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Transcriptional regulation of NOX genes expression in human breast adenocarcinoma cells is modulated by adaptor protein CIN85.
The multiple Src (zeige SRC Proteine) homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 (zeige BLNK Proteine) molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process.
these data support a role for the novel PP2Ac (zeige PPP2CA Proteine)-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
CIN85 promotes recycling of TGF-beta (zeige TGFB1 Proteine) receptors and thereby positively regulates TGF-beta (zeige TGFB1 Proteine) signaling.
we demonstrate that SEPT9 (zeige SEPT9 Proteine) negatively regulates EGFR (zeige EGFR Proteine) degradation by preventing the association of the ubiquitin ligase Cbl (zeige CBL Proteine) with CIN85, resulting in reduced EGFR (zeige EGFR Proteine) ubiquitylation
Results support the model that Cbl (zeige CBL Proteine)-CIN85-endophilin complex is not required for efficient internalization of EGFR (zeige EGFR Proteine), a prototype RTK.
Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma cell line.
LOX (zeige LOX Proteine)-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells.
an FRS2beta (zeige FRS3 Proteine)-CIN85/CD2AP (zeige Cd2ap Proteine)-Cbl (zeige CBL Proteine) axis for downregulation of ErbB2 (zeige ERBB2 Proteine) may regulate ErbB2 (zeige ERBB2 Proteine) protein levels in physiological and pathological settings
Data show that EGFR (zeige EGFR Proteine) activation leads to a pronounced src (zeige SRC Proteine)-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR (zeige EGFR Proteine) ubiquitination.
Cin85-deficient mother mice had reduced pituitary hormone (zeige CGA Proteine) prolactin (zeige PRL Proteine) secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited.
competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 (zeige ARAP1 Proteine) could compete with Cbl (zeige CBL Proteine) for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 (zeige ARAP1 Proteine) in the CIN85-mediated EGFR (zeige EGFR Proteine) internalizing process.
CIN85/RukL is involved in endocytosis of nephrin (zeige NPHS1 Proteine) in podocytes under diabetic conditions, causing podocyte depletion and promoting proteinuria. CIN85/RukL expression therefore shows potential to be a novel target for antiproteinuric therapy in diabetes.
Dab1 (zeige DAB1 Proteine) mediated the association of CIN85 with ApoER2 (zeige LRP8 Proteine) or VLDLR (zeige VLDLR Proteine) in neurons.
Data suggest that Ser587 Cin85 phosphomimetic mutant protein shows dramatically reduced binding to Dab1 (zeige DAB1 Proteine) (disabled protein 1) (without affecting binding to CapZ (zeige CAPZA1 Proteine)).
Sh3kbp1 is SUMOylated by SUMO-1 (zeige SUMO1 Proteine), -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap (zeige Cd2ap Proteine).
the interaction between SHIP-1 (zeige INPP5D Proteine) and CIN85 might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 (zeige BLNK Proteine) and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
a B cell-specific deletion of CIN85 led to impaired T cell-independent type II antibody responses in vivo and diminished IKK-beta (zeige IKBKB Proteine) activation and cellular responses to B (zeige TDO2 Proteine) cell receptor cross-linking in vitro
Coexpression of CIN85/Ruk(L) with CD2AP (zeige Cd2ap Proteine) led to a decreased binding of CIN85/Ruk(L) to nephrin (zeige NPHS1 Proteine) and podocin, which indicates a functional competition between CD2AP (zeige Cd2ap Proteine) and CIN85/Ruk(L).
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
SH3-domain kinase binding protein 1
, SH3 domain-containing kinase-binding protein 1-like
, CD2-binding protein 3
, SH3 domain-containing kinase-binding protein 1
, Src family kinase-binding protein 1
, c-Cbl-interacting protein
, cbl-interacting protein of 85 kDa
, human Src family kinase-binding protein 1
, migration-inducing gene 18
, src-related kinase binding protein-1
, SH3-containing, expressed in tumorigenic astrocytes
, Sh3 containing, expressed in astrocytes
, regulator of ubiquitous kinase
, SH3 domain-containing adapter protein