This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008].
custom-made
EFNA1
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
EFNA1
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
EFNA1
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
custom-made
EFNA1
Spezies: Maus
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
custom-made
EFNA1
Spezies: Human
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Aktuelle Publikationen für unsere Ephrin A1 Proteine
Swidergall, Solis, Millet, Huang, Lin, Phan, Lazarus, Wang, Yeaman, Mitchell, Filler: "Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors." in: PLoS pathogens, Vol. 17, Issue 1, pp. e1009221, (2021) (PubMed).
Aaron, Jamklang, Uhrig, Gelli: "The blood-brain barrier internalises Cryptococcus neoformans via the EphA2-tyrosine kinase receptor." in: Cellular microbiology, Vol. 20, Issue 3, (2019) (PubMed).
Azimi, Tuominen, Costa Svedman, Caramuta, Pernemalm, Frostvik Stolt, Kanter, Kharaziha, Lehtiö, Hertzman Johansson, Höiom, Hansson, Egyhazi Brage: "Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells." in: Cell death & disease, Vol. 8, Issue 8, pp. e3029, (2018) (PubMed).