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Rat (Rattus) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305099
Capsoni, Minonzio, Ongari, Zanussi: A new simplified single-filter assay for 'in vitro' evaluation of chemotaxis of 51Cr-labeled polymorphonuclear leukocytes. in Journal of immunological methods 1989
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305100
Ernst, Zhang, Hancock, Rutledge, Corless, Rollins: Biochemical and biologic characterization of murine monocyte chemoattractant protein-1. Identification of two functional domains. in Journal of immunology (Baltimore, Md. : 1950) 1994
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305101
Rollins, Stier, Ernst, Wong: The human homolog of the JE gene encodes a monocyte secretory protein. in Molecular and cellular biology 1990
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935595
Bogen, Dina, Gear, Levine: Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. in Neuroscience 2009
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Human CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN935639
Frøyland, Pedersen, Kvissel, Almaas, Pharo, Skålhegg, Mollnes, Rootwelt: Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons. in Brain research 2006
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Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413594
Gray, Di Marco, Okabe, Szyndralewiez, Heitz, Montezano, de Haan, Koulis, El-Osta, Andrews, Chin-Dusting, Touyz, Wingler, Cooper, Schmidt, Jandeleit-Dahm: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. in Circulation 2013
Mouse (Murine) CCL2 Protein expressed in Escherichia coli (E. coli) - ABIN413564
Zhu, Daghini, Chade, Rodriguez-Porcel, Napoli, Lerman, Lerman: Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension. in Arteriosclerosis, thrombosis, and vascular biology 2006
CCL2 in addition to IFN-gamma (zeige IFNG Proteine) can be used to differentiate among Mycobacterium tuberculosis infection possibilities.
Results indicated that MCP-1 and CCR2 polymorphisms may influence the progression of IgAN, but not increase/decrease its susceptibility.
Topical application of glycolic acid suppresses the UVB induced IL-6 (zeige IL6 Proteine), IL-8 (zeige IL8 Proteine), MCP-1 and COX-2 inflammation by modulating NF-kappaB (zeige NFKB1 Proteine) signaling pathway in keratinocytes.
Data suggest that, compared to control individuals, patients with T2DM-Y (young onset type 2 diabetes), NPDR (non-proliferative diabetic retinopathy) and PDR (proliferative diabetic retinopathy) exhibit significantly higher serum levels of MCP-1. This study was conducted in India.
The meta-analysis demonstrated that urinary MCP-1 was significantly higher in patients with active LN than in those with inactive LN and control subjects, and the patients with inactive LN showed significantly higher urinary MCP-1 levels than the controls.
investigated whether functional polymorphism at MCP-1 regulatory region associates with disease phenotype in Indian systemic lupus erythematosus patients (SLE) patients; findings suggest that -2518G allele of MCP-1 -2518 A/G polymorphism is associated with renal disorders and may influence MCP-1 gene expression among Indian SLE patients
joint interaction analysis of ACE I/D and CCL2 C-2518T showed a significantly higher frequency of II genotype of ACE I/D in coexistence with TT genotype of CCL2 C-2518T in Henoch-Schonlein purpura (HSP) patients.
EGF (zeige EGF Proteine) up-regulated CCL2 expression in HNSCC cells, which recruited monocytes and turned them into M2-like macrophages, thus forming a positive feedback paracrine loop.
CCL2 gene silencing inhibits primary tumor growth and metastasis, associated with a reduction in cancer stem cell renewal and recruitment of M2 macrophages in triple negative breast cancer
Mesenchymal stem cells from Ankylosing spondylitis patients secreted more monocyte chemoattractant protein 1 (MCP1) during abnormal osteogenic differentiation.
Our results showed that MIF (zeige MIF Proteine) regulates MCP-1 (zeige CPT1B Proteine) expression in hepatocytes of injured liver via CD74 (zeige CD74 Proteine), CD44 (zeige CD44 Proteine), and p38 MAPK (zeige MAPK14 Proteine) in an autocrine manner.
these studies identify a novel role for the microbiota in shaping immunity, which includes induction of CCL2 levels that control homeostatic trafficking of plasmacytoid dendritic cells
These studies show that elevated levels of CCL2 in the CNS through increased astrocyte expression can significantly interact with the behavioral effects of alcohol.
