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anti-Mouse (Murine) GRB7 Antikörper:
anti-Rat (Rattus) GRB7 Antikörper:
anti-Human GRB7 Antikörper:
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Human Polyclonal GRB7 Primary Antibody für ELISA, WB - ABIN249513
Margolis, Silvennoinen, Comoglio, Roonprapunt, Skolnik, Ullrich, Schlessinger: High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. in Proceedings of the National Academy of Sciences of the United States of America 1992
GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR (zeige MLXIP Antikörper)-193.
Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR (zeige EGFR Antikörper)-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
The adaptor Grb7 links netrin-1 (zeige NTN1 Antikörper) signaling to regulation of mRNA translation of kappa opioid receptor (zeige OPRK1 Antikörper).
Grb7 is identified as an integral component of stress granules.
Study provided a direct link between the signal adapter protein (zeige TOLLIP Antikörper) Grb7, anti-apoptotic protein Hax1 (zeige HAX1 Antikörper) isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1 (zeige HAX1 Antikörper)-related apoptosis pathways mediated by Caspase3.
Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization.
Grb7 was found to be significantly related to the biological classification of breast cancer
apo (zeige C9orf3 Antikörper) Grb7 SH2 domain crystallized in the trigonal space group P63 (zeige RPE65 Antikörper), whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21 (zeige CDKN1A Antikörper)
The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2 (zeige ERBB2 Antikörper)+ve cell types
Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton.
Data suggest that calmodulin controls Grb7-mediated cell migration.
Data propose the phosphorylation state of Grb7-SH2 domain tyrosine residues could control Grb7 dimerization, and dimerization may be an important regulatory step in Grb7 binding to RTKs such as erbB2 (zeige ERBB2 Antikörper).
GRB7 is a context-dependent oncogene (zeige RAB1A Antikörper), which modulates the ERBB2 (zeige ERBB2 Antikörper) signaling pathway through enhanced phosphorylation of ERBB2 (zeige ERBB2 Antikörper) and Akt (zeige AKT1 Antikörper).
propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS (zeige ALDH1A2 Antikörper)
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
growth factor receptor-bound protein 7
, growth factor receptor-bound protein 7-like
, GRB7 adapter protein
, Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7)
, epidermal growth factor receptor GRB-7
, growth factor receptor binding protein GRB7