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Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population.
no indications were found for an association between the MBX gene and microphthalmia with congenital cataract in humans
The crystal structure of mouse ATX in complex with an anti-ATX aptamer.
Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 and AgRP (agouti-related peptide) is important in appetite regulation leading to leanness.
Dmbx1, a novel evolutionarily conserved paired-like homeobox gene is expressed in the brain of mouse embryos. Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4.
provides a useful molecular marker for early mouse midbrain development and may play a critical role in brain development
results suggest that Otx3 is a novel member of the Otx family and may be involved in the development of the central nervous system
Dmbx1 gene is expressed in the developing mouse diencephalon, midbrain and hindbrain, and has dynamic expression during forelimb and hindlimb development
Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum
Dmbx1 is expressed only in the developing central nervous system and in particular during early determination and successive differentiation of the midbrain and caudal diencephalon
Results demonstrate that Dmbx1 is required for postnatal survival, growth, and brain development.
Otx3/Dmbx1 represses Otx2-mediated transcription in the developing brain
Dmbx1 is essential for various actions of agouti-related protein and plays a role in normal regulation of energy homeostasis and behavior
Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression.
Data suggest that both zebrafish dmbx1a and dmbx1b genes are retained in the fish genome due to their requirement during midbrain and retinal neurogenesis, although their function is partially diverged.
mbx homeobox gene is required for the development of the eyes and tectum.
revealed a pattern of partial spatiotemporal expression divergence between the mbx paralogs that correlates with sequence divergence in noncoding regulatory domains
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene.
diencephalon/mesencephalon homeobox protein 1
, homeoprotein MBX
, orthodenticle homolog 3
, paired-like homeobox protein DMBX1
, paired-type homeobox Atx
, diencephalon/mesencephalon homeobox 1
, diencephalon/mesencephalon-expressed brain homeobox 1
, diencephalon/mesencephalon-expressed brain homeobox gene 1 protein
, homeobox gene Atx
, orthodenticle 3
, diencephalon/mesencephalon homeobox protein 1-B
, paired-type homeobox transcription factor Mbx2
, diencephalon/mesencephalon homeobox protein 1-A
, diencephalon/mesencephalon-expressed brain homeobox gene 1
, homeoprotein Mbx
, paired homeobox protein 1