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Inhibition of PLSCR1 decreased the antiviral activity of IFN against HBV.
Data suggest that PLSCR1 is involved in viral entry; here, herpes simplex viruses activate PLSCR1 and up-regulate flipping of phosphatidylserines and AKT (zeige AKT1 Proteine) to outside of plasma membrane shortly following HSV-1 or HSV-2 exposure. (PLSCR1 = phospholipid scramblase 1; AKT (zeige AKT1 Proteine) = proto-oncogene c-Akt (zeige AKT1 Proteine))
wogonoside promotes the expression of PLSCR1 and enhances its nuclear translocation and binding to the 1, 4, 5-trisphosphate receptor 1 (IP3R1 (zeige ITPR1 Proteine)) promoter in AML (zeige RUNX1 Proteine) patient-derived primary cells. Wogonoside activates IP3R1 (zeige ITPR1 Proteine), in turn, promotes release of Ca(2 (zeige CA2 Proteine)+) from endoplasmic reticulum, and eventually leads to cell differentiation.
Data indicate heterogeneous expression of phospholipid scramblase 1 (PLSCR1) and suggest its possible implication in the response to anticancer therapies, especially to drugs promoting protective autophagy.
Human phospholipid scramblase 1 has five histidine residues and point mutations of histidine residues to alanine in hPLSCR1 resulted in 60 % loss in nuclease (zeige DCLRE1C Proteine) activity.
directed mutagenesis revealed the importance of c-Myc (zeige MYC Proteine) binding sites from -751 to -756 and -548 to -553 on the promoter of hPLSCR1in transcriptionally regulating the expression of hPLSCR1.
PLSCR1 positively regulates hepatic carcinoma cell proliferation and migration through interacting with midkine (zeige MDK Proteine)
Suggest role for PLSCR1 in negatively regulating trophoblast fusion rather than directly promoting fusion.
PLSCR1 mediates the antiviral activity and anticarcinogenesis against hepatitis B virus by regulating HBx stability.
affinity of SCR for cholesterol-rich domains in membranes
PLSCR1 aggravates anaphylactic reactions by increasing Fc epsion RI-dependent mast cell degranulation.
Genetic knockdown of PLSCR1 activity reduces intracellular calcium dysregulation, prevents phosphatidylserine externalization, and enables months-long protection of vector-transduced, transgene-expressing cells from microglial phagocytosis.
Phospholipid scramblase 1 regulates phosphatidylserine exposure in response to oxygen stress, leading to beta2-glycoprotein I and IgM binding and lipid-mediated, inflammatory responses.
Lipopolysaccharide treatment resulted in increased expression of phospholipid scramblase 1(PLSCR-1) and decrease in phospholipid scramblase 4(Plscr4 (zeige PLSCR4 Proteine) )messenger RNA demonstrating modulation of PLSCR-1 and PLSCR-4 (zeige PLSCR4 Proteine) in lipopolysaccharide-induced preterm birth
Study demonstrates that PLSCR1 is a TLR9 (zeige TLR9 Proteine)-interacting protein that plays an important role in pDC's type 1 IFN responses by regulating TLR9 (zeige TLR9 Proteine) trafficking to the endosomal compartment.
the capacity of PLSCR1 to augment G-CSF (zeige CSF3 Proteine)-dependent production of mature neutrophils from myeloid progenitors is unrelated to its reported activities at the endofacial surface of the plasma membrane but does require entry of the protein into the nucleus
PLSCR1 appears to influence progression of UV-induced apoptosis and could be a point of regulation or intervention during programmed cell death
PLSCR1, which is itself an IFN-stimulated gene-encoded protein, provides a mechanism for amplifying and enhancing the IFN response through increased expression of a select subset of potent antiviral genes
PLSCR1 binds to the promoter region of the IP3R1 (zeige ITPR1 Proteine) gene to enhance its expression
These findings demonstrate a functional interdependence between onzin and PLSCR1.
may act as a downstream mediator of immune response in IgE receptor signaling\; may transport phospholipids in the plasma membrane
phospholipid scramblase 1
, PL scramblase 1
, ca(2+)-dependent phospholipid scramblase 1
, phospholipid scramblase 2
, erythrocyte phospholipid scramblase
, transplantability-associated protein 1
, PL scramblase 2
, ca(2+)-dependent phospholipid scramblase 2