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vanillin binds strongly to the active site cavity of CAMKIV and stabilized by a large number of non-covalent interactions.
Genotype and allele frequencies of CAMKIV gene SNPs differed significantly between alcohol dependence patients and control subjects. The results of the present study suggest that CAMKIV might be a candidate alcohol dependence gene.
hTau accumulation impairs synapse and memory by CaN-mediated suppression of nuclear CaMKIV/CREB signaling.
Within the pH range 5.0-11.5, CAMK4 maintained both its secondary and tertiary structures, along with its function, whereas significant aggregation was observed at acidic pH (2.0-4.5).
A positive association was not observed between rs10491334 in the CAMK4 gene and longevity in a Chinese population.
The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group.
Expression of CaMKIV inhibits autophosphorylation and activation of CaMKII, and elicits G0/G1cell cycle arrest,impairing cell proliferation.
An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders.
CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance.
CaMK4 regulates beta-cell proliferation and apoptosis in a CREB-dependent manner and CaMK4-induced IRS-2 expression is important in these processes
study suggests that the mutations in CAMK4 may lead to abnormal semen parameters
Phosphorylated Notch1-IC by CaMKIV increases Notch1-IC stability, which enhances osteoclast differentiation.
Prolongevity genes are activated by CAMKIV, the levels of which are influenced by rs10491334, a single-nucleotide polymorphism associated with human longevity.
The regulation of RORalpha activity by PKA as well as CaMK-IV provides a new link in the signalling network that regulates metabolic processes such as glycogen and lipid metabolism.
These findings suggest that PLC/CAMK IV-NF-kappaB is involved in RAGE mediated signaling pathway in human endothelial cells.
CaMKIV proteins were found in the nucleus of epithelial ovarian cancer tissue. CaMKIV expression was significantly associated with clinical stage (P<0.01), histological grade (P<0.01), and clinical outcome (P<0.01).
sequestration of CaMKK may be the molecular mechanism by which catalytically inactive mutants of CaMKIV exert their "dominant-negative" functions within the cell
the Ca(2+)/CaM binding-autoinhibitory domain of CaMKIV is required for association of the kinase with PP2A
calcium/CaMKIV signaling pathway may play an important role in the excitation-mediated regulation of corticotropin releasing hormone synthesis
the function of CaMK II is essential for PAF-induced macrophage priming, while CaMK IV is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events
Data suggest that Tyr(99) phosphorylated calmodulin, as compared to non-phosphorylated, binds with a higher affinity at the calmodulin binding site (rich in basic amino acids) of CaM kinase IV leading to increased activation of CaM kinase IV.
conclude that the hypoxia-induced increased activation of CaM kinase IV cascade increases with the increase in the degree of cerebral tissue hypoxia as measured by cerebral tissue high energy phosphates in a curvilinear manner
both CaMKII autophosphorylation and CaMKIV phosphorylation significantly decreased in hippocampal CA1 regions of NCKX2+/- relative to control mice.
CaMKIV can act as an immunostimulation molecule and enhances the acute muscle inflammatory responses.
CaMKIV knockdown selectively inhibits pro-inflammatory cytokines/chemokines, and co-stimulatory molecules expression in IFN-gamma treated myoblasts and myotubes and abolishes IFN-gamma induced CREB pathway molecules accumulation in differentiated myotubes.
Activation of CaMKIV by soluble amyloid-beta1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis.
CaMKIV is a key regulator of neuronal intracellular HDAC4 trafficking during stroke
Pharmacological inhibition of CaMK4 recapitulated the observed defects in Cryptococcus neoformans phagocytosis. Furthermore, mice deficient in CaMK4 showed increased survival compared to wild-type mice upon infection with Cryptococcus neoformans. This increase in survival correlated with decreased expression of pattern recognition receptors on host phagocytes known to recognize Cryptococcus neoformans.
results imply that CaMKIV plays a role in maintenance the structure of chromatoid body by regulating the associations of proteins in it
CaMK4 activity is increased in T cells from systemic lupus erythematosus mice compared with the control group.
Results demonstrated that genetically inhibiting the CaMKK pathway via CaMKKbeta or CaMK IV is detrimental in the response of female mice to cerebral ischemia
CaMKIV-mTOR-dependent autophagy is conserved in both immune and nonimmune/parenchymal cells and is fundamental for the respective functional and adaptive responses to septic insult.
The stimulation of CaMKII activity in the hippocampus is essential for rivastigmine-induced memory improvement in olfactory bulbectomized mice.
CaMKK/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia.
CaMKIV has opposing roles in nicotine and cocaine reward.
The reduced fertility of Crybb2 knockout male mice may result from the disordered proliferation and apoptosis of germ cells in the testis, possibly due to reduced CaMKIV from the loss of Crybb2.
High levels of Camk4-encoding transcripts are found in T lymphocytes, particularly CD4+ T cells, of MRL/lpr lupus-prone mice.
the protective autophagic signaling pathway serves to reduce organ damage following ischemia-reperfusion and is regulated by activation of calcium-calmodulin-dependent protein kinase type 4 signaling in hepatocytes.
we demonstrated that calcium/calmodulin-dependent protein kinase type IV spontaneous and platelet-derived growth factor-stimulated mesangial cell proliferation
Calcium/Calmodulin-dependent kinase IV specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91.
We identified the zebrafish homologue of CaMKIV (zCaMKIV) on the basis of biochemical characterization. zCaMKIV showed similar biochemical properties as well as tissue and subcellular distributions to rat CaMKIV (rCaMKIV)
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
CAM kinase IV
, CAM kinase- GR
, brain Ca(2+)-calmodulin-dependent protein kinase type IV
, brain Ca++-calmodulin-dependent protein kinase type IV
, caM kinase-GR
, calcium/calmodulin-dependent protein kinase type IV
, calcium/calmodulin-dependent protein kinase type IV catalytic chain
, calcium/calmodulin-dependent protein kinase IV
, calcium/calmodulin-dependent protein kinase type IV-like
, CAM kinase-GR
, Ca2+/calmodulin-dependent protein kinase type IV/Gr
, caMK IV
, Calmodulin-dependent protein kinase IV