CBLC Proteine (CBLC)

Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C (CBLC) Interaktionspartner

1. only the SH3 domains of CD2AP (zeige Cd2ap Proteine) are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51 (zeige RET Proteine)

2. Accumulation of c-Cbl (zeige CBL Proteine) and rapid termination of colony-stimulating factor 1 receptor (zeige CSF1R Proteine) signaling in interferon consensus sequence binding protein (zeige IRF8 Proteine)-deficient bone marrow-derived macrophages

3. Results describe the detailed expression pattern of murine Cbl-3 and report the generation and characterization of Cbl-3-deficient mice.

4. c-Cbl (zeige CBL Proteine) deficiency did not affect Fc epsilon RI-induced histamine release or total cellular protein phosphorylation. Its absence increased ERK (zeige EPHB2 Proteine) phosphorylation after receptor stimulation, but resulted in reduced p38 (zeige CRK Proteine) phosphorylation & Ca(2 (zeige CA2 Proteine)+) response.

5. MMTV-CBLC transgenic mice show abnormal mammary gland development

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C (CBLC) Interaktionspartner

1. Methylmalonic aciduria with homocystinuria cblC is a multisystemic metabolic disease affecting cobalamin metabolism. The presence of retinal alterations in cblC is a common feature and it is reported to develop more frequently and into a more severe form in the early-onset phenotype, suggesting to some extent a correlation with the biochemical phenotype

2. Data suggest that ubiquitin ligase CBLC controls mostly network organization of the Golgi Apparatus.

3. Silencing of CBLC causes increased sensitivity to PARP1 (zeige PARP1 Proteine) inhibitor olaparib in breast cancer cell line models and that defective homologous recombination (HR) DNA repair is the likely cause.

4. the effects of two pathogenic missense mutations on the the catalytic activities of the human B12 (zeige NDUFB3 Proteine)-processing chaperone CblC

5. This retrospective multicentre study evaluates clinical, biochemical and genetic findings in 88 cblC patients

6. The ubiquitin ligase activity of Cbl (zeige CBL Proteine)-c by the direct interaction of the LIM (zeige PDLIM5 Proteine) zinc coordinating domain of Hic5 (zeige TGFB1I1 Proteine) is demonstrated.

7. the N terminus of Cbl (zeige CBL Proteine)-c contributes to the binding to the E2 and phosphorylation of Tyr (zeige TYR Proteine)-341 leads to a decrease in affinity and an increase in the E3 activity of Cbl (zeige CBL Proteine)-c

8. Data demonstrate that two E3 ligases of different classes, CBLC and AIP4 (zeige ITCH Proteine), can interact and cooperate to down-regulate EGFR (zeige EGFR Proteine) signaling.

9. c-Cbl is a negative regulator of hepatocyte growth factor/receptor tyrosine kinase Met signaling in B cells, mediating ubiquitination and, consequently, proteosomal degradation of Met, with a role in Met-mediated tumorigenesis.

10. Src (zeige SRC Proteine) is a preferential target of Cbl (zeige CBL Proteine)-c for degradation