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Human Monoclonal KAT2A Primary Antibody für ICC, IF - ABIN2668945
Brand, Moggs, Oulad-Abdelghani, Lejeune, Dilworth, Stevenin, Almouzni, Tora: UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. in The EMBO journal 2001
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findings reveal an important mechanism of histone modification and demonstrate that local generation of succinyl-CoA (zeige OXCT1 Antikörper) by the nuclear alpha-KGDH complex coupled with the succinyltransferase activity of KAT2A is instrumental in histone succinylation, tumour cell proliferation, and tumour development
GCN5 upregulation is especially common in UCCs. GCN5 knockdown impeded growth of specific UCCs, whereas PCAF (zeige KAT2B Antikörper) knockdown elicited minor effects.
Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells.
This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 (zeige WDR5 Antikörper) and KAT2A complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
To understand how Gcn5 discriminates between different acyl-CoA molecules, structures of the catalytic domain of human Gcn5L2 bound to propionyl-CoA and butyryl-CoA were determined.
Data suggest that expression of GCN5 (histone acetyltransferase GCN5) is induced in skeletal muscle during a 48-hour fast; in contrast, expression of SIRT1 (sirtuin 1 (zeige SIRT1 Antikörper)) remains unchanged.
Orc5 (zeige ORC5 Antikörper) associates with the H3 histone (zeige HIST1H3B Antikörper) acetyl transferase (zeige HAT1 Antikörper) GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5 (zeige ORC5 Antikörper).
Methionine was the only essential amino acid that rapidly induced PGC-1alpha acetylation through activating the GCN5 acetyltransferase.
these results may point to the GCN5-NF-kappaB (zeige NFKB1 Antikörper) pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis.
Acetyltransferase p300 (zeige EP300 Antikörper) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4 (zeige CHD4 Antikörper)) to facilitate DNA double-strand break repair
study revealed GCN5-mediated EGR2 (zeige EGR2 Antikörper) acetylation as a molecular mechanism that regulates iNKT development.
The results demonstrated that Islet1 (zeige ISL1 Antikörper) upregulated expression of general control of amino acid biosynthesis protein 5 (zeige CAPS Antikörper) (Gcn5) and enhanced the binding of Gcn5 to the promoters of GATA binding protein 4 (GATA4 (zeige GATA4 Antikörper)) and NK2 homeobox 5 (Nkx2.5 (zeige NKX2-5 Antikörper)). In addition, Islet-1 (zeige ISL1 Antikörper) downregulated DNA methyltransferase (zeige DNMT1 Antikörper) (DNMT)1 (zeige DNMT1 Antikörper) expression and reduced its binding to the GATA4 (zeige GATA4 Antikörper) promoter.
recovering GCN5 expression in vivo by lentiviral expression vector significantly attenuated the loss of angiogenesis in ovariectomized mouse femurs
study reveals previously unknown physiological functions for Gcn5 and a molecular mechanism underlying these functions in regulating T cell immunity; Gcn5 may be an important new target for autoimmune disease therapy
Together, our experiments identify a novel nonhistone substrate of GCN5, highlight an essential role for both GCN5 and RA signaling in early diencephalic development, and elucidate a novel molecular regulatory mechanism for RA signaling that is specific to the developing forebrain.
In addition to reducing atrogene expression, surprisingly inhibiting NF-kappaB (zeige NFKB1 Antikörper) with IkappaBalpha (zeige NFKBIA Antikörper)-SR or by GCN5 knockdown in these muscles also enhanced AKT (zeige AKT1 Antikörper) and mechanistic target of rapamycin (mTOR (zeige FRAP1 Antikörper)) activities, which also contributed to the reduction in atrophy.
Gcn5 and PCAF (zeige KAT2B Antikörper) repress IFN-beta (zeige IFNB1 Antikörper) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (zeige TBK1 Antikörper) in the cytoplasm.
GCN5 and HDAC1 (zeige HDAC1 Antikörper) are the crucial enzymes that regulating epigenetic reprogramming; we observed dynamic changes in the expression levels of GCN5 and HDAC1 (zeige HDAC1 Antikörper) during embryo development
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009
histone acetyltransferase KAT2A
, general control of amino acid synthesis 5-like 2
, GCN5 general control of amino-acid synthesis 5-like 2
, general control of amino acid synthesis protein 5-like 2
, K(lysine) acetyltransferase 2A
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
, General control of amino acid synthesis, yeast, homolog-like 2
, histone acetyltransferase GCN5
, lysine acetyltransferase 2A
, GCN5 general control of amino acid synthesis-like 2
, general control of amino acid synthesis, yeast homolog-like 2
, general control of amino acid synthesis-like 2