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Human MRE11A Protein expressed in Wheat germ - ABIN1311266
Lee, Padget, Curtis, Cowell, Moiani, Sondka, Morris, Jackson, Cockell, Tainer, Austin: MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. in Biology open 2012
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
meiotic recombination 11 homolog A
, MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
, MRE11 homolog 1
, MRE11 homolog A
, double-strand break repair protein MRE11A
, meiotic recombination 11 homolog 1
, AT-like disease
, DNA recombination and repair protein
, endo/exonuclease Mre11
, meiotic recombination 11-like protein