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Human Monoclonal FOLR1 Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899886
Kelemen, Brenton, Parkinson, C Whitaker, Piskorz, Csizmadi, Robson: Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women. in PLoS ONE 2014
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Human Polyclonal FOLR1 Primary Antibody für CyTOF, FACS - ABIN4899887
Rudman, Josephs, Cambrook, Karagiannis, Gilbert, Dodev, Hunt, Koers, Montes, Taams, Canevari, Figini, Blower, Beavil, Nicodemus, Corrigan, Kaye, Nestle, Gould, Spicer, Karagiannis et al.: Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I ... in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011
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Cow (Bovine) Monoclonal FOLR1 Primary Antibody für ELISA - ABIN253769
Jones, Nixon: Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein. in The Journal of nutrition 2002
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Cow (Bovine) Polyclonal FOLR1 Primary Antibody für IHC, WB - ABIN2776804
Iwakiri, Sonobe, Nagai, Hirata, Wada, Miyahara: Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers. in Annals of surgical oncology 2008
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Human Monoclonal FOLR1 Primary Antibody für FACS - ABIN4896856
Ando, Nagata, Nihira, Suzuki, Kanda, Adachi, Kubota, Kameyama, Nakano, Ando, Yamano, Ishii, Nakai, Nakamura: Potent Therapeutic Activity Against Peritoneal Dissemination and Malignant Ascites by the Novel Anti-Folate Receptor Alpha Antibody KHK2805. in Translational oncology 2017
Several experimental studies in mice and human epidemiological and genetics studies have suggested that FOLR1 abnormalities are involved in a portion of human neural tube defects (NTD), although the solo defect of FOLR1 did not cause NTD. (Review)
that FOLR1 is highly expressed in ovarian cancer but is reduced following multidrug resistance. FOLR1 may be a useful biomarker for ovarian cancer, and it may be useful as a therapeutic application to improve sensitivity to cisplatin treatment
mTORC1 or mTORC2 (zeige CRTC2 Antikörper) silencing markedly decreases the plasma membrane expression of FR-alpha and RFC (zeige RFC1 Antikörper) transporter isoforms without affecting global protein expression
High Folate Receptor Alpha Expression Is Associated With Increased Risk of Recurrence in Triple-negative Breast Cancer.
The expression of folate receptor 1 (FOLR1) was significantly higher and occurred with higher frequency in metastatic lymph node samples from patients with advanced lung cancer.
We identified eight novel variants in SLC19A1 (zeige SLC19A1 Antikörper) and twelve novel variants in FOLR1, FOLR2 (zeige FOLR2 Antikörper), and FOLR3 (zeige FOLR3 Antikörper). Pathogenic variants include c.1265delG in SLC19A1 (zeige SLC19A1 Antikörper) resulting in an early stop codon, four large insertion deletion variants in FOLR3 (zeige FOLR3 Antikörper), and a stop_gain variant in FOLR3 (zeige FOLR3 Antikörper)
In this study, folate receptor alpha (FRa (zeige FOSL1 Antikörper))-targeted nano-liposomes (FLP (zeige HPD Antikörper)) were designed to enhance the anti-tumor effect by targeting delivery of exogenous PEDF (zeige SERPINF1 Antikörper) gene to cervical cancer cells..These results clearly showed that FLP (zeige HPD Antikörper) were desired carriers for PEDF (zeige SERPINF1 Antikörper) gene and FLP (zeige HPD Antikörper)/PEDF (zeige SERPINF1 Antikörper) might represent a potential novel strategy for gene therapy of cervical cancer.
Data show that higher folate receptor alpha (FRalpha) expression is predictive of a favorable prognosis in pancreatic ductal adenocarcinoma (PDAC) and FRalpha may represent a promising target for treatments.
our results demonstrate the substantial therapeutic potential of novel 6-substituted pyrrolo[2,3-d]pyrimidine antifolates with dual targeting of PCFT (zeige SLC46A1 Antikörper) and FRalpha toward Epithelial ovarian cancer that express a range of FRalpha, along with PCFT (zeige SLC46A1 Antikörper), as well as cisplatin resistance
Low expression level of FOLR1 is associated with neuroendocrine lung tumors.
These findings support a model in which the folate receptor (zeige FOLR3 Antikörper) interacts with cell adhesion molecules, thus regulating the apical cell membrane remodeling and cytoskeletal dynamics necessary for neural plate folding.
This study presented the disintegration of folate from bovine FOLR1 during high temperature processing.
FOLR1 is a key regulatory point of folate metabolism for milk protein (zeige CSN2 Antikörper) synthesis within mammary epithelial cells.
Results show that the gene zgc:165502 is an orthologue of human Folate Receptor 1 located on chromosome 15 and is expressed globally during cleavage and gastrulation.
Midbrain dopamine neural progenitors and nascent dopamine neurons specifically express Folr1.
Folate receptor alpha upregulates Oct4 (zeige POU5F1 Antikörper), Sox2 (zeige SOX2 Antikörper) and Klf4 (zeige KLF4 Antikörper) and downregulates miR (zeige MLXIP Antikörper)-138 and miR (zeige MLXIP Antikörper)-let-7 in cranial neural crest cells.
Folate receptor (zeige FOLR3 Antikörper) expression on murine and human adipose tissue macrophages
Quantitative RT-PCR showed that Slc19a1 (zeige SLC19A1 Antikörper) mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward.
under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered.
Nesting of T helper cell epitopes results in recruitment of latent pools of naive high-affinity/avidity folate receptor (zeige FOLR3 Antikörper) (FR)alpha-specific T cells, which have the ability to home to tumors expressing FRalpha and to reduce tumor burden.
Fbp1 (zeige FBP2 Antikörper) has a role in anterior neural tube closure
Abnormal heart looping was observed during early development of Folr1(-/-) embryos partially rescued by maternal folinic acid supplementation.
folate receptor (zeige FOLR3 Antikörper) type beta is induced in a bone marrow engraftment model of acute myelogenous leukemia
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
, KB cells FBP
, adult folate-binding protein
, folate binding protein
, folate receptor alpha
, folate receptor, adult
, ovarian tumor-associated antigen MOv18
, erythroid-specific folate receptor
, membrane-bound folate binding protein
, folate receptor 1 (adult)
, Folate receptor alpha
, folate binding protein 1
, folate-binding protein 1