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anti-Human HAP1 Antikörper:
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Human Monoclonal HAP1 Primary Antibody für ICC, FACS - ABIN259097
Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. in Human molecular genetics 2002
Show all 7 Pubmed References
Human Polyclonal HAP1 Primary Antibody für IHC, ELISA - ABIN1002402
Borrell-Pagès, Zala, Humbert, Saudou: Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. in Cellular and molecular life sciences : CMLS 2006
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Monoclonal HAP1 Primary Antibody für IHC (fro), IP - ABIN534035
Gutekunst, Torre, Sheng, Yi, Coleman, Riedel, Bujo: Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003
Show all 2 Pubmed References
Human Polyclonal HAP1 Primary Antibody für ELISA, WB - ABIN188689
Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. in Human molecular genetics 2006
HAP1 (zeige APEX1 Antikörper) is expressed in endocrine cells of the human gut (zeige GUSB Antikörper).
data fully support that HAP1 (zeige APEX1 Antikörper) is a GKAP (zeige DLGAP1 Antikörper), anchoring specifically to the cGMP-dependent protein kinase (zeige CDK7 Antikörper) isoform Ibeta, and provide further evidence that also PKG (zeige PRKG1 Antikörper) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (zeige APEX1 Antikörper) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (zeige APEX1 Antikörper) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (zeige APEX1 Antikörper) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (zeige APEX1 Antikörper) co-localizes and associates with APP (zeige APP Antikörper) in physiological conditions of mouse and human brain.
WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1).
HAP1 (zeige APEX1 Antikörper)/stigmoid body interacts with the normal ataxin-3 (zeige ATXN3 Antikörper) through Josephin (zeige ATXN3 Antikörper) domain
sortilin (zeige SORT1 Antikörper) stabilizes the proBDNF.HAP1 complex
ADORA2A (zeige ADORA2A Antikörper), but not HAP1 (zeige APEX1 Antikörper) or OGG1 (zeige OGG1 Antikörper), may have a role in age at onset in Huntington's disease
Depleting Huntingtin-associated protein 1 (Hap1) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A (zeige DYRK1A Antikörper))-DDB1 and CUL4 associated factor 7 (Dcaf7 (zeige DCAF7 Antikörper)) interaction and increased the DYRK1A (zeige DYRK1A Antikörper) protein level.
This study also validated the interaction between HAP1 and Sec23A (zeige SEC23A Antikörper) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins
HAP1 co-localizes with synapsin I (zeige SYN1 Antikörper) in cortical neurons as discrete puncta
findings suggest that Hap1 is important for insulin (zeige INS Antikörper) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (zeige CACNA1C Antikörper), providing new insight into the mechanisms that regulate insulin (zeige INS Antikörper) release from pancreatic beta-cells.
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (zeige BCR Antikörper) on microtubules to regulate neuronal differentiation.
HAP1 regulates exocytosis by influencing the morphological docking of vesicles at the plasma membrane, the ability of vesicles to be released rapidly upon stimulation, and the early stages of fusion pore formation.
these studies identify htt (zeige HTT Antikörper) and HAP1 as regulators of autophagosome transport in neurons
In the absence of HAP1, postnatal hypothalamic neurons exhibited reduced receptor tropomyosin-related kinase B (TRKB (zeige NTRK2 Antikörper)) levels.
Hap1-Tsc1 (zeige TSC1 Antikörper) interaction regulates neuronal mTORC1 signaling and neuronal morphogenesis.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)