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Orthopedic surgery modulates the expression of neuropeptide Y and BDNF (zeige BDNF Proteine) at the spinal and hippocampal levels.
salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus
NPY deficient mice had significantly impaired Hematopoietic stem/progenitor cell (HSPC (zeige PSMA7 Proteine)) mobilization due to increased expression of HSPC (zeige PSMA7 Proteine) maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9 (zeige MMP9 Proteine)) activity in bone marrow.
These results identify SK3 (zeige KCNN3 Proteine) as a key intrinsic mediator that coordinates nutritional status with AgRP (zeige AGRP Proteine)/NPY neural activities and animals' feeding behavior and energy metabolism.
The vasoconstrictive mechanism has been identified as neuropeptide Y acting on Y1 receptors.
Findings suggest that neuropeptide Y is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
arcuate nucleus NPY neuropathway to the paraventricular nucleus and dorsomedial hypothalamus is pivotal in obesity-induced elevations in sympathetic nerve activity.
NPY promotes airway hyperresponsiveness through the induction of Rho kinase activity and phosphorylation of myosin light chain, which induces airway smooth muscle contraction.
stress alters CA1 (zeige CA1 Proteine) circuit function through the impairment of endogenous NPY release, potentially contributing to heightened anxiety
Npy expression is decreased in the cingulate cortex following chronic unpredictable stress.
genetic variation in NPY and NPY2R (zeige NPY2R Proteine) is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
Genetic risk score (GRSNPY) analysis found twelve significant (P<0.05) serum NPY concentration related SNPs among alpha7 nicotinic acetylcholine receptor gene CHRNA7 (zeige CHRNA7 Proteine), insulin receptor (zeige INSR Proteine) gene INSR (zeige INSR Proteine), leptin receptor (zeige LEPR Proteine) gene LEPR (zeige LEPR Proteine), glucocorticoid receptor (GR (zeige NR3C1 Proteine)) gene NR3C1 (zeige NR3C1 Proteine), and NPY gene. However, after permutation test of gene score the predictive value of GRSNPY remained non-significant (P=0.078). CONCLUSIONS: Serum NPY level ...
In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia.
Both structural (+1128T/C) and promoter polymorphisms (-399 T/C) of Neuropeptide Y are strongly associated with type-II diabetes susceptibility in Gujarat population which at least in part, may result in higher levels of Neuropeptide Y thereby suggesting its crucial role in type-II diabetes susceptibility.
Hypermethylation of WIF1 (WNT inhibitory factor 1 (zeige WIF1 Proteine)) and NPY (neuropeptide Y) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage.
Our results provided clinical evidences for NPY participating in the bone healing process in a nonhypothalamic manner, most probably by directly promoting osteogenesis of mesenchymal stem cells.
In conclusion, the obtained results demonstrate the probable role of NPY SNPs in susceptibility to multiple sclerosis within the Iranian population.
Neuropeptide Y is the best dipeptidyl peptidase 4 (DPP4 (zeige DPP4 Proteine))-substrate in blood, being truncated by soluble and membrane DPP4 (zeige DPP4 Proteine), respectively. The decline of soluble DPP4 (zeige DPP4 Proteine) in acute depression could be reversed upon anti-depressive treatment.
study implicates NPY as a potential target in antihypertensive therapies for preeclampsia patients
NPY is efficiently cleaved by FAP indicating a potential function for FAP in neuropeptide regulation within liver and cancer biology.
NPY acts as an orexigenic factor in the zebrafish.
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.(
Developmental expression of zYb and zYc receptors suggests a role for neuropeptide Y (NPY) in organogenesis.
In this study described the the lateral line presence of NPY-like immunoreactivity (IR) in of the Antarctic nototheniod fish. Differences in size and cellular composition between the two neuromasts were presen NPY immunoreactivity.
Neuropeptide Y mRNA content decreased 6 h after a meal, but increased to prefeeding levels by 24 h.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (zeige LEP Proteine)-NPY and insulin (zeige INS Proteine) signaling pathways.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin (zeige LEP Proteine) and hypothalamic neuropeptide Y (NPY) release.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin (zeige LEP Proteine), and IGF-1 (zeige IGF1 Proteine) genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
The NPY SNP (NPY1) was associated with the prevalence of the animal being in calf 100 d after calving and 305-d milk yield in the first lactation.
NPY tended to increase serum growth hormone (zeige GH1 Proteine), which appeared to be a consequence of increased pulse amplitude. Infusion of NPY also increased CSF (zeige CSF2 Proteine) growth hormone-releasing hormone (zeige GHRH Proteine).
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin (zeige GAL Proteine), somatostatin (zeige SST Proteine), NPY, and VIP (zeige Vip Proteine).
Results show that the PP-fold is not important for recognition of peptide YY or neuropeptide Y at Y receptors.
NPY has a positive inotropic effect in isolated rat cardiac myocytes, which involves increase in Ca2 (zeige CA2 Proteine)+ release after activation of Y1 NPY receptor
High dietary copper appears to increase feed intake and promote weight gain by enhancing NPY concentration and NPY mRNA expression level in the hypothalamus of pigs.
Neuropeptide Y was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of neurogenic pulmonary edema
The present investigation provides results of increased vasocontractile effect of NOR and decreased enhancing effect of NPY on NOR vasoconstriction in the rabbit facial artery after carotid occlusion that is related to altered endothelium function
A 2-day fast increased NPY gene expression in the supraoptic nucleus and paraventricular nucleus.
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
, prepro-neuropeptide Y
, neuropeptide Yb
, pre-pro hormone
, preproneuropeptide Y, preproNPY
, neuropeptide Y
, neuropeptide Ya
, pro-neuropeptide Y preproprotein
, Pro-neuropeptide Y