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transferred nuclear Overhauser effects (trNOEs) have been employed in the docking program HADDOCK to generate models for the LAR-fondaparinux complex. These models are further analyzed by postprocessing energetic analysis to identify key binding interactions.
PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting.
Homozygous truncating PTPRF mutation causes athelia.
PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development.
Interaction between the tripartite NGL-1 (zeige LRRC4C Proteine), netrin-G1 (zeige NTNG1 Proteine) and LAR adhesion complex promotes development of excitatory synapses.
LAR functions as a negative regulator of adipogenesis.
Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3 (zeige LRRC4B Proteine)) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (zeige PTPRD Proteine) (PTPdelta), and PTPsigma (zeige PTPRS Proteine) via specific domains regulate excitatory synapse formation.
regulation of expression by cell density through functional E-cadherin (zeige CDH1 Proteine) complexes
interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs (zeige PTPRS Proteine)
LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation
loss of LAR activity resulted in reduced activity of CDK1 (zeige CDK1 Proteine).
Study has identified LAR as a regulator of key signaling pathways, including mTOR (zeige FRAP1 Proteine) and JNK (zeige MAPK8 Proteine), and has significantly expanded the number of proteins regulated downstream of LAR phosphatase activity.
Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPsigma (zeige PTPRS Proteine) and Modulation of the Rho/ROCK Pathway.
This study demonstrates the crucial role of LAR in restricting regrowth of injured CNS axons
Ptprs (zeige PTPRS Proteine) and Ptprf deficiency affects mandibular cell proliferation.
Inhibition of LAR attenuates palmitate-induced insulin (zeige INS Proteine) resistance in myotubes.
Deletion of LAR in knock-out mice or blockade of LAR with sequence-selective peptides significantly overcomes neurite growth restrictions of chondroitin sulfate proteoglycan (zeige Vcan Proteine) in neuronal cultures.
the crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa receptor Dlar and its mouse homolog LAR were reported.
LAR reduces the basal c-Abl activity thereby allowing for platelet derived growth factor beta receptor kinase activation
LAR deficiency affected the differentiation & expansion of immature thymocytes, positive & negative selection, & a lower Ca2+ response. LAR is an important modulator of TCR signaling that controls thymocyte differentiation.
Presynaptic PTPsigma (zeige PTPRS Proteine) controls the number of olfactory sensory neuron and mitral cell synapses by suppressing excessive increase of axon terminals.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
, leukocyte antigen-related (LAR) PTP receptor
, leukocyte antigen-related tyrosine phosphatase
, leukocyte common antigen related
, protein tyrosine phosphatase, receptor type, F polypeptide
, receptor-linked protein-tyrosine phosphatase LAR
, receptor-type tyrosine-protein phosphatase F
, protein tyrosine phosphatase receptor-type F