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Human Polyclonal FOLR2 Primary Antibody für IHC - ABIN966159
Page, Owen, Price, Elwood: Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. in Journal of molecular biology 1993
Show all 3 Pubmed References
Human Polyclonal FOLR2 Primary Antibody für FACS, IHC (p) - ABIN651222
Puligujja, McMillan, Kendrick, Li, Balkundi, Smith, Veerubhotla, Edagwa, Kabanov, Bronich, Gendelman, Liu: Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections. in Nanomedicine : nanotechnology, biology, and medicine 2013
Silencing of the expression of the FOLR2 gene in NCI-H1650 cells reduced cell viability, increased cell apoptosis, and arrested cells in the G1 phase of the cell cycle, decreased the expression of cyclin D1, upregulated expression of cell cycle inhibitors, p21 and p27, upregulated the expression of Bax/Bcl-2, and inhibited phosphorylation of AKT, mTOR, and S6K1.
We identified eight novel variants in SLC19A1 and twelve novel variants in FOLR1, FOLR2, and FOLR3. Pathogenic variants include c.1265delG in SLC19A1 resulting in an early stop codon, four large insertion deletion variants in FOLR3, and a stop_gain variant in FOLR3
Folate receptor beta as a novel CD11b/CD18 regulator for trafficking and homing of a subset of macrophages on collagen.
we confirmed the similarities between epithelial ovarian cancer and fallopian tube, normal and adenocarcinoma using FOLR1, FOLR2, CD68 and CD11b markers
FR-beta expression was low or absent in the majority of ovarian, breast and colorectal tumor samples.
FR-beta is uniquely expressed on this proinflammatory subpopulation offers a new strategy to suppress migration of inflammatory monocytes into sites of inflammation.
The FRalpha gene was expressed in all parathyroid cells analyzed, and the FRbeta gene was expressed by most.
High FOLR2 mRNA expression is associated with uraemic patients on hemodialysis.
severe pre-eclampsia is associated with decreased placental expression of FR-beta and a reduction in the number of fetal macrophages (Hofbauer cells)
Expression of folate receptor-beta on activated macrophages holds a promising potential for early diagnosis of atherosclerosis. (Review)
High Folate Receptor beta expressing tumor-associated macrophages are associated with pancreatic cancer.
Functional FR-beta present on osteoarthritis synovial macrophages provides a potential tool for the diagnosis and treatment of this disease.
The rare alleles of specific single nucleotide polymorphisms within the FOLR1, FOLR2, and FOLR3 genes were statistically significant for association with meningomyelocele.
study describes that functional FRbeta is specifically expressed by M-CSF-polarized (M2) macrophages as well as by ex vivo isolated tumor-associated macrophages, and that tumors induce its expression in an M-CSF-dependent manner
FR-beta gene is a target for multiple coordinate actions of nuclear receptors for ATRA directly and indirectly acting on a transcriptional complex containing activating Sp1/ets and inhibitory AP-1 proteins.
The characteristics of folate transport in oocytes are consistent with folate receptor-mediated endocytosis, possibly by the FOLR2 isoform.
FRbeta expression was markedly increased in lung macrophages at 48 hours after intratracheal LPS.
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cell embryos and blastocysts.
Folbp2 null cells display increased sensitivity to arsenic exposure
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
folate receptor 2 (fetal)
, folate receptor beta
, folate receptor, beta
, folate receptor, fetal/placental
, folate-binding protein, fetal/placental
, placental folate-binding protein
, folate binding protein 2
, folate-binding protein 2