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anti-Human PRMT5 Antikörper:
anti-Mouse (Murine) PRMT5 Antikörper:
anti-Rat (Rattus) PRMT5 Antikörper:
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Dog (Canine) Monoclonal PRMT5 Primary Antibody für IF, WB - ABIN968582
Gilbreth, Yang, Bartholomeusz, Pimental, Kansra, Gadiraju, Marcus: Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 3 Pubmed References
Dog (Canine) Monoclonal PRMT5 Primary Antibody für IF, WB - ABIN968581
Krapivinsky, Pu, Wickman, Krapivinsky, Clapham: pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. in The Journal of biological chemistry 1998
Show all 3 Pubmed References
Human Polyclonal PRMT5 Primary Antibody für WB - ABIN4347350
Guo, Zheng, Xu, Dai, Zhou, Pascua, Chen, Shen: Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. in Nature chemical biology 2010
Human Polyclonal PRMT5 Primary Antibody für IHC (p), IHC - ABIN258206
Pak, Lee, Roh: High nuclear expression of protein arginine methyltransferase-5 is a potentially useful marker to estimate submucosal invasion in endoscopically resected early colorectal carcinoma. in Pathology international 2015
Human Polyclonal PRMT5 Primary Antibody für ELISA, WB - ABIN451788
Zhao, Rank, Tan, Li, Moritz, Simpson, Cerruti, Curtis, Patel, Allis, Cunningham, Jane: PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. in Nature structural & molecular biology 2009
These results could be helpful in discovering new potent and specific inhibitors of PRMT5, as well as in designing mutant residue assay to modulate the catalytic activity of PRMT5.
PRMT1 (zeige PRMT1 Antikörper) inhibition prevents gastric cancer progression by downregulating eIF4E (zeige EIF4E Antikörper) and targeting type II PRMT5.
Data indicate that ZNF326 (zeige ZNF326 Antikörper) is an interaction partner and substrate of the PRMT5/WDR77 (zeige WDR77 Antikörper) complex.
ERG (zeige ERG Antikörper) signaling in prostate cancer is driven through PRMT5-dependent methylation of the androgen receptor (zeige AR Antikörper).
SFN (zeige SFN Antikörper) treatment of tumors results in reduced MEP50 (zeige WDR77 Antikörper) level and H4R3me2s formation, confirming that that SFN (zeige SFN Antikörper) impacts this complex in vivo. These studies suggest that the PRMT5/MEP50 (zeige WDR77 Antikörper) is required for tumor growth and that reduced expression of this complex is a part of the mechanism of SFN (zeige SFN Antikörper) suppression of tumor formation.
High nuclear PRMT5 expression is associated with oropharyngeal squamous cell carcinoma.
High PRMT5 expression is associated with prostate cancer.
Results provide evidence that PRMT5 and p44 regulate gene expression of growth and anti-growth factors to promote lung tumorigenesis.
PRMT5 regulates internal ribosome entry site-dependent translation via methylation of hnRNP A1 (zeige HNRNPA1 Antikörper).
PRMT5 knockdown reduces growth, survival, and colony formation of chronic myelogenous leukemia CD34 (zeige CD34 Antikörper)+ cells.
PRMT5 is an osteoclastogenesis activator and PRMT5 inhibition suppresses osteoclast differentiation via downregulation of CXCL10 (zeige CXCL10 Antikörper) and RSAD2 (zeige RSAD2 Antikörper).
PRMT5 maintains progenitor cells through its regulation of Bmp4 (zeige BMP4 Antikörper); adult and embryonic stem cells also require PRMT5 for maintaining pluripotency, suggesting that similar mechanisms might regulate lineage-restricted progenitor cells during organogenesis.
Menin and PRMT5 suppress GLP1R (zeige GLP1R Antikörper) transcript levels and PKA-mediated phosphorylation of FOXO1 (zeige FOXO1 Antikörper) and CREB (zeige CREB1 Antikörper).
findings show that PRMT5 is an important modulator of CD4 (zeige CD4 Antikörper)(+) T cell expansion; PRMT5 was transiently upregulated during maximal proliferation of mouse and human memory Th cells; data implicate PRMT5 in the regulation of adaptive memory Th cell responses
Prmt5 facilitates promoter-enhancer looping and gene expression at the PPARgamma2 (zeige PPARG Antikörper) locus, which encodes a critical lineage-determining factor that drives the differentiation of adipose tissue.
Taken together, our data reveal a pathophysiologically relevant role for PRMT5 in MHC II transactivation in macrophages
Prmt5 is required for germ cell survival during spermatogenesis in mice.
Prmt5 controls proliferation of adult muscle stem cells by direct epigenetic silencing of the cell cycle inhibitor (zeige CDKN2A Antikörper) p21 (zeige D4S234E Antikörper).
a combinatorial role of PRMT4/CARM1 (zeige CARM1 Antikörper) and PRMT5 for proper myogenesis in zebrafish
Data indicate that MEP50 (zeige WDR77 Antikörper) WD repeat protein (zeige DCAF7 Antikörper) is essential for methylation of histones H4 and H2A (zeige H2AFX Antikörper) by PRMT5 arginine methyltransferase.
data support a mechanism in which MEP50 (zeige WDR77 Antikörper) binds substrate and stimulates PRMT5 activity modulated by substrate post-translational modifications
Protein arginine methyltransferase Prmt5-Mep50 (zeige WDR77 Antikörper) methylates histones H2A (zeige H2AFX Antikörper) and H4 and the histone chaperone nucleoplasmin (zeige NPM1 Antikörper) in Xenopus laevis eggs
The results suggested that medaka Mep50 (zeige WDR77 Antikörper) could be a partner of Prmt5 and might play major roles in a variety of tissues in medaka.
It show the morphological and functional phenotypes of single or double null alleles of prmt-5 in Caenorhabditis elegans. The prmt-1 (zeige PRMT1 Antikörper);prmt-5 double mutants are viable, and exhibit short body length and small brood size compared to N2 and each of the single mutants.
The PRMT-5 catalyzes the symmetric dimethylation of substrates containing monomethylarginine residues in vivo.
Analysis of prmt-5-deficient worms indicated that methylation promoted the dopamine-mediated modulation of chemosensory and locomotory behaviors through the DOP (zeige COPB2 Antikörper)-3 receptor.
data confirm that MEP50 (zeige WDR77 Antikörper) plays a key role in substrate recognition and activates PRMT5 activity by increasing its affinity for protein substrates.
the substrate specificity, processivity, and kinetic mechanism of bacterially expressed Caenorhabditis elegans PRMT5 (cPRMT5).
analysis of structural insights into protein arginine symmetric dimethylation by PRMT5
PRMT-5 represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53 (zeige TP53 Antikörper)-dependent apoptosis.
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).
72 kDa ICln-binding protein
, HMT1 hnRNP methyltransferase-like 5
, SKB1 homolog
, histone-arginine N-methyltransferase PRMT5
, jak-binding protein 1
, protein arginine N-methyltransferase 5
, shk1 kinase-binding protein 1 homolog
, protein arginine methyltransferase 5
, Jak-binding protein 1
, putative arginine N-methyltransferase, type II
, protein arginine methyltransferase
, protein arginine N-methyltransferase 5-like