STAM Proteine (STAM)

Caenorhabditis elegans (C. elegans) Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) Interaktionspartner

1. These data reveal that the STAM-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 (zeige PCSK1 Proteine) receptor-TRPP2 complex.[STAM]

Human Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) Interaktionspartner

1. The beta-arrestin1.STAM1 complex is necessary for promoting autophosphorylation of focal adhesion kinase (FAK). FAK is necessary for CXCL12-induced chemotaxis and associates with and localizes with beta-arrestin1 and STAM1 in a CXCL12-dependent manner.

2. The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains

3. Differential expression of the transcripts STAM connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.

4. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.

5. Overexpression of an AIP4 (zeige ITCH Proteine) catalytically inactive mutant and a mutant that shows poor binding to STAM-1 fails to enhance CXCR4 (zeige CXCR4 Proteine)-induced ERK-1 (zeige MAPK3 Proteine)/2 signaling.

6. STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.

7. Interaction of TIMM8a (zeige TIMM8A Proteine) with STAM1.

8. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM1 function in early endosome.

9. Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins

10. Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor (zeige NTRK1 Proteine) signalling through a common element.

Mouse (Murine) Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) Interaktionspartner

1. the motor neuron-specific ISL1 (zeige ISL1 Proteine)-LHX3 (zeige LHX3 Proteine) complex directly transactivates the Stam1 gene.

2. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.

3. These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.

4. Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins