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phosphorylated MRLC temporally controls its own accumulation, but not that of actin, in cultured mammalian cells.
The study data show that manipulation of the activation sites (Thr18/Ser19) significantly alters myosin II function in a number of these assays while manipulation of the putative inhibitory sites (Ser1/Ser2/Thr9) does not.
These results suggest that 2P-MRLC has a role different from that of 1P-MRLC at the midzone, and is not a subunit of myosin II.
These results suggest that EGCG inhibits the cell growth by reducing the MRLC phosphorylation and this effect is mediated by the 67LR.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
The activity of nonmuscle myosin II (see MYH9\; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001
, myosin RLC-B
, myosin light chain, regulatory B
, myosin regulatory light chain 12B
, myosin regulatory light chain 2-B, smooth muscle isoform
, myosin regulatory light chain 20 kDa
, myosin regulatory light chain MRLC2
, myosin regulatory light chain-B
, myosin regulatory light chain 2
, myosin regulatory light chain MRCL2
, myosin light chain 2
, myosin, light chain 12B, regulatory
, myosin regulatory light polypeptide 9-like
, myosin light chain 12B L homeolog
, myosin regulatory light chain