anti-Interleukin 8 (IL8) Antikörper

Human Interleukin 8 (IL8) Interaktionspartner

1. The luteal phase of the cycle in perimenstrual asthma patients is associated with increased serum estradiol levels with concurrent higher sputum concentration of IL-5 and IL-8.

2. The increased levels of serum procollagen 1 C-terminal peptide in COPD might indicate the condition of airway remodeling, and IL-6 and/or IL-8 might play an important role in stimulating collagen synthesis.

3. CXCL8-signaling is a prominent and distinctive feature of abdominal aortic aneurysm (AAA), interference with the pathway constitutes a promising target for medical stabilization of AAA.

4. inflammatory markers IL8 and NFKB are reduced in human cells in a process mediated by branched-chain fatty acid vernix-monoacylglycerides

5. interleukin 8 cytokines in cervical cancer is associated with the degree of malignancy

6. CXCL8 levels were not higher in n chronic obstructive pulmonary disease and asthma-COPD overlap patients than in interstitial pneumonia patients

7. Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes.

8. Increased serum concentrations of interleukin IL-6, IL-8, and TNF-alpha may suggest that these cytokines induce inflammatory changes in the ocular surface.

9. IL-6 and IL-8 were significantly elevated in preterm infants with definitive surgical necrotizing enterocolitis but not those with feeding intolerance.

10. High serum IL8 level is associated with pancreatic cancer.

11. GPER can suppress the migration and invasion of OS cells via inhibition of IL-6 and IL-8

12. Blocking androgen receptor signaling in cancer-associated fibroblasts -like cells increases prostate cancer cell migration mediated by increased secretion of CCL2 and CXCL8.

13. Measuring IL-2 and IL-8 in the serum may be a surrogate marker of the immunosuppressive status of kidney transplant recipients

14. chronic lymphocytic leukemia B cells are not able to secrete or respond to IL-8.

15. findings show that reduced PHB1 expression induces IL-8 transcription by activating NF-kappaB and AP-1, resulting in enhanced IL-8 expression and release to promote tumorigenesis.

16. The present results demonstrated that IL8 increased EpCAM expression at the mRNA level in ovarian cancer cells and suggested a potential role of IL6 as an inhibitor of IL8stimulated EpCAM expression.

17. In vitro IL-8 production by IL-27 and IL-37 pre-treated neutrophils and monocytes was significantly inhibited.

18. Chemoresistance in ovarian cancer cells persists through the establishment of an autocrine IL8 loop.

19. A study of the down-regulation of Platelet-activating factor-induced IL-8 expression, by PTP1B, showed modulation of PAF-induced transactivation of the IL-8 promoter which was dependent on the presence of the C/EBPss -binding site.

20. we showed for the first time that CXCL8-CXCR1 autocrine signaling regulates colon cancer tumorigenicity initiated by patient-derived CCSCs.

Cow (Bovine) Interleukin 8 (IL8) Interaktionspartner

1. Molecular characterization of the bovine IER3 gene: Down-regulation of IL-8 by blocking NF-kappaB activity mediated by IER3 overexpression in MDBK cells infected with bovine viral diarrhea virus-1.

2. STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.

3. As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.

4. Blood levels of cortisol, immunoglobulin G, and IL-8 in relationship to genetics and the incidence of bovine respiratory complex disease are reported.

5. Genetic variation at the IL8 locus explains a proportion of the inter-breed and inter-individual variation in immunity between neonatal calves which is likely to influence their resistance to infection.

6. In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle.

7. Studied association of IL8 -105G/A with mastitis somatic cell score in Chinese Holstein dairy cows. Results suggest genotype GG may be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein dairy cows.

8. Data implicate a complex cascade of events during luteolysis, involving Il8 signaling, neutrophil recruitment, and immune cell action within the corpus luteum.

9. Cadmium exposure induced pulmonary inflammation and increased lung interleukin 8 secretion.

10. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.

11. study demonstrates that a small experimental rodent model can be utilized for non-invasively monitoring, through a reporter gene system, the activation of an IL-8 promoter region derived from a larger size animal (bovine)

12. Finding of genetic variation in the IL8 promoter that differentially regulates its expression has significant functional implications for IL8 expression in vitro and which may impact on susceptibility to infectious disease and inflammation.

