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Acute loss of IRS1/IRS2 or inhibition of IR/IGF (zeige INSR Proteine)1R in KRAS-mutant human NSCLC cells decreases the (zeige IRS2 Proteine) uptake and lowers the intracellular levels of amino acids, while enhancing basal autophagy and sensitivity to autophagy and proteasome i (zeige TP53 Proteine)nhibitors.
S6K1 (zeige RPS6KB1 Proteine)-dependent IRS (zeige IARS Proteine)-1pSer suppresses insulin (zeige INS Proteine) signaling leading to insulin (zeige INS Proteine) resistance, which is frequently observed in AD brains. Notably, miR (zeige MLXIP Proteine)-200b/c transfection of SH-SY5Y cells reduced the levels of IRS (zeige IARS Proteine)-1pSer. This finding indicates that miR (zeige MLXIP Proteine)-200b/c has the potential to alleviate insulin (zeige INS Proteine) resistance via modulation of S6K1 (zeige RPS6KB1 Proteine)
Together, miR (zeige MLXIP Proteine)-145 mimics suppress cell proliferation by targeting and inhibiting IRS1 expression to inhibit MAPK/ERK (zeige MAPK1 Proteine) signaling pathways.
Data suggest that Y537S/D538G ESR1 (zeige ESR1 Proteine) mutant breast cancer cell lines exhibit enhanced proliferation in response to IGF1 (zeige IGF1 Proteine)/IGF1R (zeige IGF1R Proteine) signaling; mechanism involves IRS1; here, knockdown of IRS1 attenuates enhanced IGF1 (zeige IGF1 Proteine)/IGF1R (zeige IGF1R Proteine) signaling response in ESR1 (zeige ESR1 Proteine) mutant cells. (ESR1 (zeige ESR1 Proteine) = estrogen receptor 1 (zeige ESR1 Proteine); IGF1 (zeige IGF1 Proteine) = insulin like growth factor 1 (zeige IGF1 Proteine); IGF1R (zeige IGF1R Proteine) = IGF1 (zeige IGF1 Proteine) receptor; IRS1 = insulin receptor substrate 1)
The effect of PF may be associated with its role in inhibiting de novo lipid synthesis and in regulating the ROCK/IRS (zeige IARS Proteine)/Akt (zeige AKT1 Proteine) signalling pathways.
Gene expression for insulin receptor substrate 1 (IRS-1), protein kinase B (Akt-2) and glucose transporter 4 (GLUT-4 (zeige SLC2A4 Proteine)) genes were evaluated by real time PCR.
Reduced insulin receptor substrate-1 (IRS-1) staining in lung adenocarcinoma tissue microarray displayed a significant survival disadvantage, especially within the Kirsten rat sarcoma viral oncogene (zeige RAB1A Proteine) homolog (KRAS) mutant subgroup.
This study examined the normal regional brain expression of IRS-1 and found a significant correlation with the volumetric associated with regional atrophy in Alzheimer's disease.
Data show that MIR126 induces autophagic flux in malignant mesothelioma (MM) cells by downregulating insulin receptor substrate-1 (IRS1) and disrupting the IRS1 signaling pathway.
IRS1/beta-Catenin (zeige CTNNB1 Proteine) Axis Is Activated and Induces MYC (zeige MYC Proteine) Expression in Acute Lymphoblastic Leukemia Cells
'selective insulin (zeige INS Proteine) resistance' is caused by the differential expression of Irs1 and Irs2 (zeige IRS2 Proteine) in different zones of the liver
Lung-specific dual ablation of insulin receptor (zeige INSR Proteine) substrates 1/2 (succumb to tumor burdenIrs1/Irs2 (zeige IRS2 Proteine)) strongly suppresses tumor initiation and dramatically extends the survival of a mouse model of lung cancer with Kras activation and p53 (zeige TP53 Proteine) loss. Mice with Irs1/Irs2 loss eventually.
Noise exposure led to enhanced JNK (zeige MAPK8 Proteine) phosphorylation and IRS1 serine phosphorylation as well as reduced Akt (zeige AKT1 Proteine) phosphorylation in skeletal muscles in response to exogenous insulin (zeige INS Proteine) stimulation.
The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 (zeige SIRT1 Proteine) activation, which in turn increases IRS1 phosphorylation and GLUT4 (zeige SLC2A4 Proteine) translocation in myotubes.
Results show that lack of IRS1 prevents beta-cell apoptosis induced by ER stress, and promotes XBP-1 (zeige XBP1 Proteine) instability secondary to proteasomal degradation.
Using two long-lived IIS models, namely Drosophila lacking three insulin (zeige INS Proteine)-like peptides (dilp2 (zeige FLNA Proteine)-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms
findings suggest that up-regulation of miR (zeige MLXIP Proteine)-222 followed by reduction in IRS-1 expression may be a viable mechanism of insulin (zeige INS Proteine) resistance in the liver
These results demonstrate the cooperative interaction between RPTPbeta (zeige PTPRZ1 Proteine) and the IGF-I receptor (zeige IGF1R Proteine) leading to a coordinated series of signaling events that are required for osteoblast differentiation. Our findings emphasize the important role IRS-1 plays in modulating these signaling events and confirm its essential role in facilitating osteoblast differentiation
EGCG significantly ameliorated insulin (zeige INS Proteine) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (zeige BDNF Proteine)) signaling pathways.
Pit1 (zeige POU1F1 Proteine) deletion inhibited USP7 (zeige USP7 Proteine)/IRS1 dissociation upon insulin (zeige INS Proteine) stimulation.
IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (zeige FTO Proteine) genes regulates body weight in rabbits.
miR (zeige MYLIP Proteine)-146a-5p targets porcine insulin receptor (zeige INSR Proteine) and could inhibit its protein expression.
TBC1D4 (zeige TBC1D4 Proteine), insulin receptor (zeige INSR Proteine) and GLUT4 (zeige SLC2A4 Proteine) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.
Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (zeige PAX6 Proteine) and a decreased cell proliferation.
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
, insulin receptor substrate 1
, insulin receptor substrate 1-A