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Human Glypican 3 ELISA Kit für Sandwich ELISA - ABIN414787
Tangkijvanich, Chanmee, Komtong, Mahachai, Wisedopas, Pothacharoen, Kongtawelert: Diagnostic role of serum glypican-3 in differentiating hepatocellular carcinoma from non-malignant chronic liver disease and other liver cancers. in Journal of gastroenterology and hepatology 2010
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Human Glypican 3 ELISA Kit für Sandwich ELISA - ABIN365731
Yao, Yao, Bian, Wu, Yan, Yu, Qiu, Yang, Zhang, Sai, Chen: Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma. in Hepatobiliary & pancreatic diseases international : HBPD INT 2013
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The diagnostic sensitivity for hepatocellular carcinoma increased to 72.8% (206 of the 283) when glypican 3 was combined with alpha-fetoprotein (zeige AFP ELISA Kits).
The lncRNA glypican 3 antisense transcript 1 (GPC3-AS1 (zeige PTGDR ELISA Kits)) has been reported to be a potential biomarker for hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) screening. We observed a significant upregulation of GPC3-AS1 (zeige PTGDR ELISA Kits) in HCC (zeige FAM126A ELISA Kits). Increased expression of GPC3-AS1 (zeige PTGDR ELISA Kits) was associated with alpha-fetoprotein (zeige AFP ELISA Kits), tumor size, microvascular invasion, encapsulation, Barcelona Clinic Liver Cancer stage, and worse prognosis of HCC (zeige FAM126A ELISA Kits) patients.
study provides the first evidence that GPC3 can modulate the PCSK9 (zeige PCSK9 ELISA Kits) extracellular activity as a competitive binding partner to the LDLR (zeige LDLR ELISA Kits) in HepG2 cells.
By subsequent Sanger sequencing of genomic DNA we could map the chromosomal break points to define a deletion size of 43,617 bp including exons 5 and 6 of the GPC3 gene.
This is the first study in which the optimal HLA-A*0201 GPC3 epitopes were screened from a large number of candidates predicted by three software. The optimized HLA-A*0201 GPC3 peptides will provide new epitope candidates for hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) immunotherapy.
GPC3 and KRT19 (zeige KRT19 ELISA Kits) overexpression are associated with carcinogenesis, progression, and poor prognosis in patients with PDAC and a valuable biomarker for diagnosis of PDAC.
The clinical implication of GPC3 detection and targeting in the management of patients with hepatocellular carcinoma. Review.
Glypican 3 expression showed a significant difference between endometrioid endometrial carcinoma and serous endometrial carcinoma, and it was significantly correlated with tumor grade, stage and myometrial invasion
Data show that notum (zeige NOTUM ELISA Kits) and glypican-1 (zeige GPC1 ELISA Kits) and glypican-3 gene expression during colorectal cancer (CRC (zeige CALR ELISA Kits)) development and present evidence to suggest them as potential new biomarkers of CRC (zeige CALR ELISA Kits) pathogenesis.
GPC3 expression was measured in hepatocellular carcinoma at different stages and correlated with prognosis. CK19 (zeige KRT19 ELISA Kits)+/GPC3+ HCC (zeige FAM126A ELISA Kits) has the highest risk of intrahepatic metastasis, microvascular invasion, regional lymph node involvement, and distant metastasis.
Data show that notum (zeige NOTUM ELISA Kits) and glypican-1 (zeige GPC1 ELISA Kits) and glypican-3 gene expression during colorectal cancer (CRC (zeige SCRIB ELISA Kits)) development and present evidence to suggest them as potential new biomarkers of CRC (zeige SCRIB ELISA Kits) pathogenesis.
Coupling of pGPC3 to liposomes was essential for effective priming of GPC3-specific CTLs.
The expression of GPC-3 was altered by DEN treatment.
Data suggest that GPC3 down-regulates hepatocyte proliferation by binding to hedgehog (zeige SHH ELISA Kits) (HH) and down-regulating the HH signaling pathway and binding with CD81 (zeige CD81 ELISA Kits), thus making it unavailable to bind to Hhex (zeige HHEX ELISA Kits) and causing its nuclear translocation.
Finding represents a rare four layer genomic overlap consisting of growth associated quantitative trait locus (QTL), body mass associated Gpc3 gene, highly conserved miRNA gene and mature miRNA seed SNP identified in the lean mouse.
Hepatocyte overexpression of GPC3 suppresses hepatocyte proliferation and liver regeneration and alters gene expression profiles.
glypican-3 is involved in the recruitment of M2-polarized tumor-associated macrophages in hepatocellular carcinoma
GPC3 inhibits the PI3K/Akt (zeige AKT1 ELISA Kits) anti-apoptotic pathway while it stimulates the p38MAPK (zeige MAPK14 ELISA Kits) stress-activated one in murine mammary adenocarcinoma LM3 cells
Gpc3 function in development of Simpson-Golabi-Behmel syndrome is IGF-independent
GPC3 knockout mice exhibit alterations in the Wnt (zeige WNT2 ELISA Kits) signaling pathway, which is also associated with the regulation of cell proliferation
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
, glypican proteoglycan 3
, heparan sulphate proteoglycan
, intestinal protein OCI-5
, secreted glypican-3
, defective in Simpson-Golabi-Behmel overgrowth syndrome
, proteoglycan GPC3
, Intestinal protein OCI-5