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Results provide clear indication that IL-8 plays key roles in the activation of breast CAAs and acts as a major mediator for their paracrine protumorigenic effects.
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Our findings suggest the possibility of the impact of comorbidities in patients with asthma on systemic inflammation markers, especially IL-6 and IL-8.
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IL-8 elevation in aqueous humor is a significant risk factor both for detecting and managing glaucoma and may serve as a therapeutic target candidate to improve the prognosis of glaucoma surgery.
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identified autocrine expression of the cytokines CXCL8 and IL11 as the target genes of CUL1 in breast cancer cell migration, invasion, metastasis, and angiogenesis.
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The data indicated that blocking IL-8 derived from gastric cancer mesenchymal stem cells may overcome the immune escape induced by PD-L1 in gastric cancer cells and provide a potential strategy to enhance the immunotherapy efficiency in gastric cancer.
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Analysis of miR-21, IL-6, and IL-8 in the plasma of peripheral blood was performed at baseline. Patients with high circulating levels of >/=2 of the three inflammation markers (miR-21, IL-6, and IL-8) were considered to have the "Inflammation phenotype-positive CISIG"
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studies suggest that the E70K CXCL8 peptide, may serve as a lead molecule for further development of therapeutic inhibitors of neutrophil-mediated inflammation based on modulation of chemokine-GAG binding.
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The present study provided further evidence for the role of IL-8 in suicide behavior.
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The data suggest that Tp92 recognizes CD14 and TLR2, transfers the signal to a downstream pathway, and activates NF-kappaB to mediate the production of IL-8. This mechanism may help T. pallidum escape recognition and elimination by the host innate immune system.
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findings reveal a previously unrecognized function of exosomal NAP1 derived from oral cancer cells in enhancing the cytotoxicity of NK cells via the IRF-3 pathway
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An analysis in B cells confirms the strong dependency on NAP1-mediated H1 eviction for induction of the silent CD40 gene and further demonstrates that H1 eviction, seeded by activator-p300-NAP1-H1 interactions, is propagated over a CCCTC-binding factor (CTCF)-demarcated region through a distinct mechanism that also involves NAP1
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CXCL8 is predominantly secreted by macrophages and contributes to the immunosuppressive microenvironment by inducing PD-L1(+) macrophages in gastric cancer. CXCL8 inhibitors may drive antitumour response, providing potential therapeutic effects for patients with gastric cancer.
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Serum chemokine CXCL8 is a better biomarker for diagnosis and prediction of pancreatic cancer than its specific receptor CXCR2, C-reactive protein, and classic tumor markers CA 19-9 and CEA.
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There were no significant relationships between alcohol consumption or cannabis use and IL-8 found.
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TNFalpha by itself has no effect on the secretion of CXCL10, whereas it increases dose-dependently the secretion of CXCL8 in Graves' thyrocytes, and in Grave's opthalmopathy fibroblasts and preadipocytes, while IFNgamma does stimulate the secretion of CXCL10 but it inhibits that of CXCL8. This differential modulation of CXCL10 and CXCL8 chemokines may reflect a different role of the two chemokines in the course of the ...
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Compared with normal controls, circulating IL-8 levels in systemic lupus erythematosus patients are elevated and affected by age, region and disease duration.
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High serum IL8 expression is associated with drug resistance in breast cancer.
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High levels of circulating IL-8 were associated with large infarct size, impaired recovery of left ventricular function, and adverse clinical outcome in patients with acute ST-segment elevation myocardial infarction.
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Since acquisition of GemR increased IL8 production and consequently increased tumor angiogenesis, the IL8/CXCR2 axis may be a potential novel therapeutic target for PaCa after acquiring GemR.
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The results demonstrated that interactions between ameloblastoma cells and bone marrow stromal cells (BMSCs) increased interleukin (IL)8 and activin A secretion by BMSCs.