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Here we provide evidence that although wild type CtBP (zeige CTBP2 Proteine) negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP (zeige CTBP2 Proteine) unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP (zeige CTBP2 Proteine) in Dpp signaling in vivo.
CHES-1 (zeige FOXN3 Proteine)-like overexpression in germ cells activates dpp expression, inhibits spermatocyte differentiation, and finally leads to germ cell tumors.
Dpp activates signaling cascade involving dTak1 and JNK (zeige MAPK8 Proteine), to induce ectopic Mmp1 (zeige MMP1 Proteine) expression.
Results show that members of the Activin branch of the TGFbeta signaling pathway, namely Put and Smad2 (zeige SMAD2 Proteine), are autonomously required for cell and tissue growth in the Drosophila larval salivary gland.
ECM (zeige MMRN1 Proteine) over planar cell polarity mutant cells had reduced levels of laminin, Dally and Dlp (zeige DMD Proteine), and whereas Dpp-receiving ASP (zeige ASIP Proteine) cytonemes navigated in the Dally layer and required Dally (but not Dlp (zeige DMD Proteine)), FGF-receiving ASP (zeige ASIP Proteine) cytonemes navigated in the Dlp (zeige DMD Proteine) layer, requiring Dlp (zeige DMD Proteine) (but not Dally).
The authors show that Pent (zeige PNMT Proteine) internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp (zeige DMD Proteine)), and propose that this internalisation is important in the establishment of a long range Dpp gradient.
The expression of optix is activated by Dpp and repressed by the Spalt proteins, becoming restricted to the most anterior region of the wing blade.
En forms a complex with Nejire (zeige CREBBP Proteine) (Nej), the Drosophila ortholog of histone acetyltransferase CBP/p300 (zeige CREBBP Proteine), and directs Nej to this cis (zeige CISH Proteine)-regulatory region where Nej functions as the co-activator for dpp expression.
Basement membrane elimination, in contrast, attenuated signaling by bone morphogenetic protein/transforming growth factor beta ligand Dpp, which was not efficiently retained within the tissue and escaped to the body cavity.
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
TGF beta (zeige TGFB1 Proteine) is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 (zeige TGFB1 Proteine) and MMP-9 (zeige MMP9 Proteine) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo\; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development\; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.
, Decapentaplegic/Bone morphogenetic protein
, bone morphogenetic protein
, bone morphogenic protein
, DPP receptor
, activin receptor
, activin receptor type II
, dorsal holes C
, transforming growth factor beta-1
, transforming growth factor-beta