Insulin Receptor Substrate 1 Proteine (IRS1)

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Synonyme:
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu
alle Proteine anzeigen Gen GeneID UniProt
IRS1 3667 P35568
IRS1 16367 P35569
Ratte IRS1 IRS1 25467 P35570

Insulin Receptor Substrate 1 Proteine (IRS1) nach Spezies

Weitere Proteine zu Insulin Receptor Substrate 1 Interaktionspartnern

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. miR (zeige MYLIP Proteine)-146a-5p targets porcine insulin receptor (zeige INSR Proteine) and could inhibit its protein expression.

  2. TBC1D4 (zeige TBC1D4 Proteine), insulin receptor (zeige INSR Proteine) and GLUT4 (zeige SLC2A4 Proteine) showed altered expression in some tissues in pre-diabetic pigs.

  3. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.

  2. Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.

  3. G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.

  4. The results suggest that high glucose compromises the insulin (zeige INS Proteine) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.

  5. The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.

  6. IRS-1 and IRS-2 (zeige IRS2 Proteine) signaling interaction with the microtubule cytoskeleton and its response to AKT (zeige AKT1 Proteine) determines the response to microtubule disruption in breast carcinoma cells

  7. Findings suggest that the induction of microRNA miR (zeige MLXIP Proteine)-1271 by saturated fatty acid palmitate promotes the development of insulin (zeige INS Proteine) resistance by targeting insulin receptor (INSR (zeige INSR Proteine)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.

  8. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (zeige INS Proteine), IRS2 (zeige IRS2 Proteine), PPAR-G (zeige ARF6 Proteine) and CAPN10 (zeige CAPN10 Proteine) failed to show any association with PCOS in our studied population.

  9. Consistent with these observations, LPIN1 (zeige LPIN1 Proteine) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (zeige LPIN1 Proteine) may be a promising drug target for anticancer therapy

  10. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (zeige IRS2 Proteine) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (zeige INSR Proteine) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (zeige MLXIP Proteine)-342

  2. Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.

  3. In conclusion, we have identified that ARL15 acts as an insulin (zeige INS Proteine)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (zeige PDPK1 Proteine)/AKT (zeige AKT1 Proteine) insulin (zeige INS Proteine) pathway by interacting with its GAP ASAP2 (zeige ASAP2 Proteine) and activating PDPK1 (zeige PDPK1 Proteine). This research may provide new insights into GTPase (zeige RACGAP1 Proteine)-mediated insulin (zeige INS Proteine) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (zeige INS Proteine) sensitizati

  4. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (zeige INS Proteine) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation

  5. Decreased miR (zeige MLXIP Proteine)-33 levels can up-regulate IRS-2 (zeige IRS2 Proteine) expression, which appears to compensate for the defects of the insulin (zeige INS Proteine) signaling pathway in Irs-1 deficient mice.

  6. Acute knockdown of Insr (zeige INSR Proteine) or both Irs1 and Irs2 (zeige IRS2 Proteine) in adipocytes increased Adipoq (zeige ADIPOQ Proteine) mRNA expression but reduced adiponectin (zeige ADIPOQ Proteine) secretion.

  7. Concentration of SOCS-3 (zeige SOCS3 Proteine) protein and coimmunoprecipitation of SOCS-3 (zeige SOCS3 Proteine) protein with both the IR-beta subunit (zeige POLG Proteine) as well as IRS-1 was found to be decreased by 4-HIL

  8. Authors propose that insulin (zeige INS Proteine)/IGF-1 (zeige IGF1 Proteine) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (zeige PROP1 Proteine) longevity phenotype.

  9. within the hepatic compartment, mTORC1 --> S6K (zeige RPS6KB1 Proteine) signaling regulates Akt (zeige AKT1 Proteine) largely through IRS (zeige IARS Proteine)-independent means with little effect upon physiologic insulin (zeige INS Proteine) sensitivity.

  10. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (zeige FAM126A Proteine) development and progression.

Rabbit Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (zeige FTO Proteine) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (zeige PAX6 Proteine) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) Protein Überblick

Protein Überblick

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2)
  • insulin receptor substrate 1 (IRS1)
  • insulin receptor substrate 1 (Irs1)
  • insulin receptor substrate 1 (irs1)
  • G972R Protein
  • HIRS-1 Protein
  • irs-1 Protein
  • IRS1 Protein
  • irs1-a Protein
  • IRS1IRM Protein
  • irsu Protein

Bezeichner auf Proteinebene für IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

GENE ID SPEZIES
394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
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