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Human Polyclonal vcp Primary Antibody für ICC, IF - ABIN151102
Clemen, Tangavelou, Strucksberg, Just, Gaertner, Regus-Leidig, Stumpf, Reimann, Coras, Morgan, Fernandez, Hofmann, Müller, Schoser, Hanisch, Rottbauer, Blümcke, von Hörsten, Eichinger, Schröder: Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases. in Brain : a journal of neurology 2010
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Chicken Monoclonal vcp Primary Antibody für IF, WB - ABIN968777
Egerton, Ashe, Chen, Druker, Burgess, Samelson: VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. in The EMBO journal 1992
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Chicken Monoclonal vcp Primary Antibody für IF, WB - ABIN968778
Zhang, Wang, Kajino, Greene: VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells. in DNA and cell biology 2000
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Human Polyclonal vcp Primary Antibody für ICC, IF - ABIN151101
Dong, Bridges, Apsley, Xu, Weaver: ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. in Molecular biology of the cell 2008
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Xenopus laevis Monoclonal vcp Primary Antibody für WB - ABIN284668
Baron, Pedrioli, Tyagi, Johnson, Wood, Fountaine, Wightman, Alexandru: VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. in BMC biology 2014
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Xenopus laevis Monoclonal vcp Primary Antibody für WB - ABIN933553
Ernst, Mueller, Ploegh, Schlieker: The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. in Molecular cell 2009
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Human Polyclonal vcp Primary Antibody für FACS, IHC (p) - ABIN390907
Rush, Moritz, Lee, Guo, Goss, Spek, Zhang, Zha, Polakiewicz, Comb: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. in Nature biotechnology 2005
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Human Monoclonal vcp Primary Antibody für FACS, ICC - ABIN265891
Sullivan, Funk, Shan, Haroutunian, McCullumsmith: Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. in PLoS ONE 2015
Human Monoclonal vcp Primary Antibody für WB - ABIN1944899
Hu, Han, Song, Peng, Huang, Ren, Gu, Huang, Li, Jiang, Fu, Zhang, Gu, Dai, Mao, Gao, Rong, Ye, Zhou, Xu, Gu, Shi, Jin, Zhang, Wu, Huang, Chen, Chen, Chen: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. in Proceedings of the National Academy of Sciences of the United States of America 2000
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Human Monoclonal vcp Primary Antibody für ICC, FACS - ABIN269087
Greenhalgh, Griffith, Wald: The use of immunofluorescence in microdissection testicular sperm extraction. in Journal of andrology 2009
non-cell-autonomous effects of VCP-mutant astrocytes on both control and mutant Motor neurons, were examined.
AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts.
Data suggest ATXN3 (zeige ATXN3 Antikörper) binds with low-micromolar affinity to both wild-type p97/VCP and mutants linked to proteostasis deficiency multisystem proteinopathy 1 (MSP1; also called hereditary inclusion body myopathy); stoichiometry of binding is one ATXN3 (zeige ATXN3 Antikörper) molecule per p97/VCP hexamer in presence of ATP; MSP1 mutants of p97/VCP bind ATXN3 (zeige ATXN3 Antikörper) irrespective of nucleotide state. (VCP = valosin-containing protein/ATPase (zeige DNAH8 Antikörper); ATXN3 (zeige ATXN3 Antikörper) = ataxin-3 (zeige ATXN3 Antikörper))
a substantial proportion of the beta2AR (zeige ADRB2 Antikörper) produced is non-functional and VCP plays a key role in the maturation and trafficking of the beta2AR (zeige ADRB2 Antikörper).
When HEK293T cells were co-transfected with IQGAP1 (zeige IQGAP1 Antikörper) and VCP, an immunoprecipitation assay revealed that binding of IQGAP1 (zeige IQGAP1 Antikörper) with disease-related mutant (R155H or A232E) VCP was markedly reduced compared to wild-type VCP. This suggests that reduction of IQGAP1 (zeige IQGAP1 Antikörper) and VCP interaction may be associated with the pathophysiology of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD).
Rare variants in VCP genes are risk for sporadic inclusion body myositis.
Knockdown of the host ubiquitin-dependent segregase VCP/p97, results in loss of IE2 expression, subsequent suppression of early and late gene expression and, ultimately, failure in virus replication. NMS (zeige NMS Antikörper)-873, a small molecule inhibitor of VCP, is a potent HCMV antiviral with potential as a novel host targeting therapeutic for HCMV infection.
VCP removes sterically trapped Ku70/80 rings from DNA in double-strand break repair.
Data suggest that AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to wide range of cellular functions, including endoplasmic reticulum-associated degradation, membrane fusion, NFkappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation, and chromatin-associated processes, which are regulated by ubiquitination. [REVIEW]
Upon damage, p97 (zeige EIF4G2 Antikörper) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1 (zeige UBXN6 Antikörper), PLAA (zeige PLAA Antikörper), and the deubiquitinating enzyme YOD1 (zeige YOD1 Antikörper), which we term ELDR components for Endo-Lysosomal Damage Response.
