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Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099
Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. in Journal of immunological methods 1989
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100
Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. in Journal of immunology (Baltimore, Md. : 1950) 1994
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935624
Frøyland, Pedersen, Kvissel, Almaas, Pharo, Skålhegg, Mollnes, Rootwelt: Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons. in Brain research 2006
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935595
Bogen, Dina, Gear, Levine: Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. in Neuroscience 2009
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101
Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. in Molecular and cellular biology 1990
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413564
Zhu, Daghini, Chade, Rodriguez-Porcel, Napoli, Lerman, Lerman: Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension. in Arteriosclerosis, thrombosis, and vascular biology 2006
Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594
Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. in Circulation 2013
High MCP1 expression is associated with pancreatic adenocarcinoma.
Results provide evidence for MCP-1 involvement in the development of PVVs and indicate that inflammation could be implicated in the pathogenesis of this condition.
Study found that the activation of CCR2 (zeige CCR2 Proteine) by its ligand CCL2 increased the expression of SMO and Gli-1 (zeige GLI1 Proteine), resulting in Hh pathway activation, epithelial-mesenchymal transition and hepatocellular carcinoma cell invasion.
these findings collectively indicate that TGF-beta (zeige TGFB1 Proteine) regulates CCL2 expression in a stage-dependent manner during breast cancer progression
REVIEW: regulation and importance of monocyte chemoattractant protein-1
this study shows that CCL2 promoter hypomethylation is associated with gout risk in Chinese Han male population
Results showed that both heterozygous and homozygous genotypes are associated with age-related macular degeneration pathology. Allele frequency analysis showed that 'G' allele is frequent in AMD (zeige AMD1 Proteine) patients as compared to controls
Oxidative stress markers in the pregestational period did not have a predictive value in the recurrent pregnancy loss and repeated implantation failure . CCL2 might be useful in risk prediction
Distributions of MCP-1 -2518A/G and VEGF (zeige VEGFA Proteine) -634C/G polymorphisms are significantly different between type 2 diabetes mellitus and diabetic foot ulcer patients
In multivariate analysis, the IL1B (zeige IL1B Proteine) rs16944 TT and TNF (zeige TNF Proteine) rs1799964 TC genotypes were significantly associated with intrauterine cytomegalovirus infection. Twenty-two out of 72 congenitally infected newborns had confirmed sensorineural hearing loss. Carriers of CT or TT genotype of CCL2 rs13900 had increased risk of hearing loss at birth and at 6 months of age.
a novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF.
Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES (zeige CCL5 Proteine) and IGF-1 (zeige IGF1 Proteine) in vitro.
Axotomy Leads to Reduced Calcium Increase and Earlier Termination of CCL2 Release in Spinal Motoneurons.
Our results showed that MIF (zeige MIF Proteine) regulates MCP-1 (zeige CPT1B Proteine) expression in hepatocytes of injured liver via CD74 (zeige CD74 Proteine), CD44 (zeige CD44 Proteine), and p38 MAPK (zeige MAPK14 Proteine) in an autocrine manner.
these studies identify a novel role for the microbiota in shaping immunity, which includes induction of CCL2 levels that control homeostatic trafficking of plasmacytoid dendritic cells
These studies show that elevated levels of CCL2 in the CNS through increased astrocyte expression can significantly interact with the behavioral effects of alcohol.
Topical application of glycolic acid suppresses the UVB induced IL-6 (zeige IL6 Proteine), IL-8 (zeige IL8 Proteine), MCP-1 (zeige CPT1B Proteine) and COX-2 inflammation by modulating NF-kappaB (zeige NFKB1 Proteine) signaling pathway in mouse skin.
Study demonstrated that CD36 (zeige CD36 Proteine) deletion regulated MCP-1 (zeige CPT1B Proteine) expression at the transcriptional level by changing the acetylation of histones binding to the MCP-1 (zeige CPT1B Proteine) promoters in hepatocytes, promoting macrophage migration to the liver, and aggravating hepatic inflammatory response and fibrosis.
Despite higher caloric intake and elevated body weights, carbohydrate restriction lowered serum MCP-1 (zeige CPT1B Proteine) levels, reduced prostate macrophage infiltration, reduced prostate weight, but failed to slow adenocarcinoma development.
Data indicate that ASC (zeige STS Proteine)-J9(R) can suppress CD4 (zeige CD4 Proteine)+ T cell migration via decreasing the cytokine CCL2 in vitro and in vivo.
CXCL10 (zeige CXCL10 Proteine) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.
Porcine CCL2 binding on Tuk4+SLA (zeige SLA Proteine)-II- but not on Tuk4-SLA (zeige SLA Proteine)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment
Contrast media did not affect bone marrow cell viability/MCP-1 secretion.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.
in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta
Variable gene expression (eg, matrix metalloproteinase-9 (zeige MMP9 Proteine), CCL2 and Lp-PLA(2 (zeige Lp-PLA2 Proteine)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (zeige F3 Proteine) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (zeige CRP Proteine)
resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes
Studied SNPs in the bovine toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) and monocyte chemo attractant protein-1(CCL2) genes.
The LEP (zeige LEP Proteine), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum
Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (zeige CXCL12 Proteine) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (zeige IL8 Proteine)) decreased significantly in Dachengqi decoction treatment group.
measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.
Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
C-C motif chemokine 2
, monocyte chemoattractant protein 1
, monocyte chemoattractant protein-1
, monocyte chemotactic and activating factor
, monocyte chemotactic protein 1
, monocyte secretory protein JE
, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
, small inducible cytokine subfamily A (Cys-Cys), member 2
, small-inducible cytokine A2
, platelet-derived growth factor-inducible protein JE
, small inducible cytokine A2
, immediate-early serum-responsive JE protein
, immediate-early serum-responsive protein JE
, small inducible gene JE
, acidic seminal fluid protein
, monocyte chemotactic protein 1A
, chemokine CCL2/MCP-1
, Monocyte chemoattractant protein 1
, Monocyte chemotactic protein 1
, Small-inducible cytokine A2