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In RCC tissues and renal carcinoma cells, miR-28-5p is expressed at a low level and RAP1B is expressed at a high level. miR-28-5p inhibits the tumorigenesis of RCC by directly downregulating RAP1B and influencing the activation of two MAP kinases in the MAPK signaling pathway, p38 and Erk1/2.
describe the methods for expression and purification of the plexin cytoplasmic region in E. coli, and characterization of its GAP activity using a photometric assay. We also provide a protocol for measuring GAP activity of single-chain constructs with Rap (zeige LRPAP1 Antikörper) covalently linked to the plexin cytoplasmic region
Unlike Rap1B, phosphorylation in the polybasic region of Rap1A (zeige RAP1A Antikörper) does not detectably inhibit its prenylation or its binding to SmgGDS (zeige RAP1GDS1 Antikörper)-607.
Data show that RAP1B expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B interacted with DVL2 (zeige DVL2 Antikörper) and activated Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
The protein expression of RAP1B and HIF-1 alpha (zeige HIF1A Antikörper) contributed to gastric cancer malignant behavior and poor prognosis.
Cholera toxin and beta-adrenergic receptor activation phosphorylate Rap1B and inhibit its prenylation and membrane localization.
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Adenosine signaling reduces prenylation and plasma membrane localization of Rap1B, resulting in enhanced tumor cell scattering and invasiveness.
High concentrations of extracellular adenosine in the tumor microenvironment can chronically activate A2B (zeige ADORA2B Antikörper) receptors to suppress Rap1B prenylation and signaling at the cell membrane, resulting in reduced cell-cell contact and promoting cell scattering.
TMZ as a standard chemotherapeutic agent for GBM inhibits the Rap1B expression and actin cytoskeleton remodeling to exert its cell killing by upregulating miR (zeige MLXIP Antikörper)-181a/b/c/d subunits
RAP1 (zeige TERF2IP Antikörper)-mediated MEK (zeige MAP2K1 Antikörper)/ERK (zeige MAPK1 Antikörper) pathway defects in Kabuki syndrome.
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature
findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase (zeige RACGAP1 Antikörper) and an associated local synaptic protein translation network in this process.
Rap1 deficiency impaired T-cell homeostasis.
Rap1b deficiency promoted the transcellular route of diapedesis through endothelial cell. Increased transcellular migration of Rap1b-deficient neutrophils in vitro was selectively mediated by enhanced PI3K-Akt (zeige AKT1 Antikörper) activation and invadopodia-like protrusions.
Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone.
Talin1 and Rap1 are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss.
two different activation mechanisms of Rap1b as well as novel functions of Rap1b in platelet secretion and in integrin alpha(IIb)beta(3) outside-in signaling.
Rap1b-dependent VEGF (zeige VEGFA Antikörper)-VEGFR2 (zeige KDR Antikörper) activation is in part mediated via integrin alpha(v (zeige ITGAV Antikörper))beta(3).
Upon activation, Rap1b colocalized with the scaffolding protein IQGAP1 (zeige IQGAP1 Antikörper).
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9.
GTP-binding protein smg p21B
, RAS-related protein RAP1B
, Ras family small GTP binding protein RAP1B
, ras-related protein Rap-1b
, small GTP binding protein
, RAS related protein 1b
, RAP1B, member of RAS oncogene family
, ras-related protein Rap-1A
, Ras-related protein Rap-1b
, ras-related protein Rap-1b-like
, Ras-related protein Rap-1b-like protein
, ras-related protein rab-1B-like protein