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In embryos defective for S1pr2 (zeige S1PR2 Proteine)/Galpha13 signaling, endocardial precursors failed to migrate towards the midline, and the presumptive endocardium surrounded the bilaterally-located myocardial cells rather than being encompassed by them.
Gpr56 (zeige GPR56 Proteine) regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA (zeige RHOA Proteine)
S1pr2 (zeige S1PR2 Proteine)/Galpha13 signaling controls myocardial migration by regulating endoderm convergence.
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13) and rhoA (zeige RHOA Proteine) GTP-binding protein (RhoA (zeige RHOA Proteine)) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL).
Data (including data from studies using transgenic mice) suggest that R7BP (zeige RGS7BP Proteine)-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP (zeige RGS7BP Proteine) = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit (zeige POLG Proteine) 13)
Upregulation of GNA13 expression increased the proliferation and tumorigenicity of gastric cancer.
Knockdown DDR1 (zeige DDR1 Proteine) reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.
RGS22 acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.
Galpha13 Switch Region 2 Binds to the Talin Head Domain and Activates alphaIIbbeta3 Integrin in Human Platelets
GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR (zeige MLXIP Proteine)-31.
Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1 (zeige F2R Proteine)) at extracellular loop 2 (ECL2) controls G12 (zeige TCF3 Proteine)/13 versus Gq G-proteins coupling specificity in response to thrombin (zeige F2 Proteine) stimulation.
Our findings highlight the important role of miR (zeige MLXIP Proteine)-29c in regulating CRC (zeige CALR Proteine) EMT (zeige ITK Proteine) via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A (zeige PTP4A2 Proteine) and provide new insights into the metastatic basis of colorectal cancer
These results place Blk (zeige BLK Proteine) upstream of the p190RhoGAP (zeige GRLF1 Proteine)-RhoA (zeige RHOA Proteine) pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12 (zeige CXCL12 Proteine)-triggered invasion.
results define Galpha13 as a switch regulator of myofiber reprogramming, implying that modulations of Galpha13 and its downstream effectors in skeletal muscle are a potential therapeutic approach to treating metabolic diseases.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG (zeige ARHGEF12 Proteine) interaction compared to the Galpha13 activation in the absence of LARG (zeige ARHGEF12 Proteine).
GNA13 loss is associated with GC B (zeige NPR2 Proteine)-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development.
Selective inhibition of G12 (zeige TCF3 Proteine)/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma
Direct Galpha13 binding to ITGB3 (zeige ITGB3 Proteine) cytoplasmic domain regulates integrin outside-in signaling and thrombus formation in platelets.
Galpha (zeige SUCLG1 Proteine) 13 is activated in sensory neurons mediated by lysophosphatidylinositol.
Galpha13 binding to VE-cadherin (zeige CDH5 Proteine) mediates VE-cadherin (zeige CDH5 Proteine) internalization and endothelial barrier disruption and inflammation.
Data indicate that Pyk2 (zeige PTK2B Proteine) is a common signaling effector downstream of both G12 (zeige TCF3 Proteine)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
guanine nucleotide binding protein, alpha 13
, guanine nucleotide-binding protein subunit alpha-13
, Galpha 13a
, Galpha 13b
, G-protein alpha 13b
, guanine nucleotide binding protein (G protein), alpha 13
, guanine nucleotide-binding protein subunit alpha-13-like
, G-protein subunit alpha-13
, g alpha-13