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Crystallin, alpha B Proteine

(Crystallin, alpha B (CRYAB))
Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases\; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].

26 Treffer

CRYAB Spezies: Huhn Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1458765
 
CRYAB Spezies: Schaf Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1632520
 
CRYAB Spezies: Orang-Utan Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1635840
 
CRYAB Spezies: Kaninchen Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1473214
 
CRYAB Spezies: Syrischer Goldhamster Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1611360
 
CRYAB Spezies: Dogfish (Squalus) Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1611346
 
  • Typ Protein
    • Protein
  • Anwendung
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Standard (STD)
  • Reaktivität
    • Human
    • Mouse
    • Blackbird
    • Bullfrog
    • Chicken
    • Columba livia
    • Cow
    • Dogfish (Squalus)
    • Duck
    • Golden Syrian Hamster
    • Orang-Utan
    • Rabbit
    • Rat
    • Sheep
    • Trachemys scripta
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • Yeast
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Wheat germ
  • Bindungsspezifität
    • AA 1-175
    • AA 1-52
    • AA 1-174
    • AA 1-173
    • AA 1-177
    • full length
  • Konjugat
    • His tag
    • Unkonjugiert
    • GST tag
    • His-SUMO Tag
    • Myc-DYKDDDDK Tag
    • Strep Tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Grade
    • custom-made
  • Hersteller
    • CUSABIO
    • antibodies-online
    • OriGene
    • Signalway

Aktuelle Publikationen für unsere Crystallin, alpha B Proteine

Anders, Liu, Mann, Teister, Lauzi, Thanos, Grus, Pfeiffer, Prokosch: "The Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model." in: International journal of molecular sciences, Vol. 18, Issue 11, (2018) (PubMed).

Aliase für Crystallin, alpha B Proteine

crystallin alpha B (CRYAB) Proteine
crystallin, alpha B (Cryab) Proteine
hypothetical protein (ZK1128.7) Proteine
crystallin alpha B (Cryab) Proteine
crystallin, alpha B, a (cryaba) Proteine
crystallin, alpha B, b (cryabb) Proteine
AACRYA Proteine
CMD1II Proteine
Crya-2 Proteine
CRYA2 Proteine
Crya2 Proteine
CRYAB Proteine
cryab Proteine
cryab2 Proteine
CTPP2 Proteine
CTRCT16 Proteine
HSPB5 Proteine
HspB5 Proteine
MFM2 Proteine
wu:fe37f08 Proteine
zgc:91937 Proteine
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