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Overexpression of mitochondrial Trx2 attenuates the intracellular ROS (zeige ROS1 Proteine) accumulation and ATP production. Most interestingly, mitochondrial Trx2 may be involved in the cardiac hypertrophy signaling of diabetes.
Prx3 (zeige PRDX3 Proteine) and Trx2 comprise an adaptive system to sense changes in atmospheric oxygen tension and influence cellular injury responses through both detoxification of mitochondrial oxidants and regulation of mitochondrial redox-dependent signaling
Trx2 overexpression failed to attenuate hypoxia-induced human pulmonary arterial smooth muscle cells proliferation in vitro or hypoxia-induced Pulmonary hypertension in vivo.
study demonstrated that miR (zeige MLXIP Proteine)-27a and -b, which are widely expressed in host cells, suppress SNAP25 (zeige SNAP25 Proteine) and TXN2 expression through posttranscriptional gene silencing.
No evidence that SNPs in TRX2 have effects, but the rs4485648 polymorphism of the TrxR2 (zeige TXNRD2 Proteine) gene might exert an independent effect on the development of Diabetic retinopathy.
Thioredoxin 2 Is a Novel E2-Interacting Protein That Inhibits the Replication of Classical Swine Fever Virus by promoting the nuclear translocation of the p65 (zeige GORASP1 Proteine) subunit of NF-kappaB (zeige NFKB1 Proteine).
The Grx2 (zeige GRX2 Proteine) system could help to keep Trx2/1 reduced during an oxidative stress, thereby contributing to the anti-apoptotic signaling.
CERKL (zeige CERKL Proteine) interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway.
TGF-beta (zeige TGFB1 Proteine)-mediated expression of the epithelial-mesenchymal transition marker fibronectin (zeige FN1 Proteine) was inhibited not only by chemicals that interfere with reactive oxygen species signaling but also by exogenously expressed mitochondrial thioredoxin.
We showed that overexpression of TRXs reduced cell death; TRX2 was expressed in the mitochondria, while TRX1 (zeige MLL Proteine) was expressed in the cytoplasm.
This is the first demonstration of biochemical and physiological consequences caused by loss of Trx-2 in Drosophila.
gene for thioredoxin (DmTrx-2) was cloned and expressed, and the protein characterized
Drosophila thioredoxin can function as an anti-aging agent and as a suppressor of Parkin-associated endothelin receptor-like receptor - and poly-glutamine-induced neurotoxicity
Trx-2 affects lifespan in Drosophila. Mutants have a decreased lifespan.
The ventral signal observed from early stages colocalized with motor neuron markers Isl1 (zeige ISL1 Proteine)/2 and FoxP1 (zeige FOXP1 Proteine) and the strong ventral signal colocalizing with Isl1 (zeige ISL1 Proteine)/2 was observed in all rostrocaudal segments of the spinal cord.
TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity
An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species.
The SirT1 (zeige SIRT1 Proteine) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (zeige SOD2 Proteine), catalase (zeige CAT Proteine), peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2 (zeige TXNRD2 Proteine), and uncoupling protein 2 (zeige UCP2 Proteine).
This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression.
Both thioredoxin 2 and glutaredoxin 2 (zeige GRX2 Proteine) contribute to the reduction of the mitochondrial 2-Cys (zeige DNAJC5 Proteine) peroxiredoxin Prx3 (zeige PRDX3 Proteine).
Data show that Nrf2 (zeige NFE2L2 Proteine) activity was increased in WT MEFs at the 0 or -46 mV conditions, but was inhibited in Trx2 Tg MEFs under the same conditions.
the rapid E2-mediated activation of the Txn (zeige TXN Proteine) pathway is an important step in the response of the mammalian uterus to estrogen.
Trx2 is an endogenous regulator of the mitochondrial permeability transition.
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
, thioredoxin, mitochondrial
, thioredoxin 2
, Thioredoxin 2
, thioredoxin nuclear gene encoding mitochondrial protein