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Human Polyclonal MEOX1 Primary Antibody für WB - ABIN1881549
Petropoulos, Gianakopoulos, Ridgeway, Skerjanc: Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells. in The Journal of biological chemistry 2004
Meox1 initiates G2 cell-cycle arrest within muscle stem cells, and disrupting this G2 arrest causes premature lineage commitment and the resulting defects in muscle growth.
study reveals the molecular basis for a novel somite lineage restriction mechanism (controlled by meox1) and defines a new paradigm in induction of definitive hematopoietic stem cells
MEOX1 is a clinically relevant novel target in BCSCs and mesenchymal-like cancer cells in PTEN-deficient trastuzumab resistant breast cancer and may serve as target for future drug development.
The G > A p.Q84X mutation in the MEOX1 is identified in Klippel-Feil syndrome.
We describe a multiplex consanguineous family in which isolated KFS maps to a single 17q21.31 locus that harbors a homozygous frameshift deletion in MEOX1; this deletion results in complete instability of the transcript
The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers.
No mutations were identified in the PAX1 and MEOX1 exons or flanking intronic sequences, excluding them as likely causative genes for diaphanospondylodysostosis
transcriptional regulator Meox1 controls TGF-beta-induced SMC differentiation from mesenchymal progenitor cells by preventing PPM1A-mediated Smad3 dephosphorylation
MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner.
Meox1 expression is downregulated in the second arch of Hoxa2 mouse mutant embryos.
Results demonstrate that Meox1 and Meox2 genes function together and upstream of several genetic hierarchies that are required for the development of somites.
Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9.
Meox and Gli have roles in skeletal myogenesis
Data sugges that Meox1 is part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal sclerotome polarity and axial skeleton formation.
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.
Mox-1 related protein
, homeobox protein MOX-1
, mesenchyme homeo box 1
, mesenchyme homeobox 1
, Homeobox protein MOX-1