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Data indicate a pioneer factor model in which c-Myb binds to regions of closed chromatin and then recruits histone acetyltransferases. By binding to histones, c-Myb facilitates histone acetylation, acting as a cofactor for p300 (zeige EP300 Proteine) at c-Myb binding sites. The resulting H3K27ac leads to chromatin opening and detachment of c-Myb from the acetylated chromatin.
Both cases harbored the MYB-NFIB (zeige NFIB Proteine) gene fusion as demonstrated by FISH and RNA-sequencing
Expression of c-Myb, a regulatory factor of B lymphocytes, is increased in B lymphocytes of AIHA/Evans patients, while miR (zeige MLXIP Proteine)-150 expression is decreased. c-Myb was negatively correlated with miR (zeige MLXIP Proteine)-150.
genome-wide association analyses identified a new genome-wide significant locus on the HBS1L (zeige HBS1L Proteine)-MYB intergenic region for platelet-to-lymphocyte ratio
identified a high frequency of MYB rearrangements that promoted the MYB transcriptional activity in BPDCN. MYB split FISH analysis can constitute a valuable diagnostic tool for detecting MYB rearrangements
Studied association of BCL11A single nucleotide polymorphisms(snps) and HBS1L-MYB Intergenic snps with Hereditary Persistence of Fetal Hemoglobin (HPFH) in a cohort of sickle cell patients.
NFIB (zeige NFIB Proteine)-associated gene rearrangement is a frequent genetic event in vulvar adenoid cystic carcinomas. Chromosome translocations involving NFIB (zeige NFIB Proteine) but with an intact MYB indicate the presence of novel oncogenic mechanisms for the development of adenoid cystic carcinomas of the vulva.
Expression of the MYB-NFIB (zeige NFIB Proteine) fusion oncogene (zeige RAB1A Proteine) in mammary tissue resulted in hyperplastic glands that developed into adenocarcinoma.
A trend toward superior PFS was noted with the MYB/NFIB (zeige NFIB Proteine) rearrangement, although this was not statistically significant. NGS revealed three tumors with 4q12 amplification, producing increased copies of axitinib-targeted genes PDGFR (zeige PDGFRB Proteine)/KDR (zeige KDR Proteine)/KIT.
Rearrangement of MYB did not affect OS.
these results identify a key role for miR (zeige MLXIP Proteine)-150 in memory CD8 (zeige CD8A Proteine) T cells through a c-Myb-controlled enhanced survival circuit.
Myb knockdown in Setbp1 (zeige SETBP1 Proteine) and Setbp1 (zeige SETBP1 Proteine) missense mutations-induced AML (zeige RUNX1 Proteine) cells also efficiently induced their differentiation in culture and significantly prolonged the survival of their secondary recipient mice.
These findings reveal miR (zeige MLXIP Proteine)-301b as a new controller of inflammatory response by repressing c-Myb function to inhibit the anti-inflammatory response to bacterial infection, representing a novel mechanism for balancing inflammation.
The analysis points to a critical role for Hoxa9 (zeige HOXA9 Proteine) and PU.1 in distal regulation of c-myb expression in murine myeloid cells during iL-6 (zeige IL6 Proteine)-induced cell differentiation.
Data suggest that the upregulations of Myb and Peg3 are likely the key anti-cancer events of EGCG in vivo.
deficiency alters the expression of a crucial subset of TAL1 (zeige TAL1 Proteine)- and NOTCH1 (zeige NOTCH1 Proteine)-regulated genes, including the MYB and MYC (zeige MYC Proteine) oncogenes, respectively.
MYB acts on MAPK (zeige MAPK1 Proteine) signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2 (zeige SPRY2 Proteine).
This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (zeige AKAP17A Proteine) development to prevent mistimed dsDNA breaks and their deleterious consequences.
These results Myb as a critical component of the gene regulatory network controlling effector Treg cell differentiation and function.
Myb expands the ISC pool within which CRC (zeige SCRIB Proteine) is initiated while co-operating with TSG (zeige TWSG1 Proteine) loss
studies show that merestinib effectively blocks eIF4E phosphorylation in AML (zeige RUNX1 Proteine) cells and suppresses primitive leukemic progenitors from AML (zeige RUNX1 Proteine) patients in vitro and in an AML (zeige RUNX1 Proteine) xenograft model in vivo.
cMyb plays a hitherto unidentified role in dictating physiologic HSPC (zeige PSMA7 Proteine) migration by modulating Sdf1a (zeige CXCL12 Proteine) signaling.
show that knockdown of miR (zeige MYLIP Proteine)-126 results in increased c-Myb levels and promotes erythropoiesis at the expense of thrombopoiesis in vivo
Results suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution.
expression of CD41 and cmyb marks nascent HSCs in the zebrafish AGM (zeige IGFBP7 Proteine), and provide the means to further dissect HSC (zeige FUT1 Proteine) generation and
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
c-myb protein (140 AA)
, proto-oncogene c-Myb
, transcriptional activator Myb
, gag-myb protein
, myb proto-oncogene protein
, myeloblastosis proto-oncogene product
, tumor-specific myb protein
, myeloblastosis oncogene
, Avian myeloblastosis viral (v-myb) oncogene homolog
, v-myb myeloblastosis viral oncogene homolog (avian)
, transcriptional activator Myb-like
, DNA-binding transcriptional regulator
, c-myb proto-oncogene
, transcription factor cmyb
, v-myb myeloblastosis viral oncogene homolog
, v-myb avian myeloblastosis viral oncogene homolog