Topical application of glycolic acid suppresses the UVB induced IL-6 (zeige IL6 Proteine), IL-8 (zeige IL8 Proteine), MCP-1 (zeige CPT1B Proteine) and COX-2 inflammation by modulating NF-kappaB (zeige NFKB1 Proteine) signaling pathway in mouse skin.
Study demonstrated that CD36 (zeige CD36 Proteine) deletion regulated MCP-1 (zeige CPT1B Proteine) expression at the transcriptional level by changing the acetylation of histones binding to the MCP-1 (zeige CPT1B Proteine) promoters in hepatocytes, promoting macrophage migration to the liver, and aggravating hepatic inflammatory response and fibrosis.
Despite higher caloric intake and elevated body weights, carbohydrate restriction lowered serum MCP-1 (zeige CPT1B Proteine) levels, reduced prostate macrophage infiltration, reduced prostate weight, but failed to slow adenocarcinoma development.
Data indicate that ASC (zeige STS Proteine)-J9(R) can suppress CD4 (zeige CD4 Proteine)+ T cell migration via decreasing the cytokine CCL2 in vitro and in vivo.
PDAC responds to radiotherapy by producing CCL2, which recruits Ly6C(+)CCR2(+) monocytes to support tumor proliferation and neovascularization after radiotherapy.
Chemokine receptor 2 (CCR2 (zeige CCR2 Proteine)(+)) monocytes invade the hippocampus between 1 and 3 d after SE. In contrast, only an occasional CD3 (zeige CD3E Proteine)(+) T lymphocyte was encountered 3 d after SE. The initial cellular sources of the chemokine (zeige CCL1 Proteine) CCL2, a ligand for CCR2 (zeige CCR2 Proteine), included perivascular macrophages and microglia. The induction of the proinflammatory cytokine IL-1beta (zeige IL1B Proteine) was greater in FACS-isolated microglia than in brain-invading monocytes
data suggest that MCP-1 (zeige CPT1B Proteine) may be a necessary component of the inflammatory response required for adipose tissue protection, remodeling and healthy expansion in the FVB/N strain in response to high-fat diet feedings
resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes
Studied SNPs in the bovine toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) and monocyte chemo attractant protein-1(CCL2) genes.
The LEP (zeige LEP Proteine), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum
ghrelin (zeige GHRL Proteine) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF (zeige VEGFA Proteine) and VEGFR2 (zeige KDR Proteine) expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits
Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (zeige CXCL12 Proteine) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.
In a cerebral aneurysm, expression of MCP1 peaked after induction for one week, then decreased. MCP1 induced macrophage adhesion and infiltration in the artery wall of aneurysms, and contributed to the occurrence and development of brain aneurysm.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (zeige IL8 Proteine)) decreased significantly in Dachengqi decoction treatment group.
measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.
Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.
CXCL10 (zeige CXCL10 Proteine) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.
Porcine CCL2 binding on Tuk4+SLA (zeige SLA Proteine)-II- but not on Tuk4-SLA (zeige SLA Proteine)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment
Contrast media did not affect bone marrow cell viability/MCP-1 secretion.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.
in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta
Variable gene expression (eg, matrix metalloproteinase-9 (zeige MMP9 Proteine), CCL2 and Lp-PLA(2 (zeige Lp-PLA2 Proteine)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (zeige F3 Proteine) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (zeige CRP Proteine)
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
small inducible cytokine A2
, C-C motif chemokine 2
, immediate-early serum-responsive JE protein
, immediate-early serum-responsive protein JE
, monocyte chemoattractant protein 1
, monocyte chemoattractant protein-1
, monocyte chemotactic protein 1
, small inducible gene JE
, small-inducible cytokine A2
, monocyte chemotactic and activating factor
, monocyte secretory protein JE
, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
, small inducible cytokine subfamily A (Cys-Cys), member 2
, platelet-derived growth factor-inducible protein JE
, acidic seminal fluid protein
, monocyte chemotactic protein 1A
, chemokine CCL2/MCP-1
, antiadrenocorticotropin peptide III
, corticostatin III
, macrophage antibiotic peptide MCP-1
, mast cell protease 1A