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BCL6 forms a complex with BCL6 corepressor (BCoR (zeige BCOR Proteine)) on the promoters of selected Notch (zeige NOTCH1 Proteine) target genes such as enhancer of split related 1.
this study shows that IL4 (zeige IL4 Proteine) and IL21 (zeige IL21 Proteine) cooperate to induce the high Bcl6 protein level required for germinal center formation
Although BCL6 controls follicular helper T cells activity in humans and mice, the role of miR (zeige MLXIP Proteine)-31 is restricted to human follicular helper T cell differentiation, reflecting a species specificity of the miR (zeige MLXIP Proteine)-31 action.
These findings indicate a role of the interaction between TH2-promoting factors and Bcl6 in promoting appropriate IL-4 (zeige IL4 Proteine) production in mTH2 (zeige NUDT15 Proteine) cells and suggest that chronic allergic diseases involve the TH2-promoting factor-mediated functional breakdown of Bcl6, resulting in allergy exacerbation.
Bioinformatics analysis and the dual-luciferase reporter assay demonstrated that miR (zeige MLXIP Proteine)-10b could target the 3'-untranslated regions of B cell lymphoma 6 (Bcl6) which is an important regulator of osteoblast differentiation.
Def6 (zeige DEF6 Proteine) limits proliferation of T follicular helper cells in mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.
The balance between CD4 (zeige CD4 Proteine)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (zeige TCF7 Proteine) (encoding TCF-1 (zeige HNF1A Proteine)) and by the expression of the inhibitory receptors PD-1 (zeige PDCD1 Proteine) and LAG3 (zeige LAG3 Proteine).
Study provides evidence for an essential role of Bcl6 in the complex regulation of gene transcription during early adipogenesis. The action of Bcl6 is at least partially mediated by the direct transcriptional activation of STAT1 (zeige STAT1 Proteine).
These data describe a novel regulatory mechanism through which STAT3 (zeige STAT3 Proteine) and the Ikaros (zeige IKZF1 Proteine) zinc finger transcription factors Aiolos (zeige IKZF3 Proteine) and Ikaros (zeige IKZF1 Proteine) cooperate to regulate Bcl-6 expression.
Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells
data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 (zeige PRDM1 Proteine) control follicular helper T cell differentiation
Cryptic t(3;8)(q27;q24) and/or MYC (zeige MYC Proteine)-BCL6 linkage associated with MYC (zeige MYC Proteine) expression by immunohistochemistry is frequent in multiple-hit B-cell lymphomas
BCL6 overexpression in SHR reduced blood pressure, NLRP3 expression and inflammation in the renal cortex of SHR
Aberrant CD10 (zeige MME Proteine) and BCL6 expression defines a subset of MCLs with higher mean Ki-67 (zeige MKI67 Proteine) index and higher prevalence of MUM1 (zeige IRF4 Proteine) expression
Double-hit lymphoma (DHL) is an aggressive form of DLBCL with an unmet treatment need, in which MYC (zeige MYC Proteine) rearrangement is present with either BCL2 (zeige BCL2 Proteine) or BCL6 rearrangement
BCL6 is a growth promoting factor in glioblastoma and glioma.
IFN gamma induced (zeige SAMHD1 Proteine) upregulation of BCL6 was dependent on the classical STAT1 (zeige STAT1 Proteine) signaling pathway, and affected both major BCL6 variants. Interestingly, although IFN alpha (zeige IFNA Proteine) induced stronger STAT1 (zeige STAT1 Proteine) phosphorylation than IFN gamma (zeige IFNG Proteine), it only slightly upregulated BCL6 in multiple myeloma lines.
Findings demonstrate that BCL6 expression is downregulated by miR (zeige MLXIP Proteine)-519d which targets its 3 '-UTR. Also, BCL6 mediates the repression of miR (zeige MLXIP Proteine)-519d on cell proliferation and invasive capability of gastric cancer cells.
In Pakistani population, the frequency of GCB (zeige GBA Proteine) type DLBCL [diffuse large B cell lymphoma ]expressing CD10 (zeige MME Proteine) and BCL6 is 37.5%, and non- GCB (zeige GBA Proteine) type DLBCL [diffuse large B cell lymphoma ] expressing MUM1 (zeige IRF4 Proteine) is 62.5%.
BCOR (zeige BCOR Proteine) internal tandem duplication and/or nuclear immunoreactivity for BCOR (zeige BCOR Proteine) or BCL6 can aid in the diagnosis of primitive myxoid mesenchymal tumor of infancy and help to differentiate it from congenital infantile fibrosarcoma.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S