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Active DNA demethylation by DEMETER requires SSRP1 function through a distinctly different process from direct DNA methylation (zeige HELLS Proteine) control.
SPT16 and SSRP1 are critically involved in the regulation of leaf growth, flowering time and seed production, and interact with HUB1/2.
results show that FACT, a heterodimer of dSPT16 (zeige SUPT16H Proteine) and dSSRP1, associates with GAGA factor through its dSSRP1 subunit & facilitates chromatin remodeling; interactions between GAGA factor and spt16 (zeige SUPT16H Proteine) implicate the GAGA factor-FACT complex in Hox (zeige MSH2 Proteine) gene expression
Results report the solution structure of the HMG (zeige HMGCR Proteine)-box domain in Drosophila SSRP1.
rapid chromatin transactions during early embryogenesis through the dephosphorylation of some sites in the maternally transmitted dSSRP1
Ssrp1a is essential for proliferation and differentiation during eye and liver organogenesis.
These data uncover a previously unknown role for SSRP1 in promoting the activation of the Wnt (zeige WNT2 Proteine) signaling pathway activity during cellular differentiation.
The association of LEDGF (zeige PSIP1 Proteine) proteins with the FACT complex and give further support to a role of SSRP1 in HIV-1 infection.
Results show that SSRP1 upregulation contributed to hepatocellular carcinoma development and the tumor-suppressive miR (zeige MLXIP Proteine)-497 served as its negative regulator.
FACT chaperone stabilizes the soluble CENP-T (zeige CENPT Proteine)/-W complex in the cell and promotes dynamics of exchange, enabling CENP-T (zeige CENPT Proteine)/-W deposition at centromeres.
SSRP1/Ets-1 (zeige ETS1 Proteine)/Pim-3 (zeige PIM3 Proteine) signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel.
Our studies facilitate the understanding of SSRP1 and provide insights into the molecular mechanisms of interaction with DNA and histones of the FACT complex.
AID accesses the H2B N-terminal basic region exposed by partial unwrapping of the nucleosomal DNA, thereby triggering the invasion of FACT into the nucleosome
FACT is required for TOP1 (zeige TOP1 Proteine) binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage.
FACT, NF-kappaB (zeige NFKB1 Proteine), and cell-cycle progression are inhibited by quinacrine, which overcomes resistance to erlotinib in non-small cell lung cancer
EEF1A1 (zeige EEF1A1 Proteine), SSRP1, and XRCC6 (zeige XRCC6 Proteine) are novel interacting partners of the mineralocorticoid receptor (zeige NR3C2 Proteine)
Ssrp1 appears to encode nonredundant and p53 (zeige TP53 Proteine)-independent functions that are essential for cell viability
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
FACT complex subunit Ssrp1
, FACT complex subunit SSRP1
, chorion factor
, structure specific recognition protein
, structure-specific recognition protein
, Ssrp1 protein
, structure specific recognition protein 1
, structure-specific recognition protein 1
, facilitates chromatin transcription complex subunit SSRP1
, FACT complex subunit SSRP1-like
, recombination signal sequence recognition protein 1
, FACT 80 kDa subunit
, chromatin-specific transcription elongation factor 80 kDa subunit
, cisplatin-DNA SSRP
, facilitates chromatin remodeling 80 kDa subunit
, facilitates chromatin transcription complex 80 kDa subunit
, high mobility group box
, DNA unwinding factor 87 kDa subunit
, facilitates chromatin transcription complex subunit ssrp1
, delta-crystallin enhancer binding protein
, high mobility group 1 protein
, Structure-specific recognition protein 1