13. Polymorphonuclear neutrophils migrate into the early corpus luteum(CL) partially due to its major chemoattractant IL-8 produced at high levels in the CL.

14. IL8 genotype significantly correlated with mastitis resistance and the locus could be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein.

15. IL8 promoter serial deletion analysis revealed a specific region responsive to ORF50/Rta; may represent an endometrial defense mechanism against viral infection

16. IL8 gene genetic diversity has a great genetic effect on milk traits and mastitis resistance

17. The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.

18. Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.

19. Levels in milk are altered in the presence of bacteria

20. C-terminal of both bovine IL-8R showed 100% identity, whereas they differ in most other species, suggesting that the two bovine IL-8R initiate similar signal transduction.

Pig (Porcine) Interleukin 8 (IL8) Interaktionspartner

1. This study evaluated the subcellular localization and other functions of TGEV nsp7 protein through analysis of its effects on cell growth, cell cycle progression, interleukin 8 (IL-8) expression, and NF-kappaB activation.

2. The JNK-activated AP-1 subunit c-Jun was critical for the up-regulation of IL-8 expression by PRRSV

3. These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88/NF-kappaB signalling pathway.

4. Facilitated degradation of the RGS16 by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 and IL-8 mRNA transcripts.

5. Suggest that the interplay between TGFbeta-2 and LPS regulates the levels of IL-8 in the immature newborn intestine.

6. downregulated gene expression elite controllers (fraction of human population displaying resistance to HIV infection)

7. Data suggest that MSK1 and MSK2 are the major CREB kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 at Ser-133 plays a significant role in IL-8 production.

8. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta, IL-8 and TNF-alpha in porcine alveolar macrophages.

9. local expression of IL-1beta and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls

10. In swine, IL-8, TNF-ALPHA, INOS AND MIP-1BETA were increased during mechanical ventilation in a time-related fashion.

11. Classical swine fever virus NS2 protein promotes interleukin-8 expression.

12. Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth

Rhesus Monkey Interleukin 8 (IL8) Interaktionspartner

1. Stress decreased IL-8 gene expression in both CeA lesioned and non-lesioned animals. But, CeA lesions increased the tissue expression of IL-8 mRNA prior to and after stress exposure.

Zebrafish Interleukin 8 (IL8) Interaktionspartner

1. gene expression and epistasis analysis indicated that CXCL8(IL-8) was a functional target of vitamin D3-mediated HSPC regulation. Together, these findings highlight the relevance of developmental 1,25(OH)D3 availability for definitive hematopoiesis and suggest potential therapeutic utility in HSPC expansion

2. Targeted expression of the human oncogene KRASG12V in zebrafish gills induces inflammation and cxcl8-l1 expression.

3. Data show that both Cxcl8-l1 and Cxcl8-l2 are required for larva survival upon Salmonella Typhimurium infection.

4. results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn oxidation or indirectly by modulating cxcl8 gene expression

5. Zebrafish Cxcl8s play a role in neutrophil recruitment under acute inflammatory conditions.

6. The data identify HOXC9 as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner

7. Here, we report the characterisation of genes encoding the zebrafish Cxcl8, Cxcr1 and Cxcr2

Rabbit Interleukin 8 (IL8) Interaktionspartner

1. At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold

2. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.

3. The JNK pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.

4. IL-8 and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis

Horse (Equine) Interleukin 8 (IL8) Interaktionspartner

1. Results suggested that chemokine expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.

2. Mapped six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.

3. This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

4. These results suggest that MMP-1 and IL-8 are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

5. The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.

Duck Interleukin 8 (IL8) Interaktionspartner

1. Duck IL-8 is good immunostimulant to enhance the immune efficiency of avian influenza vaccine in ducks.

Xenopus laevis Interleukin 8 (IL8) Interaktionspartner

1. IL-8 homologue has been cloned and identified; the chemokine CXC domain, which contained Glu-Leu-Arg motif and four cysteine residues, was well conserved