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Cow (Bovine) Polyclonal SLC7A1 Primary Antibody für WB - ABIN2781583
Kaneko, Okuda-Ashitaka, Ando, Nishimura, Igarashi, Maeda, Furuta, Suzuki, Matsumura, Ito: Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells. in American journal of physiology. Cell physiology 2007
Human Polyclonal SLC7A1 Primary Antibody für IHC, IHC (p) - ABIN4288211
Li, Wu, Shah, Chen, Wangpaichitr, Kuo, Feun, Han, Suarez, Prince, Savaraj: Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation. in Molecular oncology 1970
L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.
Estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK. Progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation.
The rs41318021 polymorphism in the SLC7A1 gene was not associated with essential hypertension in 50-year-old subjects.
Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue.
CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution.
mRNA levels for high-affinity CAT-1, expressed as a percentage of the wild-type value, are increased by an average 12% and 32% in mdx and transgenic mdx:utr mice respectively.
The data demonstrates that CAT1 significantly (but most likely not exclusively) contributes to the cellular uptake of asymmetric dimethylarginine.
In hypoxic human pulmonary microvascular endothelial cells, overexpression of CAT-1 resulted in significantly greater L-arginine transport and NO production
In acute congestive heart failure acute renal impairment function and the modulation of metabolism and extracellular transport by the DDAH-1/CAT-1 system determine high ADMA and SDMA levels after therapy for acute congestive heart failure.
Insulin increased hCATs-L-arginine transport, maximal transport capacity, and hCAT-1 expression. Sp1 nuclear protein abundance and binding to DNA, and SLC7A1 promoter activity was increased by insulin.
Data show that the CAT-1 isoform plays a role in arginine uptake.
PKC activation also resulted in ubiquitination of CAT-1
analysis of the genomic organization
Stable polarized expression of hCAT-1 in an epithelial cell line.
Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells.
Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression
Glomerular arginine uptake is elevated through modulation of CAT-1 expression, thus, contributing to the pathogenesis of hyperfiltration. Increased nitric oxide formation may play a role in this process.
protein kinase C(PKC) did not phosphorylate human cationic amino acid transporter hCAT-1 directly as evidenced by in vivo phosphorylation experiments and mutational analysis, indicating an indirect action of PKC on hCAT-1
The CAT-1 is thought to supply substrate to endothelial NOS by virtue of its co-localisation with this enzyme.
The present study identifies a key functionally active polymorphism in the 3'UTR of SLC7A1 [which] may account for the apparent link between altered endothelial function, L-arginine, and nitric oxide metabolism and predisposition to essential hypertension
A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
Endothelial CAT-1 overexpression can counter the ability of oxidative stress.
L-argine transporters CAT-1 and CAT-2A expression and function are significantly increased in Duchenne muscular dystrophy mice.
findings suggest a novel role for GRB2 in ecotropic MLV entry and infection by facilitating mCAT-1 trafficking
data suggest that direct interaction of eNOS with CAT-1 enhances NO release by a mechanism not involving arginine transport.
In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.
Ecotropic MuLV and its env protein downregulate the MuLV receptor (CAT1) via interaction of CAT1 with clathrin adaptor protein complexes.
Ecotropic mouse gammaretroviruses entry and virus-induced syncytium formation using the CAT-1 receptor are mediated by a small number of critical amino acid residues in receptor and virus Env.
analysis of how a bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha)
High performance liquid chromatography (HPLC) analyses showed that Transmissible gastroenteritis virus infection leads to reduced arginine uptake at 48 hours post-infection (hpi). Expression of cationic amino acid transporter 1 (CAT-1) was attenuated as well.
Arginine supplementation enhances small intestinal expression of SLC7A7 and SLC7A1.
Changes in the expression of b(0,+) and CAT-1 in pigs fed on amino acid supplemented versus high proteins diets.
Data show that in minipigs, increased weight and cholesterol resulting from a high-cholesterol diet are correlated with a decrease in the expression of miRNA-122, and that gene expression levels of CAT1 do not differ between groups.
Radiation hybrid mapping data indicate that the porcine SLC7A1 maps to the distal end of the short arm of pig chromosome 11
Lipopolysaccharide/tumor necrosis factor-alpha treatment increased the expression of iNOS, arginase II, CAT-1, and CAT-2 mRNA.
Real time-PCR results indicated that SLC15A1, SLC7A1 and SLC1A1 genes throughout the rabbits' entire development and were expressed in all tested rabbit digestive sites, including the stomach, duodenum, jejunum, ileum, colon and cecum.
acts as a cationic amino acid transporter and as an ecotropic retrovirus receptor\; plays a role in the Na+-independent y+ cationic amino acid transport system
, amino acid transporter, cationic 1
, ecotropic retroviral leukemia receptor homolog
, ecotropic retroviral receptor
, ecotropic retrovirus receptor homolog
, high affinity cationic amino acid transporter 1
, solute carrier family 7 member 1
, system Y+ basic amino acid transporter
, cationic amino acid transporter 1
, ecotropic retroviral leukemia receptor
, ecotropic retrovirus receptor
, Solute carrier family 7 member A1 (amino acid transporter cationic 1)
, cationic amino acid transporter, y+ system
, cationinc amino acid transporter 1
, solute carrier family 7, member 1
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
, cationic amino acid transporter-1
, high affinity cationic amino acid transporter 1-like