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Data show that the RAD54 (zeige ATRX Proteine) N-terminal domain (NTD) is responsible for initiation of branch migration (BM) through two coupled, but distinct steps; specific binding to Holliday junctions and RAD54 (zeige ATRX Proteine) oligomerization.
Nap1 (zeige IL8 Proteine) binds to RAD54 (zeige ATRX Proteine).
TAF12 (zeige TAF12 Proteine) and NFYC (zeige NFYC Proteine) are transcription factors that regulate the epigenome, whereas RAD54L (zeige ATRX Proteine) plays a central role in DNA repair
support a model in which RAD54L (zeige ATRX Proteine) and RAD54B (zeige RAD54B Proteine) counteract genome-destabilizing effects of direct binding of RAD51 (zeige RAD51 Proteine) to dsDNA in tumor cells
The RAD54L (zeige ATRX Proteine) polymorphism (2290C/T) can be used as a genetic marker inside the consensus deletion region at 1p32 in human meningiomas.
Shortened telomeres in murine scid (zeige PRKDC Proteine) cells expressing mutant RAD54L (zeige ATRX Proteine) coincide wirth reduction in recombination at telomeres.
hRad54, a Swi2/Snf2 (zeige SMARCA2 Proteine) protein, binds HJ-like structures with high specificity and promotes their bidirectional branch migration in an ATPase-dependent manner
Some immortal cells use the alternative lengthening of telomeres (ALT) pathway to maintain their telomeres instead of telomerase. This is the first genetic evidence that Rad54 is dispensable for the ALT pathway.
RAD54 (zeige ATRX Proteine) is recruited by RAD51 (zeige RAD51 Proteine)-ssDNA filament to the chromatin of the intact chromosome and it remodels that chromatin to facilitate accessibility for strand exchange
analysis of human rad54 (zeige ATRX Proteine) protein interactions with branched DNA molecules
Our study highlights the importance of the cooperation between Rad54 and Mus81 (zeige MUS81 Proteine) for mediating DNA DSB repair and restraining chromosome missegregation.
Rad54 is not required for either transgene isotype switching or transgene hypermutation.
Rad54-mediated homologous recombination is not essential for somatic hypermutation. In addition, the finding that the ablation of RAD51 (zeige RAD51 Proteine) paralogues causes an increase in SHM (zeige CNTNAP1 Proteine) argues against a direct involvement of HR in promoting SHM (zeige CNTNAP1 Proteine).
Rad54 has a role in telomere length maintenance
Rad54 cooperates with DNA Ligase IV (zeige LIG4 Proteine) to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations
Mus81 (zeige MUS81 Proteine)-Eme1- and Rad54-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
These results reveal a differential interaction of the ATM (zeige ATM Proteine)-mediated DNA damage response and Rad54 paralog-mediated homologous recombination depending on the DNA damaging agent that initiates the response.
Rad54 structure suggests that SWI2/SNF2 (zeige SMARCA4 Proteine) proteins use a mechanism analogous to helicases to translocate on dsDNA
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.
DNA repair and recombination protein RAD54-like
, RAD54 homolog
, putative recombination factor GdRad54
, RAD54-like protein
, RAD54-like (S. cerevisiae)