in GPC5 might confer a slight risk to lung cancer/adenocarcinoma
GPC5 stimulates Hh signaling by facilitating/stabilizing the interaction between Hh and Ptc1.
GPC5 is a novel genetic locus protective against sudden cardiac arrest
The findings elucidate the pivotal role of GPC5, identified as a susceptible gene in the genome-wide association study, in hyperglycemia-induced glomerulopathy.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
, glypican proteoglycan 5