anti-FOXP3 (FOXP3) Antikörper

Zebrafish Forkhead Box P3 (FOXP3) Interaktionspartner

1. analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish

2. correlation between the expression of t-bet, stat6 (zeige STAT6 Antikörper) and foxp3 with other genes involved in Th and T(reg (zeige KCNH2 Antikörper)) responses

Atlantic Salmon (Salmo salar) Forkhead Box P3 (FOXP3) Interaktionspartner

1. cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals

Human Forkhead Box P3 (FOXP3) Interaktionspartner

1. Foxp3 is associated with lymphangiogenesis of cervical cancer.

2. Polymorphic marker -3279 C>A of the FOXP3 gene was not associated with the risk of Pulmonary Sarcoidosis patients of Russian ethnicity.

3. Data show that forkhead box P3 protein (zeige SLC10A3 Antikörper) (FOXP3) protein not only binds with DNA sequences containing one FKH (zeige FOXA1 Antikörper) consensus sequence, but also binds with DNA sequences with two direct repeats of consensus sequences separated by three-nucleotides (DRE3).

4. Study identifies CCR8 (zeige CCR8 Antikörper)+ regulatory T cells (Treg cells) as drivers of immunosuppression and provides compelling evidence of a self-feeding mechanism by which, at an autoimmune site, CCL1 (zeige CCL1 Antikörper) produced by FOXp3+ Treg cells upregulates the expression of its own receptor, CCR8 (zeige CCR8 Antikörper), on these cells, and potentiates their in vivo proliferation and suppressive activities as driver Treg cells.

5. our findings suggest that FOXP3 suppresses tumor progression in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) via TGF-b/Smad2 (zeige SMAD2 Antikörper)/3 signaling pathway, highlighting the role of FOXP3 as a prognostic factor and novel target for an optimal therapy against this fatal malignancy

6. Studied lymphocyte phenotype in resected lymph nodes of patients with lung cancer by analyzing levels of Foxp3 and CD8 (zeige CD8A Antikörper) by immunohistochemical staining.

7. We conclude that Foxp3 promoter polymorphisms are associated with susceptibility to endometrial cancer in Chinese Han women.

8. Studied the association between Foxp3 gene polymorphisms and the susceptibility to differentiated thyroid cancers in a Chinese Han population.

9. DLBCL cases with high FOXP3 have longer survival (P=0.03). T cells in the background of DLBCL may play a role in modulation of tumor progression. Their presence is associated with favorable prognostic parameters in DLBCL

10. no significant association between rs3761548, rs2232365 polymorphisms of the FOXP3 gene, and an increased susceptibility to allergic rhinitis [meta-analysis]

Mouse (Murine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. This study reports on systematic alanine-scan mutagenesis of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression.

2. Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 (zeige CD200 Antikörper) through its receptor (CD200R (zeige CD200R1 Antikörper))

3. Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease

4. Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3(+) precursors in autoimmunity has been described.

5. KLRG1 (zeige KLRG1 Antikörper) expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.

6. Novel regulatory T-cells that are induced by B cells and do not express Foxp3 and IL-10 (zeige IL10 Antikörper) alleviate intestinal inflammation in vivo.

7. the findings suggested that excreted-secreted antigens restricted Foxp3 expression by inhibiting TGFssRII/Smad2 (zeige SMAD2 Antikörper)/Smad3 (zeige SMAD3 Antikörper)/Smad4 (zeige SMAD4 Antikörper) signalling, ultimately resulting in abortion.

8. Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 (zeige CD44 Antikörper) in co-cultures of dendritic cells and CD4 (zeige CD4 Antikörper)+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 (zeige CD44 Antikörper) = homing receptor)

9. Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.

10. Dendritic cells have the capacity to express Foxp3, which can be upregulated by exposure to Staphylococcal enterotoxin B.

Pig (Porcine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids

2. In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection

Cow (Bovine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.

2. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4 (zeige CTLA4 Antikörper).

3. The expression of Foxp3 in CD4 (zeige CD4 Antikörper)(+) T cells from persistent lymphocytotic cattle was significantly increased.

4. There is a positive correlation between the intensity of CD25 (zeige IL2RA Antikörper) expression and the expression of the transcription Foxp3 factor in bovine CD8 (zeige CD8A Antikörper)(+) cells.

5. identification of Foxp3 expression in Treg cells

6. These findings revealed that despite the existence of a distinct bovine CD4 (zeige CD4 Antikörper)(+)CD25 (zeige IL2RA Antikörper)(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population

Horse (Equine) Forkhead Box P3 (FOXP3) Interaktionspartner

1. The correlation of TH17-related TLR4 (zeige TLR4 Antikörper) expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.

2. Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.

3. results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response