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anti-Human ADCY3 Antikörper:
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Human Polyclonal ADCY3 Primary Antibody für ELISA, IHC - ABIN2746156
Bazhin, Kahnert, Kimpfler, Schadendorf, Umansky: Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells. in Molecular immunology 2010
Human Polyclonal ADCY3 Primary Antibody für ICC, IF - ABIN4278416
Quinn, Graves, Dains-McGahee, Friedman, Hassan, Witkowski, Sabbatini: Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells. in Molecular carcinogenesis 2016
ADCY3 is an important mediator of energy homeostasis and an attractive pharmacological target in the treatment of obesity.
MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons; obesity-associated MC4R mutations impair ciliary localization and inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight.
An enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts.
This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet.
In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops.
Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase
The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene.
Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism.
endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3
Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons.
This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder.
Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population.
identified AC3as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation
expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules
Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade.
Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction.
This the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes.
These results suggest that the length of primary cilia is controlled, at least in part, by the adenylate cyclase III-cAMP signaling pathway.
Cell apoptosis in the testicular tissues of AC3(-/-) mice increased significantly compared with that in wild-type (AC3(+/+)) mice. The expression of 693 genes was altered in the testicular tissues of AC3(-/-) mice, including 330 up-regulated and 363 down-regulated gene expression, helping to elucidate the mechanisms underlying the sterility in AC3(-/-) male mice.
AC3 may play a role in proximal olfactory signaling and play a role in the regulation of differentially expressed genes in mouse MOE.
genetic ablation of adenylate cyclase III has drastic, location-dependent effects on cilia architecture in the mouse nose
Data showed the presence mRNA of obligated downstream components of olfactory receptor signaling adenylyl cyclase 3 and olfactory G protein in the cerebral cortex of the mouse.
increased Adcy3 activity robustly protect animals from diet-induced metabolic derangements
Study identifies the transient expression of histone demethylase LSD1 and the OR-dependent expression of adenylyl cyclase 3 as requirements for initiation and stabilization of OR expression.
Coexpression of serotonin receptor 5HT6 with adenylyl cyclase type III normalizes cilia structure and restores dendrite outgrowth.
Data suggest that while ADCY3 is responsible for a share of the cAMP in osteoclasts, the reduction of cAMP levels in the absence of this gene is insufficient to augment differentiation or effect changes in bone mass in vivo.
We conclude that AC3 in the main olfactory epithelium is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing.
In primary culture and in situ in G93A SOD1 mice there is a large reduction in the proportion of motor neurons bearing a primary cilium.
Maternal behavior was impaired in female mice deficient in adenylyl cyclase 3.
AC3(-/-) mice show no short-term memory for novel objects and fail to exhibit extinction of contextual fear conditioning
GSK3beta inactivation or deletion reduces aquaporin 2 expression by modulating adenylate cyclase activity and cAMP generation, thereby impairing responses to vasopressin in the renal collecting duct
cAMP signals generated by AC3 in the hypothalamus may play a critical role in regulation of body weight
adenylyl cyclase 3 is functional in rodent oocytes and its activity is involved in the control of oocyte meiotic arrest
required for normal spermatid or spermatozoa function and male fertility
point to a major role played by a crucial element of the odorant-induced transduction cascade, adenylyl cyclase 3, in the targeting of olfactory sensory neuron axons towards the brain
There was robust Adcy3 expression in both olfactory sensory neuron cilia and axons during the period of active glomerular formation in neonatal transgenic mice.
Here is formulated an active site model for the mammalian adenylyl cyclase class III, which is used to describe the potential surface along the reaction trajectory for enzyme-catalyzed conversion of ATP to cAMP.
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes.
adenylate cyclase 8 (brain)
, adenylate cyclase type 3
, adenylate cyclase 3-like
, adenylate cyclase 3
, ATP pyrophosphate-lyase 3
, adenylate cyclase type III
, adenylate cyclase, olfactive type
, adenylyl cyclase 3
, adenylyl cyclase, type III
, type III adenylyl cyclase