anti-FOXP3 (FOXP3) Antikörper

Zebrafish Forkhead Box P3 (FOXP3) Interaktionspartner

1. analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish

2. correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses

Atlantic Salmon (Salmo salar) Forkhead Box P3 (FOXP3) Interaktionspartner

1. cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals

Human Forkhead Box P3 (FOXP3) Interaktionspartner

1. Study suggests that asthma is significantly associated with higher differentially methylated regions within the promoter region of Foxp3 and positively linked with average exposure to CO,NO2, and PM2.5 during the 90 days prior to the blood draw.

2. There was a significant positive correlation between the expression of EBI3 and Foxp3 mRNA in the sarcoidosis group (r=0.786, P<0.001). Conclusion: IL-35 may be involved in the inflammatory process of sarcoidosis and play an important role in the pathogenesis of the disease.

3. TGF-b, IL-10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer

4. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing

5. Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha.

6. RUNX3, a CD8(+) lineage-specific transcription factor, binds at the FOXP3-promoter to induce its transcription.

7. Multivariate analysis of OS only found CD8(+)/Foxp3(+) ratio to be independent prognostic factor (P = 0.022) om spinal chordoma.

8. Treg cells from asthmatic patients expressed more FOXP3 as well as GATA3; the expression level of GATA3 negatively correlated with FEV1%pred. Increased expressions of USP21 and PIM2 in Treg cells from asthmatic patients were found.

9. Authors have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation. Study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4(+) T cells of CRC patients.

10. Early-pregnancy decidual mRNA expression of the regulatory T-cell marker, FOXP3, was sixfold lower (p < 0.01) in pregnancies with a male fetus compared to pregnancies with a female fetus.

11. In conclusion we suggest that genetic variants in FOXP3 gene may contribute to the pathogenesis of preeclampsia.

12. Data show that the forkhead Box Protein P3 (FOXP3) response element at the -310 bp region, but not the -2182 bp region, is mainly required for ubiquitin conjugating enzyme 9 (UBC9) activation by FOXP3.

13. The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability.

14. The concurrent overexpression of FoxM1 and FoxP3 was evident in gastric cancer and inversely correlated with patient survival.

15. Results suggest that -924A/G and +459T/C polymorphisms of the FOXP3 gene might be associated with unexplained recurrent spontaneous abortions (URSA) and -20G/A polymorphism is likely to be rare in Indian population and might not be associated with URSA.

16. mutations can cause early-onset insulin-requiring diabetes with or without other features of IPEX syndrome

17. The rs3761549, rs5902434, and rs2232365 are associated with an increased risk of acute graft-versus-host disease and decreased risk of post allogenic hematopoietic stem cell transplantation.

18. Genetic variations at SNP rs3761548 in the FOXP3 gene represent a risk factor for peptic ulcer.

19. Aberrant expression and methylation patterns of FoxP3 were detected in human T cells.

20. blood mononuclear cells in stable CAD patients express a ratio of FOXP3 isoforms that is characteristic for activated CD4+ T cells

Mouse (Murine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. Here we focus on the cytokines implicated in thymic development of Treg(T lymphocytes (Treg) expressing the transcription factor Foxp3), with a particular emphasis on the roles of interleukin-2 and IL-15

2. It has been shown that T-cell receptors-activated post-translational modification by O-linked N-Acetylglucosamine stabilizes FOXP3 and activates STAT5, thus integrating these critical signaling pathways.

3. This study demonstrated that adoptive transfer of CD4(+)CD25(+) Tregs can decrease mouse enteritis. Foxp3 expression may be improved through the Smad3 and NFAT2 signalling pathways.

4. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing

5. the strength of TCR stimulation is a key factor for induction of the demethylation of Foxp3 conserved non-coding sequence 2 and the generation of stable Tregs

6. Stable Foxp3 expression in extrathymically induced regulatory T cells (iTreg) requires Forkhead box protein P1 (Foxp1). Foxp1 binds a promoter region and genetic elements, including three CNSs (CNS1-3) downstream of the transcriptional start site of Foxp3 to preserve permissive histone modifications.

7. Epigenetic modification is also thought to take essential part into the upregulation of Foxp3 from naive CD4 + Tcells.

8. Foxp3 vaccine promotes an immune response against tumor.

9. Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model

10. This study reports on systematic alanine-scan mutagenesis of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression.

11. Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R)

12. Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease

13. Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3(+) precursors in autoimmunity has been described.

14. KLRG1 expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.

15. Novel regulatory T-cells that are induced by B cells and do not express Foxp3 and IL-10 alleviate intestinal inflammation in vivo.

16. the findings suggested that excreted-secreted antigens restricted Foxp3 expression by inhibiting TGFssRII/Smad2/Smad3/Smad4 signalling, ultimately resulting in abortion.

17. Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 in co-cultures of dendritic cells and CD4+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 = homing receptor)

18. Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.

19. Dendritic cells have the capacity to express Foxp3, which can be upregulated by exposure to Staphylococcal enterotoxin B.

20. the Treg transcription factor Foxp3 reprograms T cell metabolism by suppressing Myc and glycolysis, enhancing oxidative phosphorylation, and increasing nicotinamide adenine dinucleotide oxidation.

Pig (Porcine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids

2. In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection

Cow (Bovine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.

2. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4.

3. regulatory role in intramuscular fat deposition

4. The expression of Foxp3 in CD4(+) T cells from persistent lymphocytotic cattle was significantly increased.

5. There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.

6. identification of Foxp3 expression in Treg cells

7. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population

Horse (Equine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. The correlation of TH17-related TLR4 expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.

2. Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.

3. results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response