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Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 (zeige EWSR1 Proteine) KO mice
LGN (zeige GPSM2 Proteine) and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing.
stimulation of GPR17 (zeige GPR17 Proteine) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (zeige MBP Proteine) expression levels mainly by triggering the Galphai/o signaling pathway.
Gnai1 missense mutation is responsible of hyperpigmentation in mouse model.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure.
leucine can directly facilitate insulin (zeige INS Proteine) signaling through a Galphai protein-dependent intracellular signaling pathway
Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.
Mice with mutations of Gnai1 or Gnai2 (zeige GNAI2 Proteine) have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 (zeige GNAI3 Proteine) and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions.
GIV is a bifunctional modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galphas (zeige GNAS Proteine) using the same motif that allows it to serve as a guanine-nucleotide exchange factor (zeige RASGRF1 Proteine) for Galphai
The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb (zeige GTPBP4 Proteine) are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb (zeige GTPBP4 Proteine).
GTP (zeige AK3 Proteine) analogs leads to a rigid and closed arrangement of the Galphai1, whereas the apo (zeige C9orf3 Proteine) and GDP-bound forms are considerably more open and dynamic.
The results show ZIP9 (zeige SLC39A9 Proteine) is a specific Gi coupled-membrane AR mediating testosterone-induced MAP kinase (zeige MAPK1 Proteine) and zinc signaling in PC3 (zeige PCSK1 Proteine)-ZIP9 (zeige SLC39A9 Proteine) cells.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (zeige GNAI2 Proteine), and Galphai3 (zeige GNAI3 Proteine), with no evidence for functional coupling to Galphagust.
testosterone rapidly increased whole-cell HCAEC SKCa and BKCa (zeige KCNMA1 Proteine) currents via a surface androgen receptor (zeige AR Proteine), Gi/o protein, and protein kinase A
These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.
CGRP (zeige S100A12 Proteine) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (zeige GNAS Proteine), Galphai, and Galphaq (zeige GNAQ Proteine)/11 pathways.
biochemical and computational data indicate that the interactions between alpha5, alpha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (zeige RND2 Proteine) (or GDP rebinding).
Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin (zeige HBG1 Proteine) expression, predominantly through the Gialpha/JNK (zeige MAPK8 Proteine)/Jun (zeige JUN Proteine) pathway.
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 1
, guanine nucleotide-binding protein G(i) subunit alpha-1
, Gi1 protein alpha-subunit
, alpha-subunit of G-protein, type G-alpha-i-1
, guanine nucleotide-binding protein G(i), alpha-1 subunit
, Gi1 protein alpha subunit
, Gi-alpha-1 protein
, guanine nucleotide binding protein (G protein), alpha inhibiting 1
, Galpha i1a