anti-F2RL2 (F2RL2) Antikörper

Bezeichnung:: anti-Coagulation Factor II (thrombin) Receptor-Like 2 Antikörper (F2RL2)

Auf www.antikoerper-online.de finden Sie aktuell 139 Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) Antikörper von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen F2RL2 Kits (20) und F2RL2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 166 F2RL2 Produkte verfügbar.

Synonyme:: f2rl2, F730031A08, PAR-3, par3

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	F2RL2	2151	O00254
	F2RL2	14064	O08675
	F2RL2	29636	Q920E1
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human F2RL2 Antikörper:

anti-Mouse (Murine) F2RL2 Antikörper:

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Human Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) Interaktionspartner

PAR3 is essential in thrombin (zeige F2 Antikörper) stimulated insulin (zeige INS Antikörper) secretion.
TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (zeige NOS3 Antikörper)-Thr (zeige TRH Antikörper)-495 with minimal phosphorylation of eNOS (zeige NOS3 Antikörper)-Ser (zeige SIGLEC1 Antikörper)-1177 with no change in nitric oxide production.
These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR (zeige JTB Antikörper) activation, such as the activation of vascular-protective Tie2 (zeige TEK Antikörper) by noncanonical PAR3 activation.
In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin (zeige CDH1 Antikörper), leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav.
Data indicate that knockdowns of all three PARs (zeige EPRS Antikörper) PAR-1 (zeige MARK2 Antikörper), PAR-2 (zeige F2RL1 Antikörper), and PAR-3 exhibited changes in the expression of CDC42 (zeige CDC42 Antikörper), which correlated with the changes in their invasion.
Elevated expression of PAR-3, b (zeige MARK2 Antikörper)ut not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients.
A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C cytoprotective effects.
PAR-3 receptors interact with thrombin (zeige F2 Antikörper) and increase heme oxygenase-1 (zeige HMOX1 Antikörper) expression in synovial fibroblasts.
Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR (zeige ELAVL1 Antikörper), whereas transcriptional control involves nuclear factor of activated T cells (NFAT (zeige NFATC1 Antikörper)).
FXa (zeige F10 Antikörper) bound in a punctate manner to thrombi under shear, while thrombin (zeige F2 Antikörper) and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) Interaktionspartner

Data show that activated protein C (zeige PROC Antikörper) signals via protease activated receptors PAR2 (zeige F2RL1 Antikörper)/PAR3 to expand Treg cells, mitigating the disease in mice.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2 (zeige IQGAP2 Antikörper)) and F2rl2
Simultaneous depletion of PAR-1 (zeige MARK2 Antikörper) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
these data point to a novel kallikrein 6 (zeige KLK1 Antikörper) -signaling axis in neurons that is mediated by PAR1 (zeige F2R Antikörper) and PAR2 (zeige F2RL1 Antikörper) and is positioned to contribute to neurodegeneration
Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (zeige F3 Antikörper)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)
PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (zeige F2R Antikörper)-type thrombin (zeige F2 Antikörper) receptors
Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (zeige F2RL3 Antikörper) by the active site of thrombin (zeige F2 Antikörper).

F2RL2 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.

Alternative names and synonyms associated with F2RL2

coagulation factor II thrombin receptor like 2 (F2RL2) Antikörper
coagulation factor II (thrombin) receptor-like 2 (f2rl2) Antikörper
coagulation factor II (thrombin) receptor-like 2 (F2rl2) Antikörper
coagulation factor II (thrombin) receptor-like 2 L homeolog (f2rl2.L) Antikörper

f2rl2 Antikörper
F730031A08 Antikörper
PAR-3 Antikörper
par3 Antikörper

Bezeichner auf Proteinebene für F2RL2

Coagulation factor II receptor-like 2 (protease-actovated receptor 3) , protease-activated receptor 3 , proteinase-activated receptor 3 , proteinase-activated receptor-3 , thrombin receptor-like 2 , PAR-3 , Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2) , coagulation factor II receptor-like 2 , coagulation factor II (thrombin) receptor-like 2 L homeolog

GENE ID	SPEZIES
2151	Homo sapiens
100148468	Danio rerio
14064	Mus musculus
29636	Rattus norvegicus
512581	Bos taurus
379226	Xenopus laevis

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