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FOXP3 Antikörper (Forkhead Box P3) (PE) Primary Antibody

FOXP3 Reaktivität: Human, Maus FACS, WB Wirt: Maus Monoclonal 3G3 PE
Pubmed (2 references)
Produktnummer ABIN1303119
$584.43
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle FOXP3 Antikörper anzeigen
    FOXP3
    Reaktivität
    • 186
    • 128
    • 47
    • 41
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 122
    • 74
    • 12
    • 9
    • 2
    Maus
    Klonalität
    • 131
    • 90
    Monoklonal
    Konjugat
    • 97
    • 19
    • 14
    • 12
    • 12
    • 8
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser FOXP3 Antikörper ist konjugiert mit PE
    Applikation
    • 119
    • 104
    • 86
    • 49
    • 48
    • 27
    • 26
    • 18
    • 17
    • 16
    • 16
    • 10
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Western Blotting (WB)
    Spezifität
    The mouse monoclonal antibody 3G3 recognizes N-terminal region of FoxP3, a 47-55 kDa transcription factor, which is the master regulator in the development and function of regulatory T cells.
    Kreuzreaktivität (Details)
    Human, Mouse
    Immunogen
    Full-length His-tagged recombinant murine FoxP3
    Klon
    3G3
    Isotyp
    IgG1
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis.Suggested working concentration is 3 µ,g/mL. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Law, Hirschkorn, Owen, Biswas, Norris, Lanteri: "The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 75, Issue 12, pp. 1040-50, (2009) (PubMed).

    Gavin, Torgerson, Houston, DeRoos, Ho, Stray-Pedersen, Ocheltree, Greenberg, Ochs, Rudensky: "Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 17, pp. 6659-64, (2006) (PubMed).

  • Target
    FOXP3
    Andere Bezeichnung
    FoxP3 (FOXP3 Produkte)
    Synonyme
    foxp3, FOXP3, AIID, DIETER, IPEX, PIDX, XPID, JM2, scurfin, sf, RGD1562112, forkhead box P3, forkhead box P3a, forkhead box P3 L homeolog, FOXP3, foxp3a, foxp3, foxp3.L, Foxp3
    Hintergrund
    FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.
    Pathways
    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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