Findings indicate that p97 plays a conserved role in dismantling the CMG (zeige CASK Antikörper) helicase (zeige DNA2 Antikörper) complex during different cellular events, but that distinct regulatory signals ultimately control when and where unloading takes place.
p97 is an essential regulator of DNA damage-dependent CDT1 (zeige CDT1 Antikörper) destruction
CDC-48/p97 coordinates CDT-1 (zeige CDT1 Antikörper) degradation with GINS chromatin dissociation to ensure faithful DNA replication
data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation
When we introduced CDC48 antisense morpholino oligonucleotides into zebrafish embryos, the morphant embryos were lethal and showed defects in neuronal outgrowth and neurodegeneration.
CDC48 may promote cell cycling and cell proliferation via C-terminal tyrosine phosphorylation during cold acclimation in fish cells
Together, these results suggested that mouse mammary tumor virus Rem (zeige REM1 Antikörper) uses a novel p97 (zeige EIF4G2 Antikörper)-dependent, Derlin-independent retrotranslocation mechanism distinct from other pathogens to avoid signal peptide ubiquitylation and proteasomal degradation.
cellular phenotypes caused by P137L mutant expression were not isolated observations, and some other IBMPFD disease-related VCP/p97 mutations could lead to similar outcomes
The functional motions of p97 (zeige EIF4G2 Antikörper) using symmetric normal modes have been predicted.
results suggest that (i) NLRP3 inflammasome and local IL-1beta((+))F4/80((+))Ly6C((+)) inflammatory macrophages contribute to pathogenesis of VCP-associated myopathy
VCP (valosin-containing protein), together with its cofactor P47 (zeige MFGE8 Antikörper) and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1 (zeige ATL1 Antikörper)), regulates tubular ER formation
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
Global expression profiling of VCP(R155H/+) mice identified key dysregulated signaling pathways including genes involved in the physiological system development and function, diseases and disorders, and molecular and cellular functions.
The results reveal an unexpected, crucial role of ATP consumption by VCP in determining cell fate in retinitis pigmentosa, and point to a promising new neuroprotective strategy for this currently incurable disease.
Pro(178) and Pro(183) of SelS (zeige SELS Antikörper) play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress
Knockdown or chemical inhibition of p97 (zeige EIF4G2 Antikörper) causes robust accumulation of USP33 (zeige USP33 Antikörper) due to inhibition of its degradation
results suggest that VCP plays a mechanistic role in releasing WRNp from the nucleolus
rescue experiments with a lethal mfap1 (zeige MFAP1 Antikörper) mutant show that the VCP binding region is not essential for Mfap1 (zeige MFAP1 Antikörper) function, but may act to increase its stability or activity
Clu (zeige CLU Antikörper) is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf (zeige MFN2 Antikörper) degradation in vitro Marf (zeige MFN2 Antikörper) accumulates in whole muscle lysates of clu (zeige CLU Antikörper)-deficient flies and is destabilized upon Clu (zeige CLU Antikörper) overexpression. Thus, Clu (zeige CLU Antikörper) is essential for mitochondrial homeostasis and functions in concert with Parkin (zeige PARK2 Antikörper) and VCP for Marf (zeige MFN2 Antikörper) degradation to promote damaged mitochondrial clearance.
results have revealed SUMOylation as a molecular signaling switch to regulate the distribution and functions of VCP during stress response, and suggest that deficiency in VCP SUMOylation caused by pathogenic mutations will render cells vulnerable to stress insults.
The authors propose that VCP sustains sarcoplasmic proteostasis, in part, by controlling the integrity of a dynamic tubular lysosomal network.
Ter94/VCP appears to be an evolutionarily conserved component that regulates BMP (zeige TGFb Antikörper)-Smad1 (zeige SMAD1 Antikörper)/5/8 signaling.
Data identifies that ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration (zeige CLN8 Antikörper) induced by knockdown of Caz, Drosophila FUS (zeige FUS Antikörper)
Valosin-Containing Protein has an essential role in dendrite pruning through regulating mRNA metabolism
VCP was validated as an atlastin (zeige ATL1 Antikörper)-interacting protein.
Ter94 ATPase (zeige DNAH8 Antikörper) and K11-linked ubiquitination in Ci contribute to the selectivity by proteasomes for partial degradation.
VCP binds to DIAP1 in a ubiquitin- and BIR domain-dependent manner and facilitates its degradation, therefore, establishing a new link between ubiquitin, dendrite pruning and the apoptosis machinery.
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
15S Mg(2+)-ATPase p97 subunit
, TER ATPase
, transitional endoplasmic reticulum ATPase
, valosin-containing protein
, yeast Cdc48p homolog
, p97 ATPase
, AAA ATPase p97
, Inv protein
, homolog of yeast cdc48
, valosin containing protein
, CG2331 gene product from transcript CG2331-RA
, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE TER94
, Valosin-Containing protein
, Valosin-containing protein homolog
, complementation group I
, transitional endoplasmic reticulum 94
, Fanconi anemia group G protein
, Fanconi anemia, complementation group G