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Cutaneous Malignant Melanoma/dysplastic Nevus Antikörper (C-Term)

CMM Reaktivität: Human FACS, WB, IHC (p) Wirt: Kaninchen Polyclonal RB18645 unconjugated
Produktnummer ABIN6242125
  • Target
    Cutaneous Malignant Melanoma/dysplastic Nevus (CMM)
    Bindungsspezifität
    AA 72-101, C-Term
    Reaktivität
    Human
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MLM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the C-terminal region of human MLM.
    Klon
    RB18645
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    Cutaneous Malignant Melanoma/dysplastic Nevus (CMM)
    Andere Bezeichnung
    MLM
    Synonyme
    CMM1 antikoerper, DNS antikoerper, FAMMM antikoerper, MLM antikoerper, cutaneous malignant melanoma/dysplastic nevus antikoerper, CMM antikoerper
    Hintergrund
    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
    Molekulargewicht
    13903
    NCBI Accession
    NP_478102
    UniProt
    Q8N726
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