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Data show that the gene encoding the transcription factor SOX9 was identified by a global transcriptomic approach as an HDAC9 (zeige HDAC9 ELISA Kits) target gene.
SOX9 is a proliferation and stem cell factor (zeige KITLG ELISA Kits) in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types
Sox9 and Ngn3 (zeige NEUROG3 ELISA Kits), key transcription factors associated with pancreatic development.
Expression of bone morphogenetic protein (BMP) 4, an upstream stimulator of SOX9, was upregulated by CG.
Xenogeneic implantation of Sox9-overexpressing hUCMSCs embedded in the BMG/fibrin scaffolds promotes the formation of cartilage-like tissue without inducing evident host immune response. Therefore, Sox9-overexpressing hUCMSCs represent a promising cell candidate for cartilage tissue engineering.
KLF15 (zeige KLF15 ELISA Kits) activates SOX9 expression directly. SOX9 is involved in KLF15 (zeige KLF15 ELISA Kits) function during chondrogenic differentiation.
Tomo-Seq Identifies SOX9 as a Key Regulator of Cardiac Fibrosis During Ischemic Injury
High SOX9 expression is associated with glioblastoma.
These findings suggest that SOX9 may play an important role in tumor progression of Renal Cell Carcinoma and Bladder Cancer and it may be used as a biomarker of this malignancy.
Loss of DDRGK1 decreases SOX9 expression and causes a human skeletal dysplasia.
data presented here demonstrate that the 18 bp indel in the porcine SOX9 5'-UTR (zeige UTS2R ELISA Kits) is of functional importance and may therefore indeed be a causative variation in SOX9 associated traits
HIF-1alpha (zeige HIF1A ELISA Kits) activates Sox9 expression and enhances Sox9-mediated transcriptional activity.
Hypomethylation in the Sox9 promoter is correlated to increased Sox9 expression in db/db (zeige LEPR ELISA Kits) IESCs. Although there is increased expression of Sox9 in db/db (zeige LEPR ELISA Kits) IESCs, the loss of Sox9 transcriptional activation in specific repressors of the Wnt (zeige WNT2 ELISA Kits) signaling pathway might result in abnormalities in this pathway.
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9, together with Sox8 (zeige SOX8 ELISA Kits) and coordinately with Dmrt1 (zeige DMRT1 ELISA Kits), also controls adult testis maintenance.
SOX9 regulation of ETV5 contributes to the control of male fertility
Nuclear factors that bind to genomic regions with "Sertoli Cell Signature" could functionally interact with SOX9; TRIM28 (zeige TRIM28 ELISA Kits) is a new SOX9 partner in fetal testes.
Down-regulated expression of Sox9 and Dazl (zeige DAZL ELISA Kits) may play important roles in MBP (zeige MBP ELISA Kits)-induced testis injury.
Sox9 is positively regulated by mesenchymal Fgf10 (zeige FGF10 ELISA Kits), a process that requires active Erk (zeige EPHB2 ELISA Kits) signaling during salivary gland development
TSC1 (zeige TSC1 ELISA Kits)/TSC2 (zeige TSC2 ELISA Kits) complex upregulation of OPN (zeige SPP1 ELISA Kits) expression is mediated by transcription factor SOX9 in an mTOR (zeige FRAP1 ELISA Kits)-independent manner. Moreover, ablation of OPN (zeige SPP1 ELISA Kits) by deficient TSC1 (zeige TSC1 ELISA Kits)/TSC2 (zeige TSC2 ELISA Kits) complex contributed to inactivation of AKT (zeige AKT1 ELISA Kits) in TSC (zeige SLC12A3 ELISA Kits) cells
SOX9 is almost exclusively expressed by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX9 is also expressed by neural progenitor cells
hese findings indicate that chronic overexpression of Sox9 in the uterine epithelium can induce the development of endometrial hyperplastic lesions. Thus, SOX9 expression may be a factor in the formation of endometrial cancer.
The conditional ablation of Sox9 in the genital tubercle using Shh (zeige SHH ELISA Kits)-Cre/+;Sox9(flox/flox) mice revealed no genital tubercle abnormalities, possibly due to compensation by similar Sox (zeige QSOX1 ELISA Kits) factors.
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
SRY (sex determining region Y)-box 9
, SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)
, transcription factor SOX-10
, SRY (sex-determining region Y)-box 9 protein
, SRY-related HMG-box, gene 9
, transcription factor SOX-9
, SRY-box containing protein 9
, SRY-box containing gene 9
, transcription factor SOX9