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Nectin-3 mutation in men with severe teratospermia
Data suggest that 3 independent regions of TcdB (Clostridium difficile toxin B; 1372-1493, 1493-1848, 1851-2366) contribute to binding and entry of TcdB into mammalian cells; residues 1372-1493 are sufficient for interaction with PVRL3.
Expression of nectin-3 in pancreatic cancer can be a prognostic factor.
PVRL3 is a physiologically relevant binding partner that can serve as a target for the prevention of TcdB-induced cytotoxicity in C. difficile infection.
Nectin-3 is associated with the formation of cell junctions and be a putative suppressor molecule to the invasion of breast cancer cells.
Nectin-3 trans-interacts with Nectin-2 (zeige PVRL2 Proteine) to promote lymphocyte and monocyte extravasation.
Data suggest that expression of nectin-3 is up-regulated in eutopic endometrium of patients with endometriosis as compared with control subjects and up-regulated in all endometriotic lesions investigated compared with eutopic endometrium.
Nectin-3 expressed in dentate gyrus neurons may modulate adult neurogenesis, dendritic spine plasticity and the cognitive effects of early-life stress.
-afadin-specific C-terminal inserts may be involved in its preference of binding to nectin-3 and raise the possibility that there are proteins other than nectins that more preferentially bind s-afadin than l-afadin.
owing to the loss of Nectin-3, hair cells contact each other inappropriately and form abnormal junctions, ultimately resulting in abnormal hair bundle orientation and morphology
Results indicate that PLEKHA7 plays a cooperative role with nectin and afadin in the proper formation of Adherens junction (AJ) in epithelial cell.
This study demonstrated that nectin1- and nectin3-mediated interactions between Cajal-Retzius cells cells and migrating neurons are critical for radial migration.
Cell adhesion molecule (zeige MCAM Proteine) nectin-3 is required for the effects of corticotropin releasing hormone (zeige CRH Proteine) receptor (zeige NR4A1 Proteine) (CRHR)1 (zeige CRHR1 Proteine) on cognition and structural remodeling after early-life stress exposure.
Nectin-3, which forms hetero-trans-dimers with nectin-1 (zeige PVRL1 Proteine), undergoes intramembrane cleavage mediated by PS1 (zeige PSEN1 Proteine)/gamma-secretase.
hair cells and supporting cells express nectin-1 (zeige PVRL1 Proteine) and -3, respectively; their interaction mediates the heterotypic adhesion between these 2 cell types; nectin-1 (zeige PVRL1 Proteine) and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia
Results suggest that heterophilic interaction between nectin-1 (zeige PVRL1 Proteine) and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation.
nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants.
poliovirus receptor-related 3
, poliovirus receptor-related protein 3-like
, nectin 3
, poliovirus receptor-related protein 3