PTPRK Proteine (PTPRK)

Bezeichnung:: Protein Tyrosine Phosphatase Receptor Type K Proteine (PTPRK)

Auf www.antikoerper-online.de finden Sie aktuell 8 Protein Tyrosine Phosphatase Receptor Type K (PTPRK) Proteine von 0 unterschiedlichen Herstellern. Insgesamt sind aktuell 30 PTPRK Produkte verfügbar.

Synonyme:: AI853699, PTPk, R-PTP-kappa, Rptpk, RPTPkappa

alle Proteine anzeigen	Gen	GeneID	UniProt
Human PTPRK	PTPRK	5796	Q15262
Ratte PTPRK	PTPRK	360302
Maus PTPRK	PTPRK	19272	P35822
Weitere Synonyme anzeigen

Verknüpfte Pathways mit PTPRK Proteine

Cell-Cell Junction Organization

Weitere Produktkategorien zu PTPRK Protein

Weitere Proteine zu PTPRK Interaktionspartnern

Human Protein Tyrosine Phosphatase Receptor Type K (PTPRK) Interaktionspartner

Study found a significant association between PTPRK genetic variants and the risk and age at onset of Alzheimer's disease in two independent samples, and provided initial evidence of several genetic variants in PTPRK influencing the risk of cancer and cholesterol levels.
The present study identified RSPO (zeige RSPO1 Proteine) fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA (zeige PRDX2 Proteine)) and showed that PTPRK-RSPO3 (zeige RSPO3 Proteine) fusions were the predominant cause of RSPO (zeige RSPO1 Proteine) overexpression in colorectal TSA (zeige PRDX2 Proteine).
PTPRK plays dual roles in coordinating angiogenesis. It plays a positive role in cell proliferation, adhesion and tubule formation, but suppresses cell migration, in particular, the FGF-promoted migration.
PTPRK-RSPO3 (zeige RSPO3 Proteine) fusions and RNF43 (zeige RNF43 Proteine) mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).
By regulating phosphorylation of SRC, RPTPkappa promotes the pathogenic action of rheumatoid arthritis fibroblast-like synoviocytes, mediating cross-activation of growth factor and inflammatory cytokine signalling by TGFbeta in RA FLS.
Notch (zeige NOTCH1 Proteine) and TGF-beta (zeige TGFB1 Proteine) act in concert to stimulate induction of PTPRK, which suppresses EGFR (zeige EGFR Proteine) activation in human keratinocytes.
Findings strongly indicate that the tyrosine phosphorylation of CD133, which is dephosphorylated by PTPRK, regulates AKT (zeige AKT1 Proteine) signaling and has a critical role in colon cancer progression.
PTPRK underexpression leads to STAT3 (zeige STAT3 Proteine) activation and contributes to nasal NK/T-cell lymphoma pathogenesis
PTPRK showed lower mRNA expression in duodenal mucose of celiac disease patients.
High expression of PTPRK is associated with prostate cancer.

Mouse (Murine) Protein Tyrosine Phosphatase Receptor Type K (PTPRK) Interaktionspartner

RPTP-kappa is proteolytically processed to isoforms that have opposing effects on beta-catenin (zeige CTNNB1 Proteine) activity.

PTPRK Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.

Alternative names and synonyms associated with PTPRK

protein tyrosine phosphatase, receptor type K (PTPRK)
protein tyrosine phosphatase, receptor type, K (Ptprk)
protein tyrosine phosphatase, receptor type K (Ptprk)

AI853699 Protein
PTPk Protein
R-PTP-kappa Protein
Rptpk Protein
RPTPkappa Protein

Bezeichner auf Proteinebene für PTPRK

dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa , protein-tyrosine phosphatase kappa , protein-tyrosine phosphatase, receptor type, kappa , receptor-type tyrosine-protein phosphatase kappa , protein tyrosine phosphatase, receptor type, K, extracellular region , receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK) , R-PTP-kappa

GENE ID	SPEZIES
5796	Homo sapiens
360302	Rattus norvegicus
19272	Mus musculus
100339990	Oryctolagus cuniculus
100730543	Cavia porcellus
100153609	Sus scrofa
476290	Canis lupus familiaris
509657	Bos taurus
421711	Gallus gallus
101116916	Ovis aries

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