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vanillin binds strongly to the active site cavity of CAMKIV and stabilized by a large number of non-covalent interactions.
Genotype and allele frequencies of CAMKIV gene SNPs differed significantly between alcohol dependence patients and control subjects. The results of the present study suggest that CAMKIV might be a candidate alcohol dependence gene.
hTau accumulation impairs synapse and memory by CaN-mediated suppression of nuclear CaMKIV/CREB (zeige CREB1 Proteine) signaling.
Within the pH range 5.0-11.5, CAMK4 maintained both its secondary and tertiary structures, along with its function, whereas significant aggregation was observed at acidic pH (2.0-4.5).
A positive association was not observed between rs10491334 in the CAMK4 gene and longevity in a Chinese population.
The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group.
Expression of CaMKIV inhibits autophosphorylation and activation of CaMKII (zeige CAMK2G Proteine), and elicits G0/G1cell cycle arrest,impairing cell proliferation.
An imbalance of specific isoforms of CYFIP1 (zeige CYFIP1 Proteine), an FMRP (zeige FMR1 Proteine) interaction partner, and CAMK4, a transcriptional regulator of the FMRP (zeige FMR1 Proteine) gene, modulates risk for autism spectrum disorders.
CaMK4-dependent activation of AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) and CREM (zeige CREM Proteine)-alpha underlies autoimmunity-associated Th17 imbalance.
CaMK4 regulates beta-cell proliferation and apoptosis in a CREB (zeige CREB1 Proteine)-dependent manner and CaMK4-induced IRS-2 (zeige IRS2 Proteine) expression is important in these processes
Data suggest that Tyr (zeige TYR Proteine)(99) phosphorylated calmodulin, as compared to non-phosphorylated, binds with a higher affinity at the calmodulin binding site (rich in basic amino acids) of CaM kinase IV leading to increased activation of CaM kinase IV.
conclude that the hypoxia-induced increased activation of CaM kinase IV cascade increases with the increase in the degree of cerebral tissue hypoxia as measured by cerebral tissue high energy phosphates in a curvilinear manner
CaMKIV can act as an immunostimulation molecule and enhances the acute muscle inflammatory responses.
CaMKIV knockdown selectively inhibits pro-inflammatory cytokines/chemokines, and co-stimulatory molecules expression in IFN-gamma (zeige IFNG Proteine) treated myoblasts and myotubes and abolishes IFN-gamma induced (zeige SAMHD1 Proteine) CREB (zeige CREB1 Proteine) pathway molecules accumulation in differentiated myotubes.
Activation of CaMKIV by soluble amyloid-beta1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis.
CaMKIV is a key regulator of neuronal intracellular HDAC4 (zeige HDAC5 Proteine) trafficking during stroke
Pharmacological inhibition of CaMK4 recapitulated the observed defects in Cryptococcus neoformans phagocytosis. Furthermore, mice deficient in CaMK4 showed increased survival compared to wild-type mice upon infection with Cryptococcus neoformans. This increase in survival correlated with decreased expression of pattern recognition receptors on host phagocytes known to recognize Cryptococcus neoformans.
results imply that CaMKIV plays a role in maintenance the structure of chromatoid body by regulating the associations of proteins in it
CaMK4 activity is increased in T cells from systemic lupus erythematosus mice compared with the control group.
Results demonstrated that genetically inhibiting the CaMKK (zeige CAMKK2 Proteine) pathway via CaMKKbeta or CaMK IV is detrimental in the response of female mice to cerebral ischemia
CaMKIV-mTOR (zeige FRAP1 Proteine)-dependent autophagy is conserved in both immune and nonimmune/parenchymal cells and is fundamental for the respective functional and adaptive responses to septic insult.
We identified the zebrafish homologue of CaMKIV (zCaMKIV) on the basis of biochemical characterization. zCaMKIV showed similar biochemical properties as well as tissue and subcellular distributions to rat CaMKIV (rCaMKIV)
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
CAM kinase IV
, CAM kinase- GR
, brain Ca(2+)-calmodulin-dependent protein kinase type IV
, brain Ca++-calmodulin-dependent protein kinase type IV
, caM kinase-GR
, calcium/calmodulin-dependent protein kinase type IV
, calcium/calmodulin-dependent protein kinase type IV catalytic chain
, calcium/calmodulin-dependent protein kinase IV
, calcium/calmodulin-dependent protein kinase type IV-like
, CAM kinase-GR
, Ca2+/calmodulin-dependent protein kinase type IV/Gr
, caMK IV
, Calmodulin-dependent protein kinase IV