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In Pakistani population, the frequency of GCB (zeige GBA Proteine) type DLBCL [diffuse large B cell lymphoma ]expressing CD10 (zeige MME Proteine) and BCL6 (zeige BCL6 Proteine) is 37.5%, and non- GCB (zeige GBA Proteine) type DLBCL [diffuse large B cell lymphoma ] expressing MUM1 is 62.5%.
Study confirmed a significant role for IRF4 rs12203592 and SLC45A2 (zeige SLC45A2 Proteine) rs16891982 in the risk of cutaneous squamous cell carcinoma development in organ transplant recipients.
IRF4 is overexpressed in human non-small cell lung cancer and activates the Notch (zeige NOTCH1 Proteine) signaling pathway.
IRF4 signaling is essential for activin A (zeige INHBA Proteine) induced regulatory T cells that restrain asthmatic responses.
The data indicate that USP4 (zeige USP4 Proteine) interacts with and deubiquitinates IRF4, and also stabilizes IRF4 protein and promotes IRF4 function to facilitate IL-4 (zeige IL4 Proteine) expression in Th2 cells, which may be related to the pathological process of rheumatic heart disease.
IRF4 is an independent prognostic factor for general MM patients.
Data show that the host transcript of miR (zeige MLXIP Proteine)-223, linc-223, as a novel functional long non-coding RNA (lncRNA) and induces interferon regulatory factor 4 (IRF4) expression in acute myeloid leukemia (zeige BCL11A Proteine).
Evidence for an essential role of Notch (zeige NOTCH1 Proteine) signaling in the development of chronic lymphocytic leukemia (CLL) and establish IRF4 as a critical regulator of Notch (zeige NOTCH1 Proteine) signaling during CLL development.
These results show that significantly increased levels of FOXO3 (zeige FOXO3 Proteine), IRF4, and xIAP (zeige XIAP Proteine) mRNA in Chinese HIV-1-infected patients.
Mechanistically, we found that BETi-mediated inhibition of cMYC (zeige MYC Proteine) correlates with the upregulation of miR (zeige MLXIP Proteine)-125b-5p and the downregulation of the cMYC (zeige MYC Proteine)/miR (zeige MLXIP Proteine)-125b-5p target gene IRF4, a transcriptional repressor of MICA (zeige MICA Proteine).
Furthermore, chromatin immunoprecipitation (ChIP) followed by luciferase assays revealed direct binding of Foxo1 (zeige FOXO1 Proteine) to both the Il9 (zeige IL9 Proteine) and Irf4 promoters and induces their transactivation.
MBD2 (zeige MBD2 Proteine) Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression
study identifies IRF4 as central regulator of TH1 (zeige HAND1 Proteine) responses and cellular metabolism. We propose that this function of IRF4 is fundamental for the initiation and maintenance of all TH cell responses.
Nur77 (zeige NR4A1 Proteine) suppresses CD4 (zeige CD4 Proteine)(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 (zeige GATA3 Proteine)(+) and IL-4 (zeige IL4 Proteine)(+) cells.
Muramyl dipeptide reduces fat inflammation and liver insulin (zeige INS Proteine) resistance via NOD2. NOD1 (zeige NOD1 Proteine)-activating muropeptides exacerbate glucose intolerance. IRF4 dictates insulin (zeige INS Proteine)-sensitizing effects of NOD2, but not NOD1 (zeige NOD1 Proteine), muropeptides.
Young mice had higher levels of IRF4 in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.
IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection.
The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3 (zeige GATA3 Proteine), SATB1 (zeige SATB1 Proteine), and IRF4.
this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells
IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
lymphocyte-specific interferon regulatory factor
, multiple myeloma oncogene 1
, PU.1 interaction partner
, Sfpi1/PU.1 interaction partner
, transcriptional activator PIP
, interferon regulatory factor 4
, Interferon regulatory factor 4
, PWWP domain-containing protein MUM1
, melanoma associated antigen (mutated) 1