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anti-Human SLC1A5 Antikörper:
anti-Mouse (Murine) SLC1A5 Antikörper:
anti-Rat (Rattus) SLC1A5 Antikörper:
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Cow (Bovine) Polyclonal SLC1A5 Primary Antibody für IHC, WB - ABIN2775316
Bungard, McGivan: Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers. in Archives of biochemistry and biophysics 2005
Show all 4 Pubmed References
Human Polyclonal SLC1A5 Primary Antibody für IF (p), IHC (p) - ABIN669081
Huang, Zhao, Zhao, Wu, Jiang, Ma, Zhang: Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer. in International journal of clinical and experimental pathology 2014
Human Polyclonal SLC1A5 Primary Antibody für ICC, IF - ABIN4354074
Sun, Yu, Wu, Chen, Shi, Zheng, Xu: GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma. in PLoS ONE 2016
ASCT2 was significantly overexpressed in the gastric cancer (GC) samples compared with adjacent non-cancerous gastric mucosa, in contrast, a significantly higher level of glutamine synthetase (GS (zeige GLUL Antikörper)) expression was observed in normal tissues than in GC samples compared with adjacent non-cancerous gastric mucosa.
These results indicated that ASCT2 (SLC1A5) could be a novel therapeutic target against KRAS-mutant colorectal cancer.
AR signaling promoted glutamine (zeige GFPT1 Antikörper) metabolism by increasing the expression of the glutamine (zeige GFPT1 Antikörper) transporters SLC1A4 (zeige SLC1A4 Antikörper) and SLC1A5, genes commonly overexpressed in prostate cancer. Correspondingly, gene expression signatures of AR activity correlated with SLC1A4 (zeige SLC1A4 Antikörper) and SLC1A5 mRNA levels in clinical cohorts.
Results provide evidence that ASCT2 enhances glutamine (zeige GFPT1 Antikörper) uptake in glycolipid-enriched microdomain/rafts in GD2(+) small-cell lung cancer cells, leading to the enhancement of cell proliferation and migration.
High ASCT2 expression is associated with head and neck squamous cell carcinoma.
this study shows that IL-2 (zeige IL2 Antikörper)-induced expression of SLC1A5 is a prerequisite for NKG2D (zeige KLRK1 Antikörper)-mediated activation of NK cells
we found that PPARdelta (zeige PPARD Antikörper) directly regulated neutral amino acid transporter (zeige SLC6A19 Antikörper) SLC1 (zeige MCHR1 Antikörper)-A5 (solute carrier family 1 member 5) and glucose transporter-1 (Glut1 (zeige SLC2A1 Antikörper)) gene transcription, leading to uptake of glucose and amino acid, activation of mTOR (zeige FRAP1 Antikörper) signaling, and tumor progression. In contrast, silence of PPARdelta (zeige PPARD Antikörper) or its antagonist inhibited this event.
Data suggest that both heterogeneous nuclear ribonucleoprotein (zeige PCBP2 Antikörper) type M (HNRPM (zeige HNRNPM Antikörper)) and solute carrier (zeige SERTAD2 Antikörper) 1A5 (SLC1A5) have role in the pathogenesis of ovarian cancer.
Both stable and inducible shRNA-mediated ASCT2 knockdown confirmed that inhibiting ASCT2 function was sufficient to prevent cellular proliferation and induce rapid cell death in TN basal-like breast cancer cells, but not in luminal cells.
ASCT2 is an EGFR (zeige EGFR Antikörper)-associated protein that can be co-targeted by cetuximab, leading to sensitization of cetuximab-treated cells to ROS (zeige ROS1 Antikörper)-induced apoptosis.
Data show that SERT (zeige SLC6A4 Antikörper) associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier (zeige SERTAD2 Antikörper) 1 family co-expressed with SERT (zeige SLC6A4 Antikörper) in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane.
These findings highlight a mechanism of T cell activation involving ASCT2-dependent integration of the T cell receptor signal and a metabolic signaling pathway.
used as receptor by HERV-W Env (zeige ERVW-1 Antikörper) glycoproteins when their sites for N-linked glycosylation are eliminated by mutagenesis
results strongly suggest that combinations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-terminal region of extracellular loop 2 (ECL2) control retroviral utilization of both the ASCT1 (zeige SLC1A4 Antikörper) and ASCT2 receptors
amino acid transporter B(0)/ASC transporter 2 expression is necessary for SK-Hep cell growth
ASCT1 (zeige SLC1A4 Antikörper) and ASCT2 mRNA were expressed in cultured blood-brain barrier[BBB (zeige ALMS1 Antikörper)] cells; expression of ASCT2 mRNA was 6.7-fold greater. ASCT2 is localized at the abluminal side of the mouse BBB (zeige ALMS1 Antikörper), suggesting a key role in l-isomer-selective Asp (zeige C3 Antikörper) transport at the BBB (zeige ALMS1 Antikörper)
data support ASCT2 function in both neuron and astrocyte cultures and identify a discrepancy between observed asc-1 (zeige SLC7A10 Antikörper) immunoreactivity and lack of functional asc-1 (zeige SLC7A10 Antikörper) activity in neuron cultures, elucidating processes that govern D-serine regulation
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001
neutral amino acid transporter B(0)
, RD114 virus receptor
, RD114/simian type D retrovirus receptor
, baboon M7 virus receptor
, neutral amino acid transporter B
, sodium-dependent neutral amino acid transporter type 2
, solute carrier family 1 member 5
, alanine/serine/cysteine/threonine transporter 2
, neutral amino acid transporter B0
, ASC-like Na(+)-dependent neutral amino acid transporter ASCT2
, insulin-activated amino acid transporter
, solute carrier family 1, member 7
, CAZ-associated structural protein
, H4-system ASC-like transporter
, sodium-dependent neutral amino acid transporter ASCT2