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Human Mesothelin Protein expressed in Wheat germ - ABIN1311459
Chang, Chen, Chen, Chiang, Chen, Mao, Lin, Lin Chiang, Cheng: Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. in The Biochemical journal 2012
Mesothelin-targeted immunotoxin RG7787 increases pancreatic cancer cell sensitivity to taxane-mediated killing by increasing taxane-mediated microtubule stability and priming cells for apoptosis by decreasing levels of the pro-survival factor Mcl-1 (zeige MCL1 Proteine).
RG7787 plus nab-paclitaxel is very active against primary human mesothelioma cells in vitro as well as in vivo, with serum mesothelin levels correlating with tumor response. These results indicate that this combination could be useful for treating patients with mesothelioma
Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells.
Mesothelin/mucin 16 (zeige MUC16 Proteine) signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
MiR (zeige MLXIP Proteine)-21-5p is suggested as novel regulator of MSLN with a possible functional role in cellular growth.
we report herein that high tumor mesothelin expression predicts a shorter PFS and OS in EOC patients and demonstrates that serum mesothelin predicts local tumor mesothelin expression.
We provide new evidence for the role of MSLN in EMT (zeige ITK Proteine) regulation, tumorigenesis and metastasis. Knockdown of MSLN led to mesenchymal to epithelial transition and less aggressive behavior of lung carcinoma and mesothelioma cells.
MSLN expression increases cell migration and invasion in vitro.
SMRP (zeige ABCC5 Proteine) but not FBLN3 (zeige FBLN3 Proteine) has a role in pleural effusions in in malignant pleural mesothelioma
High mesothelin expression is associated with malignant pleural mesothelioma.
Study demonstrates that selective activation of G protein-coupled estrogen receptor (zeige ESR1 Proteine) can control microglial activation induced by an inflammatory stimulus in vitro, and promote neuronal and functional protection of DA neurons against a unilateral intranigral injection of LPS (zeige TLR4 Proteine) in male mice.neuroinflammatory diseases.
our findings show that Sulf-1 (zeige SULF1 Proteine) is an important tumor suppressor gene in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), and its over expression downregulates Msln and results in a decrease in HCC (zeige FAM126A Proteine) cell proliferation, migration, invasion, and lymphatic metastasis.
it suppresses lipopolysaccharide-induced interleukin 6 (zeige IL6 Proteine) via inhibition of nuclear factor-kappa B pathway in murine macrophage cells
this study revealed a role for GPER activity in regulating Nox1 (zeige NOX1 Proteine) abundance and associated O2(-)-mediated structural and functional damage that contributes to disease pathology
These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.
GPER protects against hepatic tumorigenesis by regulating inflammatory responses.
Data suggest that prenatal exposure to p,p'-DDT (zeige DDT Proteine) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (zeige DDT Proteine)-induced depressive-like neurotoxicity.
Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (zeige AKT1 Proteine) signaling for Ask1 (zeige MAP3K5 Proteine) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (zeige ESR2 Proteine) and the G protein-coupled estrogen receptor (zeige ESR1 Proteine).
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.
, megakaryocyte potentiating factor
, pre-pro-megakaryocyte-potentiating factor
, soluble MPF mesothelin related protein
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, chemoattractant receptor-like 2
, constitutively expressed peptide-like receptor like
, membrane estrogen receptor
, protein expressed in renal carcinoma