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These findings suggest that SRA genetic variants may contribute to breast cancer risk
The studies suggest that MNK (zeige ATP7A Proteine)-eiF4E (zeige EIF4E Proteine) axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1 (zeige CYFIP1 Proteine). (Review)
rs4778298, a common variant at CYFIP1 (zeige CYFIP1 Proteine) is associated with inter-individual variation in surface area across the left supramarginal gyrus.
we show that stapled peptides targeting the interface between NCKAP1 (zeige NCKAP1 Proteine) and CYFIP1 (zeige CYFIP1 Proteine) destabilize the WASF3 (zeige WASF3 Proteine) complex... thereby suppressing invasion and metastasis of breast cancer cells.
SRA1 was down expressed in HCC (zeige FAM126A Proteine) and its level was associated with tumor size and GLU (zeige DCTN1 Proteine) level in patients with HCC (zeige FAM126A Proteine) for the first time. SRA1 may be a helpful biomarker to diagnostic HCC (zeige FAM126A Proteine).
By studying a cohort of idiopathic hypogonadotropic hypogonadism, our findings strongly suggest that SRA1 gene function is required for initiation of puberty in humans
Results identified H15-H18 domains in SRA gene playing a key role in regulating ER-mediated transcription.
Both mRNA and protein expression levels of Cyfip1 (zeige CYFIP1 Proteine) were significantly lower in ALL patients.
in human pluripotent stem cells SRA interacts with NANOG and is important for maintenance of the pluripotent state.
Reduced CYFIP1 (zeige CYFIP1 Proteine) in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks.
Visfatin (zeige NAMPT Proteine) upregulated CD36 (zeige CD36 Proteine) and SRA (zeige MSR1 Proteine) expression and downregulated ABCA1 (zeige ABCA1 Proteine) and ABCG1 (zeige ABCG1 Proteine) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (zeige EPHB2 Proteine)-dependent pathways.
The results of this study demonstrated that SRA (zeige MSR1 Proteine) could attenuate microglia mediated inflammation injury in ICH (zeige ACE Proteine). In addition, SRA (zeige MSR1 Proteine) mediated negative feedback mechanism in neuroimmune homeostasis.
these data are the first to indicate a functional role for SRA (zeige MSR1 Proteine) in adipose tissue biology and glucose homeostasis in vivo.
Dax1 (zeige NR0B1 Proteine) augmentation of LRH-1 (zeige NR5A2 Proteine)-mediated Oct4 (zeige POU5F1 Proteine) activation is dependent upon steroid receptor (zeige ESR2 Proteine) RNA activator
DEAD-box RNA helicase (zeige DDX56 Proteine) p68 (DDX5 (zeige DDX5 Proteine)) and its associated noncoding RNA, steroid receptor (zeige ESR2 Proteine) RNA activator (SRA (zeige MSR1 Proteine)), form a complex with CTCF (zeige CTCF Proteine) that is essential for insulator function
Steroid receptor (zeige ESR2 Proteine) RNA activator stimulates proliferation as well as apoptosis in vivo
Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (zeige RARA Proteine) (mRAR)gamma when coexpressed with steroid receptor (zeige ESR2 Proteine) RNA activator.
both MARCO (zeige MARCO Proteine) and SR-A (zeige MSR1 Proteine) could be involved in the positioning and differentiation of macrophages, possibly through interaction with endogenous ligands
These findings reveal novel functions of SRA (zeige MSR1 Proteine) and Dax-1 (zeige NR0B1 Proteine) in steroidogenesis and adrenal biology.
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
steroid receptor RNA activator 1 (complexes with NCOA1)
, steroid receptor RNA activator protein
, steroid receptor coactivator
, steroid receptor RNA activator 1
, cytoplasmic FMR1-interacting protein 1
, cytoplasmic FMRP interacting protein 1
, selective hybridizing clone
, specifically Rac1-associated protein 1